Identification of Biological pathways regulated by circular RNAs

环状RNA调控的生物途径的鉴定

• 批准号: DP210101755
• 负责人: A/Prof Joseph Rosenbluh
• 金额: $ 35.5万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210101755
• 关键词: Identification; Biological; pathways; regulated; circular

Circular RNAs (circRNAs) are a, recently discovered molecule. circRNAs are highly abundant and expressed in a tissue and disease specific manner. Yet, currently the understanding of how circRNAs regulate biological processes is very poor. This project aims to use pooled shRNA libraries to screen a large panel of cell lines and systematically identify cellular activities that are regulated by circRNAs. The expected outcome of this study will be a catalogue of functionally active circRNAs. Over the past decades, the wealth of knowledge on the function of linear mRNAs has had a significant impact on medicine and agriculture. Similarly understanding how circRNAs regulate cellular activities may have an analogous impact on humans.

环状RNA(CircRNAs)是最近发现的一种分子。CircRNAs含量非常丰富，并以组织和疾病特有的方式表达。然而，目前对CircRNAs如何调控生物过程的了解很少。该项目旨在使用汇集的shRNA文库来筛选大量的细胞系，并系统地识别受CircRNAs调控的细胞活动。这项研究的预期结果将是一个具有功能活性的CircRNA目录。在过去的几十年里，关于线性mRNAs功能的丰富知识对医学和农业产生了重大影响。同样，了解CircRNA如何调节细胞活动也可能对人类产生类似的影响。