Electrophysiological monitoring of a neuron cardiomyocyte co-culture device.

神经元心肌细胞共培养装置的电生理监测。

• 批准号: 10022250
• 金额: $ 2.16万
• 依托单位: NEUROLOOM LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=10022250
• 关键词: Electrophysiological; monitoring; neuron; cardiomyocyte; co

This project aims to improve Neuroloom's co-culture platform ability to screen novel therapies for toxic effects on the heart. The experts in recording electrical signals from biological tissue at the UK's metrology Institute, the National Physical Lab will assist Neuroloom in measuring the activity of the heart cells in Neuroloom's microdevice whilst the nervous systems cell in the microdevice are at different levels of activity. This will allow Neuroloom's device to detect when a drug has a toxic effect only when the heart is in different states of activity. During different state of activity, e.g. running versus resting or panicking versus relaxing, the heart responds to drugs in different ways. Enabling Neuroloom's product to detect the response of the heart cells to drugs. Detecting this response allows drug developers to avoid spending unnecessary money on trialing drugs on humans or animals and cause harm to the trial participants. Demonstrating this capability will improve both Neuroloom's productivity and competitiveness by generating more revenue per device and offering a capability not currently available on the market.

该项目旨在提高Neuroloom的共培养平台筛选心脏毒性作用新疗法的能力。来自英国计量研究所的记录生物组织电信号的专家，国家物理实验室将协助Neuroloom测量微设备中心脏细胞的活动，同时微设备中的神经系统细胞处于不同的活动水平。这将允许Neuroloom的设备仅在心脏处于不同活动状态时检测药物何时具有毒性作用。在不同的活动状态下，例如跑步与休息，恐慌与放松，心脏对药物的反应方式不同。使Neuroloom的产品能够检测心脏细胞对药物的反应。检测这种反应可以让药物开发人员避免在人类或动物身上进行药物试验时花费不必要的钱，从而避免对试验参与者造成伤害。展示这种能力将提高Neuroloom的生产力和竞争力，通过每台设备产生更多的收入，并提供目前市场上没有的功能。