Structure and metabolism of bioactive carbohydrates from brown algae

褐藻生物活性碳水化合物的结构和代谢

• 批准号: DP220103934
• 负责人: Prof Vincent Bulone
• 金额: $ 44.35万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-11-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103934
• 关键词: Structure; metabolism; bioactive; carbohydrates; brown

Brown algae produce a diversity of species-specific carbohydrates in their cell walls that exhibit a variety of biological activities that can be exploited for the development of functional food and biopharmaceutical formulations. However, the metabolic pathways responsible for the biosynthesis of these carbohydrates are poorly characterised. This multidisciplinary project aims to understand the molecular events that control the structure and metabolism of bioactive carbohydrates in the prominent Australian brown alga Ecklonia radiata, with particular focus on alginates and fucoidans. This knowledge will be used to produce in yeast bioactive oligosaccharides that are of high commercial interest to the biopharmaceutical industry.

褐藻在其细胞壁中产生多种物种特异性碳水化合物，这些碳水化合物表现出多种生物活性，可用于开发功能性食品和生物制药制剂。然而，负责这些碳水化合物的生物合成的代谢途径的特点很差。这个多学科项目旨在了解控制澳大利亚著名的棕色植物Ecklonia radiata中生物活性碳水化合物的结构和代谢的分子事件，特别关注藻酸盐和岩藻多糖。这些知识将用于在酵母中生产生物活性低聚糖，这对生物制药行业具有很高的商业利益。