Dopaminergic modulation of nucleus accumbens during prospective and retrospective neuroeconomic decision making
前瞻性和回顾性神经经济决策过程中伏隔核的多巴胺能调节
基本信息
- 批准号:10151685
- 负责人:
- 金额:$ 5.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-31 至 2025-11-29
- 项目状态:未结题
- 来源:
- 关键词:AdultAnimalsAreaBehaviorBehavioralBiosensorBudgetsCellsClinicalCollaborationsColorComplexComputer AnalysisComputing MethodologiesDataDecision MakingDevelopmentDopamineDopamine D1 ReceptorDopamine D2 ReceptorEconomicsEvaluationEventFiberFunctional disorderFutureGoalsHumanInstructionInvestmentsKnowledgeLearningLightLiteratureMeasuresMental DepressionMental disordersMentorsMethodsMindMonitorMotivationMusNeurobiologyNeuronsNeurosciencesNeurotransmittersNucleus AccumbensObsessive-Compulsive DisorderOpsinOutcomePathologyPerformancePhotometryPhysiciansPlayPopulationProcessPsyche structurePsychiatryResearchResolutionRestaurantsRewardsRodentRoleSchizophreniaScientistSignal TransductionSynapsesSystemTechniquesTimeTrainingVentral Tegmental AreaVirusWorkbasebehavior measurementcalcium indicatorcareercollaborative environmentcostexperienceexperimental studyin vivoin vivo monitoringinformation processinginnovationneural correlateneurochemistryneuroeconomicsneuromechanismneuropsychiatric disorderneuropsychiatryneurotransmitter releasenonhuman primateoptogeneticspostsynapticprospectiverelating to nervous systemsignal processingskillsspatiotemporalsymptomatologytool
项目摘要
PROJECT SUMMARY
In 2017, it was estimated that nearly 20% of the adult population in the U.S. live with a mental illness, yet much
remains unknown about the pathophysiology of psychiatric disease and the specific behavioral symptomatology.
Aberrations in decision making and information processing have been implicated in neuropsychiatric diseases
like schizophrenia, obsessive-compulsive disorders, and depression. Importantly,
dysregulations in nucleus accumbens core (NAc core) dopamine signaling onto medium spiny neurons (MSNs)
constitute a key neural mechanism underlying these aberrant processes. Currently, NAc core research
disproportionately focuses on the motivation and reward-learning aspects of decision making. There is, however,
strong evidence that decision making involves more complex information-processing: making a decision requires
evaluation of actual outcomes but also requires prospection and retrospection on imagined alternate outcomes.
Therefore, it is important to investigate the role of dopamine release and MSN activity in information processing
when agents prospectively imagine potential outcomes before making a decision through deliberation and when
agents retrospectively imagine what could have been in the “path untraveled” (counterfactual reasoning) or
imagine poor time investments (sunk cost processing) after making a decision through reevaluation. Our
understanding of how NAc core dopamine encodes these imagined outcomes during prospective deliberation
and retrospective reevaluation is lacking greatly because there have not been behavioral tools with the
complexity to probe the mechanisms contributing to this type of information-processing in rodents. Innovative
work in the Redish lab has led to the development of a rodent behavioral task, called Restaurant Row, whose
intricacy allows for in-depth behavioral analysis of neuroeconomic behaviors. This proposal aims to elucidate
how NAc core dopamine dynamics reflect deliberation, counterfactual reasoning and sunk cost evaluation by 1)
simultaneous monitoring of in vivo dopamine release and MSN activity using fiber photometry 2) manipulating
endogenous dopamine signaling at specific points in decision making. Restaurant Row has tremendous
translational potential and has been adapted for non-human primates and humans. Thus, the work proposed
here will contribute to a larger translational collaboration in the future to investigate these questions across
species through collaboration with my clinical mentors in the Department of Psychiatry. My advisors Dr. David
Redish and Dr. Patrick Rothwell are equipped to mentor me both technically and professionally and together we
have curated a training plan that perfectly aligns with my career goals. By incorporating pioneering techniques
into a translational project in such an interdisciplinary environment will provide the training I need to develop
become a successful physician-scientist contributing to the field of computational psychiatry.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Adrine Kocharian其他文献
Adrine Kocharian的其他文献
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{{ truncateString('Adrine Kocharian', 18)}}的其他基金
Dopaminergic modulation of nucleus accumbens during prospective and retrospective neuroeconomic decision making
前瞻性和回顾性神经经济决策过程中伏隔核的多巴胺能调节
- 批准号:
10620634 - 财政年份:2021
- 资助金额:
$ 5.03万 - 项目类别:
Dopaminergic modulation of nucleus accumbens during prospective and retrospective neuroeconomic decision making
前瞻性和回顾性神经经济决策过程中伏隔核的多巴胺能调节
- 批准号:
10394126 - 财政年份:2021
- 资助金额:
$ 5.03万 - 项目类别:
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