Feasibility studies of SMILE (SMart Last-mILE cooling system) for the developed world

根据世卫组织的数据，在2019冠状病毒病之前，全球仍有2000万儿童无法获得基本疫苗接种，每年有200万至300万儿童死于疫苗可预防的疾病。在全球范围内，20-50%的疫苗被浪费，据报道，在偏远地区，85%的疫苗被破坏。其中一个原因是，在最后几英里的运送过程中（“最后一英里”），疫苗会因温度波动而受损。然而，在现场使用的疫苗载体基本上是冷箱，即装满冰袋的盒子。它们要么冷冻疫苗，要么在使用时只能维持一天。此外，人为错误和不正确的处理进一步加速了腐败。IDEABATIC的成立是为了解决资源有限的偏远地区的最后一英里冷链问题。我们创造了SMILE，这是一种获得专利的智能最后一英里冷却系统，可最大限度地减少人为错误，减少腐败并提高效率。一位资深科学家将其描述为“星际迷航疫苗机”。SMILE就像一个携带背包的坚固的便携式疫苗自动售货机，专为在崎岖的地形上旅行而设计。它是低技术含量和万无一失的。SMILE呈六边形，包含一个圆柱形的冰块，周围环绕着一个装有疫苗瓶的旋转木马系统。旋转木马也是一个空气锁定系统。一个自动关闭的门补充旋转木马，以尽量减少热量传递，即使门被反复打开。SMILE可在无电状态下持续使用3-6天，同时监测和显示剩余的冷却寿命。SMILE已经过反复测试、实验室测试和现场测试。2019年，我们在马达加斯加的偏远村庄进行了一次成功的试验。SMILE将有助于最后一英里的应用，但并不局限于在发展中国家使用。在全球范围内，冷箱被用于研究机构、生物医药公司和物流公司，这些地方也存在类似的问题。我们的创新解决方案需要评估，以了解它与发达国家客户及其工作环境的需求是否兼容。该项目的目的是调查发达世界（成熟）市场中SMILE可能产生影响的选定区域，并探索国际伙伴关系，并通过合作进入新市场。我们最近与阿联酋、日本和台湾的公司进行了交谈，他们对SMILE表示了兴趣。我们希望集中在这些地区进行评估，以加强我们的产品，并确定进入市场的主要途径。我们的最终目标是通过SMILE或其相关技术在全球范围内提高*疫苗覆盖（包括COVID-19）*样本采集*研究*冷链应用的效率。

According to the WHO, pre-COVID-19, 20 million children worldwide still had no access to basic vaccinations and 2 to 3 million children died each year of a vaccine-preventable disease. Globally, 20-50% of vaccines are wasted and in remote areas, 85% spoilage has been reported. One of the reasons is that during the last few miles of delivery ('last-mile') vaccines become damaged by temperature fluctuations .However, vaccine carriers used in the field are essentially cool boxes, i.e. boxes filled with icepacks. They either freeze vaccines or last barely a day when in use. Moreover, human error and incorrect handling further accelerate spoilage.IDEABATIC was established to solve these last-mile cold-chain issues in remote areas with limited resources. We created SMILE, a patented, SMart, last-mILE cooling system that minimises human error, reduces spoilage and improves efficiency. A senior scientist described it as a "Star Trek vaccine machine". SMILE is like a robust, portable vaccine vending machine with a backpack, designed for travel over rugged terrain. It is low-tech and fool-proof. Hexagonal in shape, SMILE contains a cylindrical ice block surrounded by a carousel system that holds vaccine vials. The carousel is also an air-locking system. A self-closing door complements the carousel to minimise heat transfer even when the door is opened repeatedly. SMILE can last for 3-6 days without power while monitoring and displaying the remaining cool-life. SMILE has been iterated, lab tested and field tested. We conducted a successful trial in remote villages in Madagascar in 2019\.SMILE will help in last-mile applications but is not limited to use in developing countries. Globally, cool boxes are used in research institutions, biomedical companies and logistics companies where similar issues persist. Our innovative solution requires evaluation to appreciate how compatible it is with the needs of developed-world customers and their working environments.The aims of this project are to investigate selected regions in the developed-world (mature) market where SMILE could make an impact and to explore international partnerships and gain access to new markets through collaboration.We recently spoke to companies in the UAE, Japan and Taiwan who have shown an interest in SMILE. We wish to focus on these regions for evaluation to strengthen our offering and identify the primary route to market.Our ultimate goal is to improve efficiency in:* vaccine coverage (including COVID-19)* sample collection* research* cold-chain applicationsby using SMILE or its related technologies globally.