A simple, multivalent vaccine to prevent Zika and Chikungunya: progression and readiness to phase II trial
一种预防寨卡和基孔肯雅热的简单多价疫苗:二期试验的进展和准备情况
基本信息
- 批准号:10025262
- 负责人:
- 金额:$ 63.33万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Small Business Research Initiative
- 财政年份:2022
- 资助国家:英国
- 起止时间:2022 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The aim of this project is to progress the clinical development of a new bivalent vaccine that judiciously induces simultaneous protection against Zika and chikungunya viruses (ZIKV and CHIKV). These two diseases are transmitted by the same mosquito specie as dengue, therefore causing a severe disease burden in the same geographical regions and in the same populations, particularly in low-and-middle-income countries. There is currently no vaccine to prevent Zika or chikungunya infections, and while any one vaccine would be particularly useful to reduce the disease burden in these vulnerable populations, a bivalent vaccine would further support global health by simplifying vaccination campaigns at lower costs when compared to single vaccine campaigns. Infection by ZIKV is a major concern worldwide due to causing neurologic conditions, such as Guillain-Barré syndrome and a 20-fold increase in the incidence of neonatal microcephaly. Infection by CHIKV results in a flu-like symptomatic disease in approximately three quarters of infected people, and may lead to painful and debilitating long-term arthritis in patients of all ages. Persistent arthritis may last for years causing disability and inability to work. Long-term sequelae and lack of specific treatment for ZIKV and CHIKV infections contribute to poverty and high costs for families and governments in areas where the health system is weak and already overwhelmed by other arbovirus diseases such as dengue or by unrelated outbreaks such as SARS-CoV-2\. Socioeconomical factors such as poverty and migration, together with climate change, increase the geographical regions where the mosquitoes live and transmit the viruses. A major breakthrough and an ideal preventive solution would be to provide a bivalent vaccine to simultaneously fight Zika and chikungunya. This proposal aims to leverage the findings and samples collected during a Phase Ib trial that has been completed in Mexico, where both diseases are prevalent. This 12-month project will enable the partners to advance the technical tools and collaborations ready for a phase IIb clinical trial.
该项目的目的是推进一种新的二价疫苗的临床开发,这种疫苗可以明智地同时诱导对寨卡病毒和基孔肯雅病毒(寨卡病毒和基孔肯雅病毒)的保护。这两种疾病与登革热由同一种蚊子传播,因此在同一地理区域和同一人群中,特别是在低收入和中等收入国家,造成了严重的疾病负担。目前还没有预防寨卡病毒或基孔肯雅热感染的疫苗,虽然任何一种疫苗都对减轻这些脆弱人群的疾病负担特别有用,但与单一疫苗接种相比,二价疫苗将以更低的成本简化疫苗接种活动,从而进一步支持全球卫生。寨卡病毒感染是世界范围内的一个主要问题,因为它会引起格林-巴罗综合征等神经系统疾病,并使新生儿小头畸形的发病率增加20倍。大约四分之三的受感染人群感染后会出现流感样症状,并可能导致所有年龄的患者出现疼痛和使人衰弱的长期关节炎。持续性关节炎可能持续数年,导致残疾和无法工作。在卫生系统薄弱且已经被登革热等其他虫媒病毒疾病或SARS-CoV-2等无关疫情所淹没的地区,寨卡病毒和CHIKV感染的长期后遗症和缺乏特异性治疗导致了贫困和家庭和政府的高额费用。贫穷和移徙等社会经济因素,加上气候变化,增加了蚊子生活和传播病毒的地理区域。一项重大突破和一种理想的预防性解决方案将是提供一种同时对抗寨卡病毒和基孔肯雅热的双价疫苗。该提案旨在利用在墨西哥完成的Ib期试验期间收集的发现和样本,这两种疾病都很普遍。这个为期12个月的项目将使合作伙伴能够推进技术工具和合作,为IIb期临床试验做好准备。
项目成果
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专利数量(0)
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其他文献
Internet-administered, low-intensity cognitive behavioral therapy for parents of children treated for cancer: A feasibility trial (ENGAGE).
