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Synthetic Antibody Mimics as Antimalarial Agents

作为抗疟剂的合成抗体模拟物

基本信息

批准号：
10161881
负责人：
Mark Patrick Farrell
金额：
$ 13.43万
依托单位：
UNIVERSITY OF KANSAS LAWRENCE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2021-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10161881
关键词：
Address Administrator Animals Antimalarials Area Biological Biological Models Biological Sciences Biology Biomedical Research Centers of Research Excellence Chemicals Chemotherapy-Oncologic Procedure Communicable Diseases Communities Core Facility Development Environment Facility Accesses Faculty Funding Future Infectious Agent Infectious Diseases Research Infrastructure Institution Intervention Kansas Lead Mentors Mentorship Microbiology Modernization Molecular Organism Pathogenesis Pathway interactions Peer Review Pharmaceutical Chemistry Pharmacologic Substance Pharmacology Principal Investigator Process Proteomics Public Health Research Research Personnel Resistance Resources Science Scientist Series Techniques United States National Institutes of Health Universities Validation Virulence Factors Work antimicrobial distinguished professor drug discovery effective therapy experience high throughput screening human microbiota infectious disease treatment interest microbial mid-career faculty multidisciplinary novel pathogen professor programs public health relevance recruit synthetic antibodies tool

项目摘要

DESCRIPTION (provided by applicant): The development of new treatments of infectious disease is a preeminent challenge of biomedical science due to the continued expansion of organisms resistant to existing therapies, the reemergence of infectious agents once thought vanquished, and the spread of infectious diseases lacking effective treatments. The present proposal seeks to establish a Center for Biomedical Research Excellence with a multidisciplinary theme of Chemical Biology of Infectious Disease. Chemical biology entails the discovery of chemical entities able to modulate pathways related to infectious processes and can lead to the identification of novel targets for chemical intervention. The proposed Center will strengthen infrastructure and enable scientists and biomedical research in the State of Kansas and be led by University Distinguished Professor Jeffrey Aube, an experienced researcher and scientific administrator. It will address the following specific aims: (1) Provide a world-class environment, appropriately administered and staffed, to provide researchers access to key techniques relevant to the chemical biology of infectious disease. (2) Support and enable junior faculty to build successful research programs through active mentorship, access to appropriate resources, and funding of meritorious programs. (3) Enhance infectious disease research throughout the regional scientific community by the recruitment of outstanding junior faculty, establishment of seminar series and other opportunities for scientific enrichment, and by providing core facility access to all interested researchers.

描述（由申请人提供）：传染病新治疗方法的发展是生物医学科学的一个重大挑战，因为对现有治疗方法有抗药性的生物体不断扩大，曾经被认为已被征服的传染性病原体重新出现，以及缺乏有效治疗的传染病的传播。本提案旨在建立一个以传染病化学生物学为多学科主题的卓越生物医学研究中心。化学生物学需要发现能够调节与感染过程相关的途径的化学实体，并可能导致确定化学干预的新靶标。拟议的中心将