Bacterial vesicles transport their bioactive cargo to the host nucleus

细菌囊泡将其生物活性物质转运至宿主细胞核

• 批准号: DP210103881
• 负责人: Prof Richard Ferrero
• 金额: $ 30.21万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-03-30 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103881
• 关键词: Bacterial; vesicles; transport; their; bioactive

This project aims to investigate how bacterial membrane vesicles transport their cargo to the nucleus of cells and its impact on host cell functions. Bacteria use membrane vesicles as a means of communication with the host, but the full extent of their effects on host cells has yet to be fully elucidated. This project expects to generate new knowledge in the field using cutting-edge imaging and molecular biology approaches. The work should provide significant benefits, particularly towards the development of membrane vesicles in gene therapy, gene editing and other applications.

该项目旨在研究细菌膜囊泡如何将其货物运输到细胞核及其对宿主细胞功能的影响。细菌利用膜囊泡作为与宿主沟通的手段，但它们对宿主细胞的影响程度尚未完全阐明。该项目预计将使用尖端成像和分子生物学方法在该领域产生新的知识。这项工作应该会带来显着的好处，特别是对于基因治疗、基因编辑和其他应用中膜囊泡的开发。