R25EB023856 Supplement LeeYM P0546225

项目摘要 加州大学旧金山分校外科系，与生物工程和 治疗科学，建议在临床上建立跨学科R25研究教育计划 以及为外科住院医生翻译的“生物设备创新”。外科医生拥有丰富的知识 解剖学，非常熟悉他们患者的需求和当前技术的局限性，以及 具有较强的解决问题的能力，能够不断地即兴提出解决问题的方法 手术室。然而，NIH资助的外科医生和研究人员的水平不断下降，使得结构性 改变外科培训方案并引入创新方法，以便更多地参与 研究中的外科医生。设备创新越来越被认为是一个研究领域， 外科医生可以做出重大的创造性贡献，深刻地影响患者的护理。专为外科设计 对作为临床医生创新者的职业感兴趣的居民，拟议的计划将提供实践研究 住院医师在两个专注的研究年中与杰出教员一起工作的经验 来自外科、生物工程、放射学和其他相关临床学科的创新者开发和 为未得到满足的临床需求翻译基于设备的新型解决方案。在此过程中，参与者将制定 必需的生物工程研究技能、医疗产品开发流程知识和导师 帮助他们开始自己的研究事业，成功地竞争拨款，以及 作为独立的外科医生和科学家，成功地从事设备创新。领导团队有一个多- 一年的合作历史，将生物工程的进展转化为创新的新治疗范例 以及通过FDA赞助的加州大学旧金山分校儿科项目等成功项目在临床护理方面的突破 设备联盟和加州大学旧金山分校的外科创新倡议。该计划的许多关键要素包括 已经到位，包括与加州大学洛杉矶分校-加州大学伯克利分校生物工程联合毕业生小组的联系，UCB- 加州大学旧金山分校转化医学硕士项目，加州大学旧金山分校-斯坦福大学监管卓越中心 科学与创新(CERSI)，以及支持加州大学旧金山分校设备创新的强大基础设施。培训 该计划由一支杰出的导师团队支持，其中包括享誉国际的教师 设备创新成果丰硕。

Project Summary The UC San Francisco Department of Surgery, in collaboration with the Department of Bioengineering and Therapeutic Sciences, proposes to establish an interdisciplinary R25 research education program in clinical and translational “Biodevice Innovation” for surgical residents. Surgeons possess extensive knowledge of anatomy, are intimately familiar with the needs of their patients and the limitations of current technology, and possess strong problem solving abilities developed out of the necessity to constantly improvise solutions in the operating room. However, the declining levels of NIH-funded surgeon-investigators necessitates structural changes in surgical training programs and the introduction of innovative approaches in order to engage more surgeons in research. Device innovation is becoming increasingly recognized as a research area in which surgeons can make significant creative contributions that profoundly impact patient care. Designed for surgical residents interested in careers as clinician-innovators, the proposed program would provide hands-on research experiences for residents during their two dedicated research years to work alongside prominent faculty innovators from Surgery, Bioengineering, Radiology, and other relevant clinical disciplines to develop and translate novel device-based solutions for unmet clinical needs. In the process, participants will develop the requisite bioengineering research skills, knowledge of the medical product development process, and mentor relationships to help launch their own research careers, successfully compete for grant funding, and successfully engage in device innovation as independent surgeon-scientists. The leadership team has a multi- year history of collaboration translating advances in bioengineering into innovative new treatment paradigms and breakthroughs in clinical care through successful programs such as the FDA-sponsored UCSF Pediatric Device Consortium and UCSF's Surgical Innovations Initiative. Many of the key elements of the program are already in place, including ties to the UCSF-UC Berkeley Joint Graduate Group in Bioengineering, the UCB- UCSF Master of Translational Medicine Program, the UCSF-Stanford Center of Excellence in Regulatory Science & Innovation (CERSI), and a robust infrastructure supporting device innovation at UCSF. The training program is supported by an outstanding mentorship team including faculty internationally renowned for their achievements in device innovation.