Parietal epithelial cell activation and glomerulosclerosis: Mechanisms, mediators and clinical diagnosis ((3)-P17)

点击翻译按钮获取中文摘要

Building on our progress from the first funding periods, we will investigate the molecular and biophysical mechanism of glomerular hyperfiltration and glomerular hypertrophy as independent risk factors for parietal cell (PEC) activation and induction of glomerulosclerosis (FSGS). To improve diagnosis, we will identify and characterize novel biomarkers for PEC activation and single nephron glomerular filtration rate (SNGFR) in renal biopsies and in urine, respectively. Finally, we and others have identified an additional reservoir of podocytes on Bowman's capsule in newborn mammals. We will investigate whether recruitment of podocytes from this reservoir is regulated and whether it can be enhanced.