Emergency COVID-19 supplement for Atlanta Center for Microsystems Engineered Point-of-Care Technoloites (ACME POCT)

护理点（POC）诊断能力的出现使得能够在医生的办公室、救护车、家庭、现场或医院中进行快速和及时的临床评估，并且具有显著影响医疗保健提供的潜力。在心脏病学、肺病学/重症监护和血液学中，POC测试起着特别重要的作用，因为心脏和肺是最重要的器官之一，在重症疾病期间需要真实的时间诊断和快速管理，而血液中的病理变化与重症全身性疾病相关。显示出POC应用前景的一类新型医疗技术是微系统工程技术，即微芯片启用的设备，范围从基于微机电系统（MEMS）的传感器、微流体甚至基于智能手机的系统。基于微芯片的系统以其小尺寸和功耗要求而闻名，可提供对POC测试至关重要的便携性。此外，微系统将声音和运动转换为电信号的能力使这些技术成为感测肺部和心脏动态的理想设备，从而诊断和监测肺部和心脏疾病。此外，微系统工程已经带来了微流体领域，这是稳步发现应用于血液为基础的诊断，因此，血液学应用。为此，根据NHLBI的U 54 POCTRN指南，亚特兰大微系统工程POC技术中心的总体目标是（ACME POCT）是帮助和使来自全国各地的发明者能够开发基于微系统的POC技术，用于心脏，肺，血液和睡眠应用，这些应用超出了概念验证，以定义其特定的临床需求，进行临床验证，并完善他们的技术，目的是加快转化和临床采用的道路，并直接解决其中的障碍。ACME POCT独特地利用了亚特兰大埃默里大学医院和亚特兰大儿童医疗保健中心（全国最大的儿科医院系统之一）的全国顶级临床项目，以及格鲁吉亚理工学院（包括电子和纳米技术研究所（IEN））的国际知名微系统工程专业知识，以及其他独一无二的医疗设备原型设计，创新和试验台设施。ACME POCT PI独特地平衡了该中心的工程和临床方面，包括埃默里大学和格鲁吉亚理工学院的临床血液学家Wilbur Lam，医学博士，博士，在POC诊断开发和商业化方面具有专业知识的生物工程师，奥利弗Brand，博士，著名的微系统工程师和格鲁吉亚理工学院的IEN负责人，以及Greg Martin，医学博士，理学硕士，他是埃默里大学的临床肺病学家，也是亚特兰大NIH资助的CTSA临床研究的负责人。重要的是，ACME POCT的领导层在管理促进医疗器械开发的中心方面有着合作和跟踪记录的历史。

The advent of point-of-care (POC) diagnostic capabilities has enabled rapid and timely clinical evaluation in the physician's office, an ambulance, the home, the field, or in the hospital and has the potential to significantly impact health care delivery. In cardiology, pulmonology/critical care, and hematology, POC testing plays an especially significant role as the heart and lungs are among the most vital of organs necessitating real time diagnosis and rapid management during critical illnesses, while pathologic alternations in blood are associated with critical, systemic illness. One class of novel medical technologies that is showing promise for POC applications are microsystems-engineered technologies, that is, microchip-enabled devices ranging from microelectromechanical systems (MEMs)-based sensors, microfluidics, to even smartphone-based systems. Notable for their small size and power requirements, microchip-based systems provide the portability that is vital for POC testing. In addition, the capability of microsystems to convert sound and movement into electrical signals enable these technologies to be ideal devices to sense the dynamics of the lungs and heart and therefore to diagnose and monitor pulmonary and cardiac disorders. Moreover, microsystems engineering has brought forth the field of microfluidics, which is steadily finding applications for blood-based diagnostics, and therefore, hematologic applications. To that end, per the NHLBI's U54 POCTRN guidelines, the overall goal of the Atlanta Center for Microsystems Engineered POC Technologies (ACME POCT) is to assist and enable inventors from across the country who have developed microsystems-based POC technologies for cardiac, pulmonary, hematologic and sleep applications that are beyond proof-of-concept to define their specific clinical needs, conduct clinical validation, and refine their technology, with the objective of accelerating the path to translation and clinical adoption and directly addressing the barriers thereof. The ACME POCT uniquely leverages Atlanta's nationally top-ranked clinical programs at Emory University's hospitals and Children's Healthcare of Atlanta, one of the nation's largest pediatric hospital systems, as well the internationally acclaimed microsystems engineering expertise at Georgia Tech, which includes the Institute for Electronics and Nanotechnology (IEN), and other one-of-a-kind medical device prototyping, innovation, and testbed facilities. The ACME POCT PI's uniquely balance the engineering and clinical sides of the Center and comprise Wilbur Lam, MD, PhD, a clinical hematologist at Emory and Georgia Tech bioengineer with expertise in POC diagnostic development and commercialization, Oliver Brand, PhD, a renowned microsystems engineer and head of Georgia Tech's IEN, and Greg Martin, MD, MSc, a clinical pulmonologist at Emory and head of clinical research in Atlanta's NIH-funded CTSA. Importantly, the leadership of the ACME POCT has a history of collaboration and track record in managing Centers that have fostered medical device development.