Electrophysiological monitoring of a neuron cardiomyocyte co-culture device.

该项目旨在提高NeuroLoom的联合培养平台能力，以筛选对心脏的毒性影响的新疗法。国家物理实验室是英国计量研究所记录生物组织电信号的专家，他们将帮助NeuroLoom测量NeuroLoom微型设备中心脏细胞的活动，而微型设备中的神经系统细胞处于不同的活动水平。这将允许NeuroLoom的设备只有在心脏处于不同的活动状态时才能检测到药物何时有毒性作用。在不同的活动状态，如跑步与休息或惊慌与放松，心脏对药物的反应方式不同。使NeuroLoom的产品能够检测心脏细胞对药物的反应。检测到这种反应使药物开发人员避免将不必要的资金用于在人类或动物身上进行药物试验，并对试验参与者造成伤害。展示这一能力将通过每台设备产生更多收入并提供目前市场上没有的功能来提高NeuroLoom的生产率和竞争力。

This project aims to improve Neuroloom's co-culture platform ability to screen novel therapies for toxic effects on the heart. The experts in recording electrical signals from biological tissue at the UK's metrology Institute, the National Physical Lab will assist Neuroloom in measuring the activity of the heart cells in Neuroloom's microdevice whilst the nervous systems cell in the microdevice are at different levels of activity. This will allow Neuroloom's device to detect when a drug has a toxic effect only when the heart is in different states of activity. During different state of activity, e.g. running versus resting or panicking versus relaxing, the heart responds to drugs in different ways. Enabling Neuroloom's product to detect the response of the heart cells to drugs. Detecting this response allows drug developers to avoid spending unnecessary money on trialing drugs on humans or animals and cause harm to the trial participants. Demonstrating this capability will improve both Neuroloom's productivity and competitiveness by generating more revenue per device and offering a capability not currently available on the market.