Role of Pasteurella surface polysaccharides in pathogenesis and immunity

巴氏杆菌表面多糖在发病机制和免疫中的作用

• 批准号: DP210103610
• 负责人: Prof John Boyce
• 金额: $ 51.91万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-06-01 至 2024-05-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103610
• 关键词: Role; Pasteurella; surface; polysaccharides; pathogenesis

Livestock infections cause major economic losses worldwide. The bacterium Pasteurella multocida causes multiple diseases in a range of livestock, including hemorrhagic septicaemia in cattle and fowl cholera in poultry. Two surface polysaccharide structures, capsule and lipopolysaccharide, are crucial for P. multocida to cause disease. Our data indicate that varying the amount/content of these structures also affects vaccine performance. This project aims to identify how the production of these P. multocida structures are controlled and if changes to these structures affect its ability to infect different animals/birds. Using this information, the project aims to develop state-of-the-art livestock vaccines with superior disease coverage.

牲畜感染在全世界造成重大经济损失。多杀性巴氏杆菌在一系列牲畜中引起多种疾病，包括牛的出血性败血症和家禽的霍乱。多杀性巴氏杆菌的两种表面多糖结构，荚膜和脂多糖，是多杀性巴氏杆菌致病的关键。我们的数据表明，改变这些结构的量/含量也会影响疫苗性能。该项目旨在确定这些多杀性巴氏杆菌结构的产生是如何控制的，以及这些结构的变化是否会影响其感染不同动物/鸟类的能力。利用这些信息，该项目旨在开发具有上级疾病覆盖率的最先进的牲畜疫苗。