Novel chimeric antigen receptor modified T cells against IGF receptor for osteosarcoma

针对骨肉瘤 IGF 受体的新型嵌合抗原受体修饰 T 细胞

• 批准号: 15K09648
• 负责人: NIshio Nobuhiro
• 金额: $ 3.08万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K09648/
• 关键词: キメラ抗原受容体; 骨肉腫

项目成果

Enhanced Expression of Anti-CD19 Chimeric Antigen Receptor in piggyBac Transposon-Engineered T Cells.

• DOI: 10.1016/j.omtm.2017.12.003
• 发表时间: 2018-03-16
• 期刊: Molecular therapy. Methods & clinical development
• 作者: Morita D;Nishio N;Saito S;Tanaka M;Kawashima N;Okuno Y;Suzuki S;Matsuda K;Maeda Y;Wilson MH;Dotti G;Rooney CM;Takahashi Y;Nakazawa Y
• 通讯作者: Nakazawa Y

PiggyBac mediated CD19 chimeric antigen receptor modified T cells for a first in human clinical trial.

PiggyBac 介导的 CD19 嵌合抗原受体修饰 T 细胞首次进行人体临床试验。

• 发表时间: 2016
• 作者: Nobuhiro Nishio;Yozo Nakazawa;Motoharu Hamada;Satoshi Suzuki;Miyuki Takana;Daisuke Morita;Nozomu Kawashima;Yusuke Okuno;Atsushi Narita;Asahito Hama;Hideki Muramatsu;Wilson H. Matthew;Cliona M. Rooney;Gianpietro Dotti;Seiji Kojima;Yoshiyuki
• 通讯作者: Yoshiyuki

Durable Remission After Salvage Chemotherapy with Combining Bortezomib and Vorinostat Followed by CD19 CAR-T Therapy in a Patient with MLL-rearranged ALL After Early Relapse Post Allogeneic Hematopoietic Stem Cell Transplantation

MLL 重排 ALL 患者在同种异体造血干细胞移植后早期复发后，采用硼替佐米和伏立诺他联合挽救化疗，随后进行 CD19 CAR-T 治疗，获得持久缓解

• 发表时间: 2017
• 作者: Nobuhiro Nishio;Kai Wang;Shinsuke Kataoka;Kotaro Narita;Hironobu Kitazawa;et al.
• 通讯作者: et al.

PiggyBac mediated T cells expressing CD19 chimeric antigen receptor for a “first in human” clinical trial

PiggyBac 介导的 T 细胞表达 CD19 嵌合抗原受体，用于“人类首次”临床试验

• 发表时间: 2016
• 作者: Nobuhiro Nishio;Yozo Nakazawa;Motoharu Hamada;Satoshi Suzuki;Miyuki Takana;Daisuke Morita;Nozomu Kawashima;Yusuke Okuno;Atsushi Narita;Asahito Hama;Hideki Muramatsu;Wilson H. Matthew;Cliona M. Rooney;Gianpietro Dotti;Seiji Kojima;Yoshiyuki
• 通讯作者: Yoshiyuki

CAR-T cell in Leukemia

CAR-T细胞治疗白血病

• 发表时间: 2017
• 作者: Morita Daisuke;Nishio Nobuhiro;Saito Shoji;Tanaka Miyuki;Kawashima Nozomu;Okuno Yusuke;Suzuki Satoshi;Matsuda Kazuyuki;Maeda Yasuhiro;Wilson Matthew H.;Dotti Gianpietro;Rooney Cliona M.;Takahashi Yoshiyuki;Nakazawa Yozo;小野真太郎,金兼弘和,柳町昌克,岡野翼,星野顕宏,高木正稔,今井耕輔,森尾友宏;石川貴充;今井耕輔,寺田尚美,森尾友宏;Nobuhiro Nishio
• 通讯作者: Nobuhiro Nishio