Inhibitory effects of combination therapy of denosumab, anti-RANKL antibody, and biological DMARD on bone and cartilage destruction in patients with rheumatoid arthritis

地诺塞麦、抗RANKL抗体和生物DMARD联合治疗对类风湿性关节炎患者骨和软骨破坏的抑制作用

• 批准号: 26462290
• 负责人: Kojima Toshihisa
• 金额: $ 3.24万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2014
• 资助国家: 日本
• 起止时间: 2014-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462290/
• 关键词: rheumatoid arthritis; biologics; osteoporosis; denosumab; toll like receptor; 臨床; 関節リウマチ; 骨代謝; 生物学的製剤

项目成果

Predictive factors for achieving low disease activity at 52 weeks after switching from tumor necrosis factor inhibitors to abatacept: results from a multicenter observational cohort study of Japanese patients

从肿瘤坏死因子抑制剂转用阿巴西普后 52 周实现低疾病活动度的预测因素：日本患者多中心观察性队列研究的结果

• DOI: 10.1007/s10067-015-3135-3
• 发表时间: 2016
• 期刊: Clinical Rheumatology
• 影响因子: 3.4
• 作者: Kojima;T.;Takahashi;N.;Kaneko;A.;Kida;D.;Hirano;Y.;Fujibayashi;T.;Yabe;Y.;Takagi;H.;Oguchi;T.;Miyake;H.;Kato;T.;Watanabe;T.;Hayashi;M.;Shioura;T.;Kanayama;Y.;Funahashi;K.;Asai;S.;Yoshioka;Y.;Terabe;K.;Takemoto;T.;As
• 通讯作者: As

Hyaluronan Inhibits Tlr-4-Dependent RANKL Expression in Human Rheumatoid Arthritis Synovial Fibroblasts.

• DOI: 10.1371/journal.pone.0153142
• 发表时间: 2016
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Watanabe T;Takahashi N;Hirabara S;Ishiguro N;Kojima T
• 通讯作者: Kojima T

Mechanisms of Cartilage destruction in osteoarthritis and rheumatoid arthritis

骨关节炎和类风湿性关节炎软骨破坏的机制

• 发表时间: 2017
• 作者: Y.,Fujibayashi;T.,Sugiura;F.,Hayashi;M.,Funahashi;K.,Hanabayashi;M.,Asai;S.,Ishiguro;N.,Kojima;T.;小嶋俊久
• 通讯作者: 小嶋俊久

The Predictors for Twelve Months Efficacy of Denosumab, an Anti­RANKL Antibody, on Osteoporosis in Rheumatoid Arthritis Patients from Japanese Multicenter Study (TBCR­BONE)

抗地诺单抗 12 个月疗效的预测因子

• 发表时间: 2016
• 作者: Y. Hirano;Y. Kanayama;M. Isono;N. Ishiguro;T. Kojima;on behalf of TBCR-BONE
• 通讯作者: on behalf of TBCR-BONE

Montreal University(Canada)

蒙特利尔大学（加拿大）