中空マイクロカプセルの製造および超音波造影剤と薬物伝達システムへの応用

空心微胶囊的生产及其在超声造影剂和药物输送系统中的应用

• 批准号: 13J06917
• 负责人: MOLINO CornejoJayJesus (2014)
• 金额: $ 1.15万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for JSPS Fellows
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13J06917/
• 关键词: Henry’s law constant; Organic solvents; Polymer concentration; Dissolution; Adsorption; Thermodynamics; Bubble dynamics; Surface chemistry; Solubility of gases; Bubble nucleation; Encapsulation

In the studies performed before April 2014, we discovered that changing the concentration of poly lactic acid (PLA) in a solution of PLA in dichloromethane yield to a change in the Henry’s law constant for nitrogen. This is crucial because if the solubility of gases in polymer solvents is an important consideration in removing volatile gases from the polymers, we have one more parameter available for designing microcellular/foam or for fabricating biodegradable hollow microcapsules and porous films, which is the final objective of our study.In the studies performed after April 2014, the effect of dissolved PLA on the solubility of gases (carbon dioxide, nitrogen, and helium) in dichloromethane was investigated, between 288 and 303 K, by measuring the equilibrium pressure in a closed vessel containing a gas and dichloromethane solutions of different types (molecular weights) and concentrations of PLA. The results showed that, in the absence of PLA, the order of the solubility of gases in dichloromethane was helium < nitrogen < carbon dioxide. Furthermore, an increase in the concentration of PLA did not appreciably change the solubility of carbon dioxide in the solutions, but led to a higher solubility of nitrogen and He. The effect of PLA on the increase of gas solubility in dichloromethane was larger for less soluble gases. Semi-empirical correlations of the dependence of the Henry’s law constant of the gases on the temperature and PLA concentration were also derived from the measured data.

在2014年4月之前进行的研究中，我们发现改变聚乳酸（PLA）二氯甲烷溶液中PLA的浓度会导致氮的亨利定律常数发生变化。这是至关重要的，因为如果气体在聚合物溶剂中的溶解度是从聚合物中去除挥发性气体的重要考虑因素，则我们还有一个参数可用于设计微孔/泡沫或制造可生物降解的中空微胶囊和多孔膜，这是我们研究的最终目标。在288和303 K之间，通过测量在含有气体和不同类型（分子量）和浓度的PLA的二氯甲烷溶液的密闭容器中的平衡压力，研究了在二氯甲烷中的（二氧化碳、氮气和氦气）。结果表明，在没有PLA存在的情况下，气体在二氯甲烷中的溶解度顺序为氦气<氮气<二氧化碳。此外，PLA浓度的增加并没有明显改变二氧化碳在溶液中的溶解度，但导致更高的溶解度的氮气和He。对于不太可溶的气体，PLA对增加气体在二氯甲烷中的溶解度的影响较大。气体的亨利定律常数对温度和PLA浓度的依赖关系的半经验关联式也来自于测量数据。

项目成果

Hollow polylactic acid microcapsules fabricated by gas/oil/water and bubble template methods

气/油/水和气泡模板法制备中空聚乳酸微胶囊

• DOI: 10.1039/c3ta12587d
• 发表时间: 2013
• 期刊: Journal of Materials Chemistry A
• 影响因子: 11.9
• 作者: Daichi Sakurai;Jay Jesus Molino;Hirofumi DaiguJi and Fumio Takemura
• 通讯作者: Hirofumi DaiguJi and Fumio Takemura

ポリマー発泡溶液を用いた中空マイクロカプセルの製造

利用聚合物泡沫溶液制备空心微胶囊

• 发表时间: 2015
• 作者: Daichi Sakurai;Jay Jesus Molino;Hirofumi DaiguJi and Fumio Takemura;西井奨;櫻井 大地，モリノ ジェイ，大宮司 啓文，竹村 文男
• 通讯作者: 櫻井 大地，モリノ ジェイ，大宮司 啓文，竹村 文男

Effect of Polylactic Acid Concentration on the Solubility of Gases in Dichloromethane

聚乳酸浓度对气体在二氯甲烷中溶解度的影响

• 发表时间: 2014
• 作者: Jay Jesus Molino;Daichi Sakurai;Hirofumi Daiguji;and Fumio Takemura
• 通讯作者: and Fumio Takemura