Harnessing sperm dynamics in microfluidic sorting technologies

在微流体分选技术中利用精子动力学

• 批准号: DP210103361
• 负责人: Prof Adrian Neild
• 金额: $ 24.19万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-02-25 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103361
• 关键词: Harnessing; sperm; dynamics; microfluidic; sorting

Mammalian reproductive tract is a complex microenvironment that has evolved to select the best sperm for fertilisation using a range of rheological, biochemical and geometrical cues. The project aims to engineer the first multiplexed platform, informed by the natural process, for fully automated and rapid selection of sperm based on all key selection criteria: morphology, swimming behaviour, and DNA integrity. The expected outcome is the next generation technology for sperm sorting and analysis. This should provide significant benefits, such as new biophysical insights into mammalian reproduction, with potential for future improvement of assisted reproduction technologies – a field in which Australia has a world leading history.

哺乳动物生殖道是一个复杂的微环境，它通过一系列的流变学、生物化学和几何学线索来选择最佳的精子进行受精。该项目旨在设计第一个多路复用平台，以自然过程为基础，根据所有关键选择标准（形态学，游泳行为和DNA完整性）进行全自动和快速的精子选择。预期的结果是下一代精子分选和分析技术。这将带来重大的好处，例如对哺乳动物生殖的新的生物物理见解，以及未来改进辅助生殖技术的潜力-澳大利亚在这一领域拥有世界领先的历史。