针对癌症儿童父母的互联网管理、低强度认知行为疗法:可行性试验 (ENGAGE)。
- DOI:
10.1002/cam4.5377 - 发表时间:
2023-03 - 期刊:
- 影响因子:4
- 作者:
- 通讯作者:
Differences in child and adolescent exposure to unhealthy food and beverage advertising on television in a self-regulatory environment.
在自我监管的环境中,儿童和青少年在电视上接触不健康食品和饮料广告的情况存在差异。
- DOI:
10.1186/s12889-023-15027-w - 发表时间:
2023-03-23 - 期刊:
- 影响因子:4.5
- 作者:
- 通讯作者:
The association between rheumatoid arthritis and reduced estimated cardiorespiratory fitness is mediated by physical symptoms and negative emotions: a cross-sectional study.
类风湿性关节炎与估计心肺健康降低之间的关联是由身体症状和负面情绪介导的:一项横断面研究。
- DOI:
10.1007/s10067-023-06584-x - 发表时间:
2023-07 - 期刊:
- 影响因子:3.4
- 作者:
- 通讯作者:
ElasticBLAST: accelerating sequence search via cloud computing.
ElasticBLAST:通过云计算加速序列搜索。
- DOI:
10.1186/s12859-023-05245-9 - 发表时间:
2023-03-26 - 期刊:
- 影响因子:3
- 作者:
- 通讯作者:
Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly.
使用通过嵌段共聚物自组装制造的 2D 金纳米结构阵列放大 EQCM-D 检测细胞外囊泡。
- DOI:
10.1039/d2nh00424k - 发表时间:
2023-03-27 - 期刊:
- 影响因子:9.7
- 作者:
- 通讯作者:
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{{ truncateString('', 18)}}的其他基金
An implantable biosensor microsystem for real-time measurement of circulating biomarkers
用于实时测量循环生物标志物的植入式生物传感器微系统
- 批准号:
2901954 - 财政年份:2028
- 资助金额:
$ 63.33万 - 项目类别:
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Exploiting the polysaccharide breakdown capacity of the human gut microbiome to develop environmentally sustainable dishwashing solutions
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- 批准号:
2896097 - 财政年份:2027
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$ 63.33万 - 项目类别:
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A Robot that Swims Through Granular Materials
可以在颗粒材料中游动的机器人
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2780268 - 财政年份:2027
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$ 63.33万 - 项目类别:
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Likelihood and impact of severe space weather events on the resilience of nuclear power and safeguards monitoring.
严重空间天气事件对核电和保障监督的恢复力的可能性和影响。
- 批准号:
2908918 - 财政年份:2027
- 资助金额:
$ 63.33万 - 项目类别:
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Proton, alpha and gamma irradiation assisted stress corrosion cracking: understanding the fuel-stainless steel interface
质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
- 批准号:
2908693 - 财政年份:2027
- 资助金额:
$ 63.33万 - 项目类别:
Studentship
Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
- 批准号:
2908917 - 财政年份:2027
- 资助金额:
$ 63.33万 - 项目类别:
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Assessment of new fatigue capable titanium alloys for aerospace applications
评估用于航空航天应用的新型抗疲劳钛合金
- 批准号:
2879438 - 财政年份:2027
- 资助金额:
$ 63.33万 - 项目类别:
Studentship
CDT year 1 so TBC in Oct 2024
CDT 第 1 年,预计 2024 年 10 月
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2879865 - 财政年份:2027
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Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in
使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型,以分析白细胞介素 17 抑制剂的细胞和表观遗传效应
- 批准号:
2890513 - 财政年份:2027
- 资助金额:
$ 63.33万 - 项目类别:
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Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
了解野生鸟类肠道微生物组、行为和城市化之间的相互作用
- 批准号:
2876993 - 财政年份:2027
- 资助金额:
$ 63.33万 - 项目类别:
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