Development of ultra-fast funcional MRI

血氧水平依赖(BOLD)对比功能磁共振成像(MRI)使人类高级脑功能的研究发生了革命性变化。尽管如此，该方法仍然存在着各种缺陷。与普遍认为的相反，目前形式的BOLD-fMRI在时间分辨率方面没有足够的有效性。这些项目旨在利用高场(3.OT)系统进一步完善BOLD-fMRI技术，特别是在时间分辨率方面。该项目的技术成果包括(1)BOLD-fMRI水平3.0T系统的优化，(2)垂直3.0T系统开发所需的各种关键技术的实现，(3)fMRI和高密度(256通道)脑电地形图的同步分析。该项目还产生了各种神经科学发现，包括发现了运动前无运动区，人类右脑在三维视觉信息处理中占据主导地位，以及精神分裂症患者在工作记忆任务中缺乏适当的背外侧额叶激活。

Blood oxygenation level dependent (BOLD) contrast functional magnetic resonance imaging (MRI) has revolutionized the investigations of higher brain function in humans. Nevertheless, the method still has various shortcomings. Contrary to popular belief, BOLD-fMRI in the current form does not possess sufficient validity regarding temporal resolution. The projects are designed to further refine the BOLD-fMRI technique utilizing a high-field (3.OT) system, especially in the aspect of temporal resolution. Technical achievements of the project include (1) optimization of horizontal 3.0T system for BOLD-fMRI, (2) realization of various critical technologies necessary in the development of a vertical 3.0T system, and (3) synchronized analysis of fMRI and high-density (256 channel) EEG topography. The project has also yielded various neuroscientific findings, including the discovery of a premotor no-motion area, right hemisphere dominance in 3 dimensional visual information processing in humans, and lack of appropriate dorsolateral frontal lobe activation in schizophrenic patients during a working memory task.