Fundamental Study for the Non-Invasive Laser Coagulation Method

无创激光凝固法的基础研究

• 批准号: 09555070
• 负责人: SHOJI Masahiro
• 金额: $ 8.06万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09555070/
• 关键词: Surgery using Laser; Non-invasive surgery; Surface cooling; Laser coagulation; Laser heating; レーザ加熱; 焼灼凝固; 胃治療; 医療福祉; 低侵襲治療法; 表面冷却法

A serial research from the fundamental to application has been conducted for developing novel method of non-invasive laser coagulation method. In the first experiment, absorption and transparency of laser in tissues and also thermal properties such as heat conductivity and diffusivity are measured for understanding and modeling the laser coagulation. The measurement was made for meats and tissues of the pig as the test material. To confirm the possibility of the present idea of coagulation, theoretical analysis of the temperature distribution in tissues when the laser irradiates and the surface of tissues is cooled by cold water. After the theoretical analysis, experiment of laser irradiation by employing meats as the test material was carried out and compared with the analytical results. In the experiments, water temperature, water flow rate, laser strength and laser irradiation time were changed to investigate the effects for the tissue coagulation. The theoretical and experimental results agree well each other. At the next stage, a prototype handy coagulation devise was designed and produced for the experiment of application. It is found that this device can apply well to the coagulation of meats. So we proceeded to the animal tests. Namely, at the last stage of the research, animal tests were conducted with an aim to apply the present method to the coagulation of stomach of the pig. The changes of the before and after laser irradiation were investigated in detail, and the size of the region of coagulated tissues was measured and the relation of the size to the experimental parameters such as laser power and irradiation time was made clear. With an aim to accumulate sufficient data and confirm the applicability of the present method, the animal tests are still conducting.

为开发一种新的无创激光凝固方法，进行了从基础到应用的一系列研究。在第一个实验中，激光在组织中的吸收和透明度，以及热性能，如导热率和扩散率进行测量，以了解和模拟激光凝固。对作为试验材料的猪肉和组织进行测量。为了证实该凝固设想的可行性，对激光照射组织并用冷水冷却组织表面时组织内的温度分布进行了理论分析。在理论分析后，以肉类为试验材料进行了激光辐照实验，并与分析结果进行了比较。实验中，通过改变水温、水流量、激光强度和激光照射时间，研究了对组织凝固的影响。理论和实验结果吻合较好。在此基础上，设计并制作了一台便携式混凝装置样机，进行了应用试验。实验结果表明，该装置可以很好地应用于肉类的凝固。所以我们进行了动物实验。也就是说，在研究的最后阶段，进行动物试验，目的是将本方法应用于猪胃的凝固。详细研究了激光照射前后组织凝固区的变化，测量了组织凝固区的大小，明确了凝固区大小与激光功率、照射时间等实验参数的关系。为了积累足够的数据并确认本方法的适用性，动物试验仍在进行中。

项目成果

前間篤,橋本大定,幕内雅敏,庄司正弘,横谷定雄,渡辺誠,福留寛樹: "レーザ加熱治療法開発の基礎研究"第35回日本伝熱シンポジウム講演論文集. 3. 841-842 (1998)

Atsushi Maema、Daisada Hashimoto、Masatoshi Makuuchi、Masahiro Shoji、Sadao Yokotani、Makoto Watanabe、Hiroki Fukudome：“激光加热疗法发展的基础研究”第 35 届日本传热研讨会论文集 3. 841-842（1998）。

前間篤,橋本大定,横谷定雄,庄司正弘,幕内雅敏: "表面温度制御法を用いたレーザー治療の基礎的研究-消化管病変に対する可能性-"第6回日本コンピュータ外科学会大会講演論文集. 55-56 (1997)

Atsushi Maema、Daisada Hashimoto、Sadao Yokotani、Masahiro Shoji、Masatoshi Makuuchi：“使用表面温度控制方法进行激光治疗的基础研究 - 胃肠道病变的可能性 -”第 6 届日本计算机外科学会会议上的演讲论文第 55-56 卷。 (1997)

幕内雅敏,橋本大定,庄司正弘,横谷定雄,渡辺誠: "低侵襲レーザ加熱治療法開発の基礎研究"第6回日本コンピュータ外科学会大会講演論文集. 53-54 (1997)

Masatoshi Makuuchi、Daisada Hashimoto、Masahiro Shoji、Sadao Yokotani、Makoto Watanabe：“微创激光加热治疗发展的基础研究”第 6 届日本计算机外科学会会议记录 53-54（1997 年）。

前間,橋本,横谷,庄司,幕内: "表面温度制御法を用いたレーザ治療の基礎的研究" 第6回日本コンピュータ外科学会大会講演論文集. 1. 55-56 (1997)

Maema、Hashimoto、Yokotani、Shoji、Makuuchi：“利用表面温度控制方法进行激光治疗的基础研究”第 6 届日本计算机外科学会会议记录 1. 55-56 (1997)。

前間篤,橋本大定,庄司正弘,横谷定雄,幕内雅敏: "表面温度制御法を用いた新しいレーザー治療法の開発-消化管に対する基礎研究-"第19回日本レーザ医学会大会講演論文集. 79 (1998)

Atsushi Maema、Daisada Hashimoto、Masahiro Shoji、Sadao Yokotani、Masatoshi Makuuchi：“利用表面温度控制方法开发新型激光治疗方法 - 胃肠道基础研究 -”第 19 届日本激光医学学会会议论文集 .79。 (1998)