The role of hyaluronan in antigen and immune cell trafficking

透明质酸在抗原和免疫细胞运输中的作用

• 批准号: LP200201042
• 负责人: Prof Chris Porter
• 金额: $ 38.51万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP200201042
• 关键词: role; hyaluronan; antigen; immune; cell

This project aims to examine how hyaluronidase, an enzyme that breaks down hyaluronan (a structural component of the skin), affects antigen and cell trafficking to lymph nodes. The project expects to generate new knowledge on the role of hyaluronan in antigen presentation and immunity and to build an interdisciplinary collaboration across immunology, lymphatic transport and material science. The expected outcomes of the project are the development of new knowledge and new models to explore immunity, interdisciplinary training for researchers and post graduate students and a roadmap of the importance of hyaluronan in antigen trafficking.

该项目旨在研究透明质酸酶(一种分解透明质酸(皮肤的结构成分)的酶)如何影响抗原和细胞向淋巴结的运输。该项目希望就透明质酸在抗原呈递和免疫中的作用产生新的知识，并在免疫学、淋巴运输和材料科学之间建立跨学科的合作。该项目的预期成果是开发探索免疫的新知识和新模型，对研究人员和研究生进行跨学科培训，以及制定透明质酸在抗原贩运中的重要性的路线图。