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The evolution of resistance and virulence in structured populations

结构化人群中耐药性和毒力的演变

基本信息

批准号：
86730235
负责人：
Professorin Dr. Susanne Foitzik
金额：
--
依托单位：
Arbeitsgruppe Foitzik - Verhaltensökologie und Soziale Evolution
依托单位国家：
德国
项目类别：
Research Units
财政年份：
2008
资助国家：
德国
起止时间：
2007-12-31 至 2015-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/86730235?language=en
关键词：
evolution resistance virulence structured populations

项目摘要

Geographic patterns of resistance and virulence depend on the fitness consequences of these traits and the population structure. Socially parasitic slavemaking ants use allospecific workers – stolen during raids – to raise their young. Hosts developed defenses to evade parasitism – e.g. a newly found inducible defense – or to mitigate its costs after enslavement like the “slave rebellion” trait: enslaved Temnothorax workers were observed to kill pupae of the slavemaking ant Protomognathus americanus. The ensuing reduced growth of parasite nests leads to fewer and less destructive raids. We analyzed whether brood destruction raises the inclusive fitness of enslaved workers by reducing the raiding risk for related host colonies nearby. Genetic analyses detected weak host structure and host colonies that survived raids, which could directly benefit from rebellion of their slave relatives. A simulation showed that host structure and the costs of defense influence whether the slave rebellion trait can spread. Costs could include the erroneous killing of own brood and killing rates of parasite and host populations co-varied geographically. We now plan to explore how local structure and the costs / benefits of defenses explain the inter- and intra-population variation in trait expression for various defense traits. With theoretical models we will analyze how metapopulation structure affects the chances of defense or virulence alleles to persist in a population. We will develop computational methods to estimate parameters of host-parasite interactions in a metapopulation context.

抗性和毒力的地理格局取决于这些性状和种群结构的适应性后果。社会寄生的奴隶制造蚂蚁使用异源工人-在袭击中被偷走-来抚养他们的孩子。牠们发展出防御系统以逃避寄生-例如一种新发现的诱导型防御-或在被奴役后减少其成本，如“奴隶叛乱”的特征：被奴役的Temnothorax工人被观察到杀死奴隶制蚂蚁Protomognathus americanus的幼虫。随之而来的寄生虫巢穴的增长减少导致破坏性的袭击越来越少。我们分析了是否育雏破坏提高了包容性健身奴役工人减少袭击风险附近的相关主机殖民地。遗传分析发现了薄弱的主机结构和主机殖民地幸存下来的袭击，这可能直接受益于他们的奴隶亲属的叛乱。模拟结果表明，宿主结构和防御成本影响奴隶反叛性状能否传播。成本可能包括错误杀死自己的育雏和杀死率的寄生虫和宿主人口共同变化的地理。我们现在计划探索如何本地结构和防御的成本/效益解释不同防御性状的性状表达的种群间和种群内变异。通过理论模型，我们将分析集合种群结构如何影响防御或毒力等位基因在种群中持续存在的机会。我们将开发计算方法来估计集合种群背景下宿主与寄生虫相互作用的参数。