NLRC5, a new regulator of Helicobacter-induced inflammation

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Helicobacter pylori lives in the stomach of half the world’s population and is a major cause of human disease, including cancer. The body fights H. pylori infection by mobilising white blood cells to the stomach lining, resulting in inflammation. We have evidence that H. pylori can attenuate this inflammation by targeting a host protein, NLRC5. This project will determine the role of NLRC5 in preventing inflammation and cancer due to H. pylori infection.