Investigating Alternative Nuclear Reactions for Medical Isotope Production

研究医用同位素生产的替代核反应

• 批准号: 10155519
• 负责人: Jennifer Anne Shusterman
• 金额: $ 15.6万
• 依托单位: HUNTER COLLEGE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2021-08-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10155519
• 关键词: Clinical; Communities; Community Medicine; Complement; Cyclotrons; Development; Diagnostic; Discipline of Nuclear Medicine; Future; Geometry; Heavy Ions; Helium; Isotopes; Laboratory Study; Linear Accelerator Radiotherapy Systems; Malignant Neoplasms; Measurement; Measures; Medical; Medicine; Methods; Neutrons; Nuclear; Nuclear Reactors; Parents; Pathway interactions; Patients; Potassium; Probability; Production; Protons; Radioactive; Radiochemistry; Radioisotopes; Reaction; Research; Route; Sodium Chloride; Techniques; Therapeutic; Thick; Translating; Translational Research; Work; accelerator mass spectrometry; clinical application; deuteron; interest; irradiation; laboratory development; particle beam; prevent; radiochemical; research study

Investigating Alternative Nuclear Reactions for Medical Isotope Production ABSTRACT The array of radionuclides used for, or considered as good candidates for, nuclear medicine has expanded in recent years. Of these radionuclides 44Sc and 67Cu have shown great promise for use in diagnostic and therapeutic applications, respectively. A challenge associated with translating 44Sc and 67Cu from research scale to long-term medical use is the difficulty in producing each of these radionuclides in large quantities. The production limitation is due to the low cross sections (the probability) of the nuclear reactions that create the purist supply of these isotopes. Since production routes using particle beams commonly used for medical isotopes (protons, neutrons, deuterons) do not result in sufficient cross sections, the proposed work aims to investigate employing heavy ion beam reactions. Heavy ion beams, such as 7Li, offer the potential to produce 67Cu and 44Ti (44Ti is the 44Sc parent) at higher cross sections. The proposed research will focus on the measurement of the cross sections for such reactions. Additionally, post irradiation radiochemistry will be performed so that the final purity of the radionuclides can be compared to the current production methods. Successful demonstration of higher production rates with comparable radionuclide purity will offer an additional production route to make these valuable medical isotopes.

研究医用同位素生产的替代核反应