16th International Conference on Limb Development and Regeneration

摘要 脊椎动物的肢体是发育、进化和再生的主要模型之一。 以肢体为中心的研究在过去几十年里蓬勃发展，这在很大程度上要归功于生物学的广度 假肢可以解决的问题，以及该模型在许多不同物种中进行实验的简便性。大有可为 关于肢体原基如何发育成复杂的多组织背后的细胞和分子生物学 致力于了解肢体的科学家已经阐明了这种肢体的结构。此外，已经取得了许多进展 关于如何正确形成四肢的遗传学，以及这种情况如何随着进化而改变 压力，以及这与人类先天疾病的关系。重要的是，仍然存在一些悬而未决的问题 我们现在正处于一个尖端，最终要在更深、更细的水平上完全理解这些过程 比以往任何时候都要好。最近的技术发展允许探测单个细胞的基因表达， 定义推动细胞和组织水平决策的染色质架构，使其具有意义 跨不同物种的分子比较，以及了解物理环境如何与 细胞。这些新技术在肢体模型中的应用正在改变这一领域。 在过去的30年里，一个专注于肢体的国际研究小组召开了 每两年举行一次肢体发育和再生国际会议。这次会议以压倒性的成绩 来自世界各地的科学家将花4天时间沉浸在围绕肢体的最新研究中 发展、再生和进化。本次大会第十六次会议定于8月9日至12日举行， 2021年，在马萨诸塞州剑桥市的哈佛大学校园里。这次会议将有一个开幕的 注册，预计将吸引150多名参与者。它将有三位主旨演讲者(代表 肢体进化、发育和再生)，20多位特邀演讲者和30多位演讲者 从参与者摘要中挑选。值得注意的是，除主旨之外的所有演讲都将是相同的长度，允许 实习生和初级调查人员展示他们的想法和进展，尽可能多地花时间 调查人员。整个计划将按性别和成员的参与情况进行平衡 将通过几条计划路线鼓励代表性不足的团体。财政支持正在进行 设法抵消会议场地和受邀演讲者的旅费。部分支持还将 用于为受训人员和人数不足的群体提供旅行援助。这次会议共同-- 组织者是杰西卡·莱霍茨基，博士(布里格姆妇女医院/哈佛医学院)和杰西卡 怀特博士(哈佛大学)；两人都是肢体再生领域的研究人员。

ABSTRACT The vertebrate limb stands as one of the premier models of development, evolution, and regeneration. Limb-focused research has flourished over past several decades, largely owing to the breadth of biological questions the limb can address and the ease of experimentation of the model in many diverse species. Much of the cellular and molecular biology behind how the limb primordia develops into a complex, multi-tissue structure has been elucidated by scientists dedicated to understanding the limb. Moreover, much progress has been made on understanding the genetics of how limbs form properly, how this can change with evolutionary pressure, and how this relates to human congenital diseases. Importantly, there are still outstanding questions and we are now on the cusp to finally fully understand these processes at a deeper and more granular level than ever before. Recent technological developments allow for probing the gene expression of individual cells, defining the chromatin architectures that drive cellular- and tissue-level decisions, making meaningful molecular comparisons across diverse species, and understanding how the physical environment interacts with cells. Applications of these new technologies within limb models is transforming the field. For over the past 30 years, an international group of researchers focused on the limb convene biennially for the International Conference on Limb Development and Regeneration. This meeting draws top scientists from across the globe to spend 4 days immersed in the newest research surrounding limb development, regeneration and evolution. The 16th meeting of this conference is scheduled for August 9th-12th, 2021, on the campus of Harvard University in Cambridge, Massachusetts. This meeting will have an open registration and is expected to draw over 150 participants. It will feature three keynote speakers (representing each of limb evolution, development, and regeneration), over 20 invited speakers, and over 30 speakers chosen from participant abstracts. Notably, all talks other than the keynotes will be the same length, allowing trainees and junior investigators to showcase their ideas and progress with as much time as more established investigators. The overall program will be balanced by gender, and participation by members of underrepresented groups will be encouraged through several planned routes. Financial support is being sought to offset the costs of conference venue and travel for invited speakers. A portion of the support will also be allocated toward travel assistance for trainees and underrepresented groups. The conference co- organizers are Jessica Lehoczky, PhD (Brigham & Women’s Hospital/Harvard Medical School) and Jessica Whited, PhD (Harvard University); both are investigators in the field of limb regeneration.