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CELL PROLIFERRATION AND PROGRAMED CELL DEATH FOR MORPHOMETRIC POSITIONING OF STRUCTURAL PATTERN AND DEVELOPMENTAL GROWTH DERECTION IN EPITHELIAL-MESENCHYMAL MORPHOGENESIS.

细胞增殖和程序性细胞死亡用于结构模式的形态定位和上皮间质形态发生中的发育生长方向。

基本信息

批准号：
09660330
负责人：
AMASAKI Hajime
金额：
$ 2.18万
依托单位：
NIPPON VETERINARY AND ANIMAL SCIENCE UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09660330/
关键词：
Organogenesis Interaction Proliferation Apoptosis Arrangement Positioning

项目摘要

Present research was produced to reveal the mechamism of regularly patterned structure of the organ and the topological consorted growing orientations with organic specific differentiations in the epithelial-mesenchymal composed organ. We used the developmental murian and cow's palatine ridge systems and also the developmental cow's ruminal papillary system for an investigation of structural patterns of analysis, and the murian intestinal system for the functional diffrentiation of analysis under the cell cycle controls. While, control mechanisms of some specific gene expresssions and the cell cycle systems for the morphogenesis in above digestive organs were recomfirmed to be affected with the consorted expressions of many extra-cellular matrices, those of cell adhesion mollecules, those of integlins at the interface between the epithelial cell and the subepithelial mesenchyme, and also those of intracelluar micro-fibriles (J. Vet. Med. Sci., 1997, 1999). The cell cycle was known to be controled by the cell proliferation and the programed cell death. Present developmental systems in vivo strongly suggested to the primary intiations of structural position and growing orientations with specific functional diffrentiations would be also affected with the cell cycle systems (Immunology, 1999, in preparation for submission). Additionaly, methods for the organ-culture system of present research and for the detection with some mRNAs in cell system and cell differentiations would be masterd under present accumplised research.

本研究旨在揭示由上皮-间充质组成的器官的规则结构以及与器官特异性分化相关的拓扑生长方向的机制。我们用发育中的鼠和牛的腭嵴系统以及发育中的牛的瘤胃乳头系统进行结构模式分析的研究，并用鼠的肠系统进行细胞周期控制下的功能分化分析。同时，上述消化器官中某些特定基因表达和细胞周期系统的控制机制被证实受到许多细胞外基质，细胞粘附分子，上皮细胞和上皮下间质界面处的整合素以及细胞内微纤维的联合表达的影响（J. Vet. Med. Sci.，1997年、1999年）。细胞周期受细胞增殖和细胞程序性死亡的控制。目前的体内发育系统强烈表明，具有特定功能分化的结构位置和生长方向的初级起始也会受到细胞周期系统的影响（Immunology，1999，准备提交）。另外，本研究的器官培养系统以及细胞系统和细胞分化过程中某些mRNA的检测方法也将在目前的研究中掌握。