16th International Conference on Limb Development and Regeneration
第16届国际肢体发育与再生会议
基本信息
- 批准号:10151847
- 负责人:
- 金额:$ 1.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-05-01 至 2023-04-30
- 项目状态:已结题
- 来源:
- 关键词:AddressAnatomyAnimal ModelArchitectureBiologicalBiologyCellsChromatinCollaborationsCommunitiesComplexDataDecision MakingDevelopmentDiseaseDoctor of PhilosophyEvolutionExperimental ModelsFinancial SupportFutureGenderGene ExpressionGeneticGenomicsGoalsGrowthHealthHospitalsHumanIndividualInstitutionInternationalLengthLimb DevelopmentLimb structureMassachusettsModelingMolecularMolecular GeneticsMolecular and Cellular BiologyNatural regenerationOnline SystemsParticipantPatternPhysical environmentProcessResearchResearch PersonnelResourcesRouteScheduleScientistStructureTechniquesTechnologyTimeTissuesTranscriptional RegulationTravelUnderrepresented PopulationsUniversitiesVariantWomancareercostdata exchangeinsightlimb regenerationmedical schoolsmeetingsmembermodel developmentnew technologypressureprogramssymposiumtissue regenerationtooltraining opportunity
项目摘要
ABSTRACT
The vertebrate limb stands as one of the premier models of development, evolution, and regeneration.
Limb-focused research has flourished over past several decades, largely owing to the breadth of biological
questions the limb can address and the ease of experimentation of the model in many diverse species. Much
of the cellular and molecular biology behind how the limb primordia develops into a complex, multi-tissue
structure has been elucidated by scientists dedicated to understanding the limb. Moreover, much progress has
been made on understanding the genetics of how limbs form properly, how this can change with evolutionary
pressure, and how this relates to human congenital diseases. Importantly, there are still outstanding questions
and we are now on the cusp to finally fully understand these processes at a deeper and more granular level
than ever before. Recent technological developments allow for probing the gene expression of individual cells,
defining the chromatin architectures that drive cellular- and tissue-level decisions, making meaningful
molecular comparisons across diverse species, and understanding how the physical environment interacts with
cells. Applications of these new technologies within limb models is transforming the field.
For over the past 30 years, an international group of researchers focused on the limb convene
biennially for the International Conference on Limb Development and Regeneration. This meeting draws top
scientists from across the globe to spend 4 days immersed in the newest research surrounding limb
development, regeneration and evolution. The 16th meeting of this conference is scheduled for August 9th-12th,
2021, on the campus of Harvard University in Cambridge, Massachusetts. This meeting will have an open
registration and is expected to draw over 150 participants. It will feature three keynote speakers (representing
each of limb evolution, development, and regeneration), over 20 invited speakers, and over 30 speakers
chosen from participant abstracts. Notably, all talks other than the keynotes will be the same length, allowing
trainees and junior investigators to showcase their ideas and progress with as much time as more established
investigators. The overall program will be balanced by gender, and participation by members of
underrepresented groups will be encouraged through several planned routes. Financial support is being
sought to offset the costs of conference venue and travel for invited speakers. A portion of the support will also
be allocated toward travel assistance for trainees and underrepresented groups. The conference co-
organizers are Jessica Lehoczky, PhD (Brigham & Women’s Hospital/Harvard Medical School) and Jessica
Whited, PhD (Harvard University); both are investigators in the field of limb regeneration.
摘要
脊椎动物的肢体是发育、进化和再生的主要模型之一。
在过去的几十年里,以肢体为重点的研究蓬勃发展,这主要归功于生物学的广泛性。
肢体可以解决的问题以及在许多不同物种中进行模型实验的容易性。多
肢体原基如何发育成复杂的多组织的细胞和分子生物学
致力于了解肢体的科学家们已经阐明了这一结构。此外,
在理解四肢如何正常形成的遗传学基础上,这如何随着进化而改变,
压力,以及这与人类先天性疾病的关系。重要的是,
我们现在正处于最终在更深更细的层次上完全理解这些过程的风口浪尖上
比以往任何时候都要好。最近的技术发展允许探测单个细胞的基因表达,
定义驱动细胞和组织水平决策的染色质结构,
不同物种之间的分子比较,并了解物理环境如何与
细胞这些新技术在肢体模型中的应用正在改变这一领域。
在过去的30年里,一个国际研究小组专注于肢体召集
每两年举办一次肢体发育和再生国际会议。本次会议提请顶端
来自地球仪的科学家们将花4天时间沉浸在围绕肢体的最新研究中,
发展、再生和进化。本次大会第十六次会议定于8月9日至12日举行,
2021年,在马萨诸塞州剑桥的哈佛大学校园里。本次会议将有一个开放的
预计将有150多人参加。会议将有三位主讲人(代表
肢体进化、发育和再生),20多位特邀演讲者,30多位演讲者
从参与者摘要中选出。值得注意的是,除了基调之外,所有演讲的长度都是一样的,
学员和初级调查员展示他们的想法和进展尽可能多的时间,因为更建立
investigators.整个方案将按性别平衡,
将通过几条计划路线鼓励代表性不足的群体。财政支持正在
设法抵消会议地点和应邀发言者的旅费。一部分支持也将
为受训人员和代表人数不足的群体提供旅行援助。会议共同-
组织者是Jessica Leebrzky博士(布里格姆妇女医院/哈佛医学院)和Jessica
Whited博士(哈佛大学);两人都是肢体再生领域的研究人员。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jessica A Lehoczky其他文献
Jessica A Lehoczky的其他文献
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{{ truncateString('Jessica A Lehoczky', 18)}}的其他基金
Cellular plasticity and lineage in mammalian digit tip regeneration
哺乳动物指尖再生的细胞可塑性和谱系
- 批准号:
10675760 - 财政年份:2022
- 资助金额:
$ 1.9万 - 项目类别:
Investigation into establishing morphology during mouse digit tip regeneration, in the context of vertebrate limb development
在脊椎动物肢体发育的背景下研究小鼠指尖再生过程中形态的建立
- 批准号:
9753331 - 财政年份:2018
- 资助金额:
$ 1.9万 - 项目类别:
Regressive evolution of pigmentation in the Mexican cavefish, Astyanax mexicanus
墨西哥穴居鱼 Astyanax mexicanus 色素沉着的退化进化
- 批准号:
7613485 - 财政年份:2008
- 资助金额:
$ 1.9万 - 项目类别:
Regressive evolution of pigmentation in the Mexican cavefish, Astyanax mexicanus
墨西哥穴居鱼 Astyanax mexicanus 色素沉着的退化进化
- 批准号:
7789550 - 财政年份:2008
- 资助金额:
$ 1.9万 - 项目类别:
Regressive evolution of pigmentation in the Mexican cavefish, Astyanax mexicanus
墨西哥穴居鱼 Astyanax mexicanus 色素沉着的退化进化
- 批准号:
7480665 - 财政年份:2008
- 资助金额:
$ 1.9万 - 项目类别:
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