A structure-based design approach to maximising targeting interactions

基于结构的设计方法可最大化目标交互

• 批准号: LP200100540
• 负责人: Prof Chris Porter
• 金额: $ 30.19万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-07-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP200100540
• 关键词: structure; based; design; approach; maximising

This project aims to build on a highly successful collaboration between the Australian biotechnology company Starpharma and Monash University, to better understand the design of next generation nanomaterials that home to specific target cells. The project seeks to capitalize on recent advances in dendrimer chemistry and protein engineering to explore the design of nanomaterials linked to engineered antibody fragments. The anticipated goal is attainment of exquisite, cell specific targeting affinity. Targeted nanomaterials have the potential to transform the clarity of imaging technologies; to facilitate the design of sensors and diagnostics that detect biochemical change in highly select cell populations and to revolutionise drug delivery.

该项目旨在建立在澳大利亚生物技术公司StarPharma和莫纳什大学之间非常成功的合作基础上，以更好地了解特定靶细胞所在的下一代纳米材料的设计。该项目寻求利用树枝状大分子化学和蛋白质工程方面的最新进展，探索与工程抗体片段相关的纳米材料的设计。预期的目标是获得精致的、细胞特异性的靶向亲和力。靶向纳米材料有可能改变成像技术的清晰度；促进传感器和诊断的设计，以检测高度精选的细胞群体中的生化变化，并彻底改变药物输送。