Bone Regenerating Knee Implants for Long Term Bone Health

NHS每年进行13万例膝关节置换手术。由于我们的人口老龄化和新冠肺炎造成的积压，需求正在增长。膝关节部分手术是增长最快的治疗方法，尤其是在年轻患者中，对他们来说，变得不那么活跃、更有生产力和社会人脉的风险更高，而且会产生更严重的长期后果。尽管在骨科植入物方面取得了进展，但目前固体钴铬植入物仍然是治疗膝骨性关节炎的黄金标准。这种材料的一个主要缺点是从长远来看，它会降低骨健康，从而导致骨丢失和种植体松动。现有的部分膝关节胫骨假体显示出良好的患者预后，然而，它们干扰了骨骼的自然动态重塑，因为它们是由固体钴铬制成的。此外，30%的银行因松动而失败。这种植入物使70%的骨面积负荷不足，并抑制骨生长，使翻修手术复杂化。我们的3D打印组件集成了我们独特的多孔结构，身体和动物数据表明，这种结构比传统植入物更好地保持了骨负荷和健康。恢复生理负荷将刺激种植体周围的长期骨生长，并通过骨向多孔种植体内长入来实现长期的生物固定。我们的植入物将是第一个具有聚合物对聚合物关节表面的部分膝关节置换，它消除了过敏反应的风险。我们预计，这种植入物可以为NHS节省终身成本，更广泛地说，有助于保持年轻男性和女性随着年龄的增长而保持活跃、高效、独立和社交-享受更多的工作和有益的个人生活。就业机会如此之多，平均而言，关节炎患者的收入低于非关节炎患者。此外，事实证明，由于寻求预防性治疗的机会减少和公共部门等待时间延长，对较贫穷的患者来说，疾病的管理明显更加困难。部分膝关节置换术提供日间手术治疗和比全膝关节置换术更快的恢复。从护理角度和长期来看，它们也更具成本效益。我们的植入物将通过降低并发症的风险来改善这一点。这样，我们的服务将确保为所有患者提供负担得起的及时治疗，从而有助于缩小最富有和最贫穷人群的经历之间的差距。

The NHS performs 130,000 knee replacements annually. Demand is growing due to our ageing population and backlog caused by Covid-19\. Partial knee surgery is the fastest growing treatment, particularly in young patients for whom the risk of becoming less active, productive and socially connected is higher and has more severe long term consequences. Despite advances in orthopaedic implants, at present solid cobalt-chrome implants remain the gold-standard treatment for knee osteoarthritis. A major drawback of this material is that it diminishes bone health in the long term which can lead to bone loss and implant loosening. Existing partial knee tibial components show good patient outcomes, however, they disturb bone's natural dynamic remodelling because they are made from solid Cobalt Chrome. Additionally, 30% of them fail by loosening. Such implants under-load 70% of the bone area and inhibit bone growth, complicating revision surgery. Our 3D printed components integrate our unique porous structure which cadaveric and animal data indicates maintains bone loading and health better than conventional implants. Restoring physiological loading will stimulate long term bone growth around the implant and long-term biologic fixation via bone ingrowth into the porous implant. Our implant will be the first partial knee replacement with a polymer-on-polymer articulating surface, which removes the risk of allergenic response.We foresee this implant saving on lifetime costs for the NHS and more broadly, helping to keep young men and women active, productive, independent and socially connected as they age -- enjoying added years in work and a rewarding personal life. Employment opportunities are such that on average patients with arthritis earn less than those without. Furthermore, management of the disease has proven significantly more difficult for poorer patients, due to reduced opportunity to seek preventative treatment and longer public sector wait times. Partial knee replacements offer day surgery treatment and faster recovery than total knee replacement. They are also more cost effective at the point of care and over the long term. Our implants will improve this upon this by reducing risk of complication. In this way, our service will help to narrow the gap between the experience of the richest and poorest by ensuring affordable and timely treatment for all patients.