Acoustic single cell traps: Understanding the woods by examining the trees

声学单细胞陷阱：通过检查树木来了解森林

• 批准号: DP160101263
• 负责人: Prof Adrian Neild
• 金额: $ 25.22万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-05-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160101263
• 关键词: Acoustic; single; cell; traps; Understanding

This project aims to define the underlying physics behind the manipulation of individual cells in a microfluidic chip using acoustic forces. The technology investigated would offer biomedical researchers a unique capability: that of tracking individual cell responses. It is known for example that drug resistance and latency emerge from small sub-populations of cells, so crucial information is lost when cells are studied at a population level. To trap single cells, the acoustic wavelength excited must be reduced to the order of a cell diameter. By enabling the analysis of different responses due to subtle cell difference, information pertinent to infection pathways and drug response could be gathered.

该项目旨在定义使用声学力在微流体芯片中操纵单个细胞背后的基本物理学。这项研究的技术将为生物医学研究人员提供一种独特的能力：跟踪单个细胞的反应。例如，众所周知，耐药性和潜伏期来自小的细胞亚群，因此当在群体水平上研究细胞时，关键信息就会丢失。为了捕获单个细胞，激发的声波波长必须减小到细胞直径的量级。通过分析由于细微的细胞差异引起的不同反应，可以收集与感染途径和药物反应相关的信息。