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Habit Control of Aspartic Acid Crystal by Using Trace Amount of Additives

使用微量添加剂控制天冬氨酸晶体的习性

基本信息

批准号：
09650839
负责人：
KUBOTA Noriaki
金额：
$ 2.3万
依托单位：
Iwate University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09650839/
关键词：
Aspartic acid Amino acid crystal growth rate additive impurity crystal habit crystal shape L-glutamine L-グルタミン L-アスパラギン結晶 L-グルタミン酸 L-アスパラギン酸

项目摘要

L-glutamine, L-glutamic acid and L-aspragine were selected as effective additives. The growth rate of an asparitic acid crystal was measured in the presence of each additive. The growth rate in the direction of c-axis of the crystal was suppressed by any of these additives. The growth suppression effect of these additives was different and it was in the order of L-glutamine, L-glutamic acid and L-asparagine. The former two showed nearly the same effect, but the effectiveness of L-asparagine was half that of the former twos. These data were analyzed by a theory previously proposed by the authors. In the theory, the propagation of the steps and crystal growth rate is considered to be suppressed by additive species adsorbed on the crystal surface on the step lines at kink sites. The difference in the effectiveness among the three additives are concluded to depend on the length between the active sites on which additive species are adsorbed. Further, the difference in the length is estimated to be caused by the difference between the chemical structures of L-asparrtic acid (crystallizing species) and an additive. Thus, the chemical structure was related to the kinetics of crystal growth.As mentioned above, the growth rate of an aspartic acid crystal was shown to be suppressed in the direction of c-axis in the presence of any of L-glutamine, L-glutamic acid and L-asparagine. In this study, the growth rates of other crystals (potassium sulfate and potassium alum crystals) were also measured in the presence of impurities and analyzed. The additives examined were effective. The habit of these crystals can be controlled by these additives. Experiments on habit control was made on potassium alum crystals by using Bismarck Brown G as an additive. The habit was controlled successfully. Experiments on habit control are still in progress.

筛选出L-谷氨酰胺、L-谷氨酸和L-天冬氨酸为有效添加剂。在每种添加剂的存在下测量异辛酸晶体的生长速率。在晶体的c轴方向上的生长速率被抑制由这些添加剂中的任何一个。不同添加剂对生长的抑制作用不同，其抑制效果依次为L-谷氨酰胺、L-谷氨酸和L-天冬酰胺。前两者的效果几乎相同，但L-天冬酰胺的效果是前两者的一半。这些数据由作者先前提出的理论进行了分析。在理论中，台阶的传播和晶体生长速率被认为是抑制的添加剂物种吸附在晶体表面上的阶跃线在扭折网站。三种添加剂之间的有效性的差异的结论取决于添加剂物种被吸附的活性位点之间的长度。此外，估计长度的差异是由L-酒石酸（结晶物质）和添加剂的化学结构之间的差异引起的。如上所述，在L-谷氨酰胺、L-谷氨酸和L-天冬酰胺中的任一种存在下，天冬氨酸晶体的生长速率在c轴方向上被抑制。在这项研究中，其他晶体（硫酸钾和钾明矾晶体）的生长速率也在杂质的存在下进行了测量和分析。所检查的添加剂是有效的。这些晶体的习性可以通过这些添加剂来控制。以俾斯麦棕G为添加剂，对钾明矾晶体进行了习性控制试验。这个习惯被成功地控制住了。控制习惯的实验仍在进行中。