Assess and Adapt to the Impact of COVID-19 on CVD Self Management and Prevention Care in Adults Living with HIV (AAIM-High)
评估和适应 COVID-19 对成人 HIV 感染者 CVD 自我管理和预防护理的影响 (AAIM-High)
基本信息
- 批准号:10164926
- 负责人:
- 金额:$ 44.65万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-07-01 至 2021-07-31
- 项目状态:已结题
- 来源:
- 关键词:2019-nCoVAIDS/HIV problemAdherenceAdministrative SupplementAdoptionAdultAgeAgingBehaviorBlood PressureBlood Pressure MonitorsCOVID-19COVID-19 pandemicCardiovascular DiseasesCardiovascular systemCaringCholesterolClinicClinical TrialsCommon Data ElementCommunitiesCommunity Health AidesComputerized Medical RecordCoronavirusDataEatingEducationEffectivenessEnrollmentFamily memberFrequenciesFriendsFundingGoalsHIVHIV riskHealthHealth PersonnelHealth systemHome Blood Pressure MonitoringHome environmentHumanHybridsHypertensionIndividualInstitutional Review BoardsInterventionLonelinessMaintenanceMeasuresMedical Care TeamMental DepressionMethodsModelingMorbidity - disease rateNursesOutcomeParentsParticipantPatientsPersonsPharmaceutical PreparationsPhysical activityPredispositionPreventionPreventive InterventionProceduresProtocols documentationPublic HealthRandomizedRandomized Controlled TrialsRemote ConsultationResourcesRiskRisk FactorsSelf ManagementSocial DistanceSocial ImpactsSocial InteractionSocial isolationSocial supportSourceSpecialistStressSupport GroupsTechnologyTelephoneTestingUnited States National Institutes of HealthUniversity HospitalsVideoconferencesVulnerable Populationsantiretroviral therapyarmbaseblood pressure regulationcardiovascular disorder preventioncardiovascular disorder riskcardiovascular risk factorcare coordinationcholesterol controlcigarette smokingcombatcoronavirus diseasedata formatdesigneffectiveness clinical trialeligible participantethnic diversitygood diethealth care deliveryhigh riskimprovedinattentioninstrumentloved onesmedical specialtiesmeetingsmembermortalitynursing interventionpandemic diseaseprevention serviceracial diversityresponsesexsocialsocial stigmasupport toolstherapy designvirtual
项目摘要
Social distancing in the context of the SARS-CoV-2 coronavirus and COVID-19 disease pandemic may amplify
isolation and loneliness due to the requirement to limit in-person interactions with loved ones, friends,
community members, healthcare providers, etc. Social isolation increases susceptibility to illness, stress,
hypertension, depression, and mortality and decreases engagement in self-management and physical
activity. People living with HIV (PLWH) are at increased risk for cardiovascular disease (CVD) and are
particularly vulnerable to the stress and social isolation caused by the public health measures to combat
COVID-19. Using mixed-methods and a human-centered design approach, we have developed and are
currently testing in a randomized controlled trial a nurse-led intervention to EXtend the HIV/AIDS
TReatment cAscade for CVD prevention (EXTRA-CVD). Racially and ethnically diverse participants on
suppressive antiretroviral therapy (n=300 total; 64 enrolled to date) with high BP AND high cholesterol from 3
HIV-specialty clinics [University Hospitals, MetroHealth (both Cleveland, OH) and Duke Health (Durham, NC)]
are randomized 1:1 to intervention vs. education control. In response to NOT-OD-20-757, we propose this
administrative supplement to leverage the EXTRA-CVD platform to Assess and Adapt to the Impact of
COVID-19 on CVD Self-Management and Prevention Care in Adults Living with HIV (AAIM-High). The
proposed activities are IRB approved and ready to begin immediately if funded. In a formative Aim 1, we
will assess the impact of COVID-19 related social distancing on HIV and CVD self-management
behaviors among participants in EXTRA-CVD using well-validated instruments, NIH common data elements
and a sequential mixed-methods design. In Aim 2, we will conduct a hybrid type 3 implementation study to
evaluate the implementation of a virtually enhanced EXTRA-CVD intervention to improve BP control in
PLWH. Using a human-centered design approach, we will convene our EXTRA-CVD stakeholder Design
Team, to refine virtual enhancements to the intervention, such as virtual adherence support groups,
cardiovascular prevention specialist remote consultation, and community health worker technology
coaches. We will enroll adult PLWH participants (n=75) on suppressive ART with high BP whom are otherwise
ineligible for the parent trial because they do not also have high cholesterol or because they are unwilling or
unable to participate in the in-person trial. Thus, this supplemental study arm will not poach potentially
eligible participants from the parent trial. Implementation outcomes based on a RE-AIM framework will be
compared to parent trial participants: reach (% agreeing to participate), effectiveness (change in home
systolic BP), adoption (frequency of home BP use), implementation (qualitative assessment of
feasibility/acceptability), and maintenance (qualitative). This supplement will increase the impact and
scalability of the EXTRA-CVD study without compromising the integrity or feasibility of the parent trial.
