Unravelling cell wall polysaccharide biosynthesis in pathogenic zygomycetes

揭示致病接合菌细胞壁多糖的生物合成

• 批准号: DP210103779
• 负责人: Prof Vincent Bulone
• 金额: $ 35.39万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103779
• 关键词: Unravelling; cell; wall; polysaccharide; biosynthesis

This project aims to define mechanisms that control cell wall composition and stability in Rhizopus oryzae, a zygomycete fungus responsible for life-threatening human infections. The biochemical properties and function of vital enzymes involved in a newly discovered cell wall polysaccharide biosynthetic pathway will be determined using innovative approaches at the interface of biochemistry, microbiology, cell biology and structural biology. Expected outcomes include new knowledge on the enzymes that synthesise major fucose-based carbohydrates, to guide the future development of novel strategies for antifungal therapies. The data will also be applicable to animal protection from related zygomycete pathogens.

该项目旨在确定控制米根霉细胞壁组成和稳定性的机制，米根霉是一种接合真菌，负责威胁人类生命的感染。将在生物化学、微生物学、细胞生物学和结构生物学的界面上采用创新的方法来确定新发现的细胞壁多糖生物合成途径中涉及的重要酶的生化性质和功能。预期的结果包括关于合成主要岩藻糖碳水化合物的酶的新知识，以指导未来抗真菌治疗的新策略的发展。这些数据也将适用于动物保护，使其免受相关接合菌病原体的侵害。