Deciphering novel cross-talk between innate cytokine receptors

破译先天细胞因子受体之间的新型串扰

• 批准号: DP210103122
• 负责人: A/Prof Meredith O'Keeffe
• 金额: $ 64.92万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-06-30 至 2024-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210103122
• 关键词: Deciphering; novel; cross; talk; between

Understanding the basic functions of interferons, how they signal to cells, is central to understanding fundamental immunity. Interferons are crucial molecules of the immune system that are important for normal cell development and they protect the body from viral infection and cancer but can be deleterious in different autoimmune diseases and trauma settings. Preliminary Data shows there is a pathway of interferon signalling that has previously been overlooked. This project aims to understand how this pathway works and how it contributes to the normal workings of cells. This fundamental science has future consequences for the design of vaccines and for the design of therapeutics to treat diseases that show defective interferon signalling.

了解干扰素的基本功能，它们如何向细胞发出信号，是理解基本免疫的核心。干扰素是免疫系统的关键分子，对正常细胞发育很重要，它们保护身体免受病毒感染和癌症，但在不同的自身免疫性疾病和创伤环境中可能是有害的。初步数据显示，有一个干扰素信号通路，以前被忽视。该项目旨在了解这种途径如何工作以及它如何有助于细胞的正常工作。这一基础科学对疫苗的设计和治疗干扰素信号缺陷疾病的治疗方法的设计具有未来的影响。