在SARS-CoV-2冠状病毒和COVID-19疾病大流行的背景下,社交距离可能会扩大
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Hayden B Bosworth其他文献
Implementing guideline-directed medical therapy: Stakeholder-identified barriers and facilitators
实施指南指导的医疗治疗:利益相关者所确定的障碍与促进因素
- DOI:
10.1016/j.ahj.2024.11.011 - 发表时间:
2025-03-01 - 期刊:
- 影响因子:3.500
- 作者:
Josephine Harrington;Monica Leyva;Vishal N Rao;Megan Oakes;Nkiru Osude;Hayden B Bosworth;Neha J Pagidipati - 通讯作者:
Neha J Pagidipati
CMAR_A_191040 6793..6802
CMAR_A_191040 6793..6802
- DOI:
- 发表时间:
2019 - 期刊:
- 影响因子:0
- 作者:
Leah L Zullig;Valerie A Smith;Jennifer H Lindquist;C. D. Williams;Morris Weinberger;Dawn Provenzale;G. Jackson;Michael J Kelley;Susanne Danus;Hayden B Bosworth - 通讯作者:
Hayden B Bosworth
Hayden B Bosworth的其他文献
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{{ truncateString('Hayden B Bosworth', 18)}}的其他基金
A nurse-led intervention to extend the Veteran HIV treatment cascade for cardiovascular disease prevention (V-EXTRA-CVD)
护士主导的干预措施,旨在扩大退伍军人艾滋病毒治疗级联以预防心血管疾病 (V-EXTRA-CVD)
- 批准号:
10242705 - 财政年份:2020
- 资助金额:
$ 44.65万 - 项目类别:
A nurse-led intervention to extend the Veteran HIV treatment cascade for cardiovascular disease prevention (V-EXTRA-CVD)
护士主导的干预措施,旨在扩大退伍军人艾滋病毒治疗级联以预防心血管疾病 (V-EXTRA-CVD)
- 批准号:
10492455 - 财政年份:2020
- 资助金额:
$ 44.65万 - 项目类别:
A nurse-led intervention to extend the Veteran HIV treatment cascade for cardiovascular disease prevention (V-EXTRA-CVD)
护士主导的干预措施,旨在扩大退伍军人艾滋病毒治疗级联以预防心血管疾病 (V-EXTRA-CVD)
- 批准号:
10064162 - 财政年份:2020
- 资助金额:
$ 44.65万 - 项目类别:
A nurse-led intervention to extend the Veteran HIV treatment cascade for cardiovascular disease prevention (V-EXTRA-CVD)
护士主导的干预措施,旨在扩大退伍军人艾滋病毒治疗级联以预防心血管疾病 (V-EXTRA-CVD)
- 批准号:
10759367 - 财政年份:2020
- 资助金额:
$ 44.65万 - 项目类别:
A nurse-led intervention to extend the HIV treatment cascade for cardiovascular disease prevention (EXTRA-CVD)
由护士主导的干预措施,旨在扩大艾滋病毒治疗级联以预防心血管疾病 (EXTRA-CVD)
- 批准号:
10470074 - 财政年份:2018
- 资助金额:
$ 44.65万 - 项目类别:
A nurse-led intervention to extend the HIV treatment cascade for cardiovascular disease prevention (EXTRA-CVD)
由护士主导的干预措施,旨在扩大艾滋病毒治疗级联以预防心血管疾病 (EXTRA-CVD)
- 批准号:
9978088 - 财政年份:2018
- 资助金额:
$ 44.65万 - 项目类别:
A nurse-led intervention to extend the HIV treatment cascade for cardiovascular disease prevention (EXTRA-CVD)
由护士主导的干预措施,旨在扩大艾滋病毒治疗级联以预防心血管疾病 (EXTRA-CVD)
- 批准号:
9763155 - 财政年份:2018
- 资助金额:
$ 44.65万 - 项目类别:














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