HIGH INTENSITY ULTRASOUND FOR NON-INVASIVE SURGERY

用于非侵入性手术的高强度超声波

• 批准号: 6744797
• 负责人: Charles Alan Cain
• 金额: $ 29.7万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6744797
• 关键词: surgery; surgery material /equipment; technology /technique development; ultrasound therapy

DESCRIPTION (Adapted from Applicant's Abstract): Check thisWays to make acoustic cavitation predictable, and thus practical as a mechanism for noninvasive surgery, will be explored in this research. Novel ways to accurately place therapy beams and verifying that surgical lesions have been formed will also be explored. With the use of large aperture phased array systems, and aberration correction techniques, it is possible to form high quality ultrasound beams around and through obstructions like ribs, or the skull, with the attractive possibility of noninvasive brain surgery or cardiac ablation for treatment of life threatening arrhythmias. With the loss of energy in propagating around and through such obstructions, thermal ablation, without heating the complex intervening tissue, is a difficult proposition. However, cavitation, particularly from arrays operating at lower ultrasound frequencies, becomes an exciting tissue ablation mechanism for further study. Of particular interest is the potential use of stabilized microbubbles, often used as ultrasound imaging contrast agents, to act as cavitation nuclei lowering cavitation thresholds and making spatial localization predictable. Cavitation has been intentionally avoided in the past because reproducible localization of ablation zones (or surgical lesions) has been difficult mostly due to large unpredictable spatial variations in cavitation thresholds in living tissues. Preliminary experiments with phased array systems suggest that surgical lesion size and shape become more predictable with prior administration of contrast agents. The applicants proposed to systematically explore the role of contrast agents on cavitation thresholds, surgical lesion size and histology, predictability of shape and spatial localization of necrotic zones, and role of contrast agent concentration. Such systems will allow highly predictable beams to be formed non-invasively, for example, around the ribs onto a moving target, e.g. the heart. Contrast agents will also be explored as means for targeting therapy beams and as a way to verify that surgical lesions have been formed in the desired treatment volume. This application is based on their experimental observation that microbubbles can be "collapsed" by low intensity ultrasound causing "darker" areas in the image, thus allowing sub-lesion forming intensities to be used for beam localization prior to application of surgical intensities. Since cavitationally induced lesions will likely destroy the local vasculature, a surgically necrosed volume will not re-perfuse with contrast agent indicating lesion extent. The applicants will explore use of contrast agents as means to guide, enhance, and verify surgical lesion formation with high intensity ultrasound.

描述(改编自申请者摘要)：勾选此方式即可 声空化是可预测的，因此作为一种机制是可行的 非侵入性手术，将在本研究中探索。以新颖的方式 准确放置治疗光束并验证手术损伤是否已 也将对已形成的问题进行探索。使用大口径相控阵 系统和像差校正技术，有可能形成高 高质量的超声波在肋骨等障碍物周围或通过 颅骨，具有诱人的非侵入性脑外科手术或心脏手术的可能性 消融治疗危及生命的心律失常。随着能量的损失 在这些障碍物周围和通过这些障碍物传播时，热消融没有 加热复杂的中间组织，是一个困难的命题。然而， 空化，特别是在较低超声频率下工作的阵列， 成为一种激动人心的组织消融机制，有待进一步研究。特别的 人们感兴趣的是稳定的微泡的潜在用途，通常被用作 超声造影剂，起到空化核降低的作用 空化阈值，并使空间局部化可预测。空化 在过去被有意避免，因为可重复本地化 消融区(或手术损伤)一直很困难，主要是因为 活体组织中空化阈值的不可预测的空间变化。 相控阵系统的初步实验表明，外科损伤 通过预先实施对比，大小和形状变得更可预测 探员们。申请者建议系统地探索对比的作用。 空化阈值、手术损伤大小和组织学方面的试剂， 坏死区的形状和空间定位的可预测性，以及 造影剂浓度。这样的系统将允许高度可预测的波束 例如在肋骨周围非侵入性地形成到移动目标上， 例如心脏。还将探索造影剂作为靶向的手段 治疗光束，并作为一种验证外科损伤是否已在 所需的处理量。此应用程序基于他们的实验 低强度超声可使微泡“崩塌”的观察 导致图像中的“较暗”区域，从而允许形成亚病变 外科手术前用于射束定位的强度 强度。因为空洞导致的损伤很可能会破坏局部 血管系统，手术后坏死的体积不会在造影剂中重新灌流 指示损伤程度的试剂。申请者将探索对比的用法。 作为指导、增强和验证外科病变形成的手段的药物 高强度超声波。

项目成果

Aberration correction by nonlinear beam mixing: generation of a pseudo point sound source.

通过非线性光束混合进行像差校正：伪点声源的生成。

• DOI: 10.1109/tuffc.2005.1561666
• 发表时间: 2005
• 期刊: IEEE transactions on ultrasonics, ferroelectrics, and frequency control
• 作者: Seo,Jongbum;Choi,JJ;Fowlkes,JBrian;O'Donnell,Matthew;Cain,CharlesA
• 通讯作者: Cain,CharlesA

Evaluation of ultrasound tissue damage based on changes in image echogenicity in canine kidney.

基于犬肾脏图像回声变化的超声组织损伤评估。

• DOI: 10.1109/tuffc.2005.1503997
• 发表时间: 2005
• 期刊: IEEE transactions on ultrasonics, ferroelectrics, and frequency control
• 作者: Seo,Jongbum;Tran,BinhC;Hall,TimothyL;Fowlkes,JBrian;Abrams,GeraldD;O'Donnell,Matthew;Cain,CharlesA
• 通讯作者: Cain,CharlesA