BoostOne

升压一

• 批准号: 10158895
• 负责人: Salil Patel
• 金额: $ 24.56万
• 依托单位: NXTECH INC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10158895
• 关键词: Acute; Address; Adherence; Affect; Animal Model; Attention; Cellular Phone; Client; Clinic; Clinical; Cognitive; Computer software; Counseling; Cues; Custom; Data; Decision Making; Disease; Drug usage; Educational Intervention; Engineering; Event; Executive Dysfunction; Exercise; Face; Feasibility Studies; Formularies; Foundations; Goals; Government; Hyperactivity; Impairment; Impulsivity; Incentives; Individual; Insurance Carriers; Intervention; Learning; Letters; Licensing; Measurement; Measures; Medical; Memory; Modeling; Motivation; Neurobiology; Outcome; Outcome Measure; Outpatients; Participant; Pathway interactions; Patients; Periodicity; Persons; Pharmaceutical Preparations; Phase; Population; Prevention strategy; Process; Psychometrics; Public Health; Recovery; Relapse; Research; Resources; Sales; Self Perception; Self-control as a personality trait; Series; Short-Term Memory; Signal Transduction; Small Business Innovation Research Grant; Social Environment; Societies; System; Technology; Test Result; Testing; Therapeutic; Time; Time Perception; Traction; Training; Treatment Efficacy; Treatment Protocols; Treatment outcome; Urine; Validation; Vision; Visit; active method; base; cloud software; cost; craving; design; digital; directed attention; disorder later incidence prevention; distraction; efficacy evaluation; executive function; experience; improved; innovation; mindfulness; neurobehavioral; non-opioid analgesic; novel; opioid therapy; opioid use disorder; opioid user; patient engagement; peer support; primary outcome; psychologic; quality assurance; relating to nervous system; response; satisfaction; smartphone Application; successful intervention; tool; uptake; usability

PROJECT SUMMARY Individuals with opioid user disorder (OUD) face both short-term and long-horizon challenges to healthy and productive decision-making. Recovery, particularly in the setting of MAT (but also more generally), is deeply affected by phasic/psychological cravings and impaired long-horizon decision-making. Current cravings- avoidance tools suffer from limited usability and restricted utility in common environmental/social contexts. In addition, the majority of introspective or self-control improvement strategies (mindfulness, CBT) are unsuited for uptake during moments of vulnerability, while clinical counseling or peer support suffer from scale/access limitations. In response, we propose a field-deployable (mobile smartphone), automated intervention for acute cravings in OUD which simultaneously addresses neurobiological drivers of long-term impulsive decision- making. The innovation (“BoostONE”) comprises a system for just-in-time cravings management (Boost-C) and impulsivity mitigation (Boost-I) and includes a framework for psychometric measurement of executive function for outcomes tracking. Predicted effects of usage by individuals in MAT will be evaluated in a feasibility study of the validated package. We anticipate this Phase I SBIR will provide the foundation for deployment of BoostONE in active treatment settings and for broader extensions of the underlying technology framework.

项目摘要 阿片类药物使用者障碍（OUD）患者面临着短期和长期的健康挑战， 富有成效的决策。恢复，特别是在MAT的设置（但也更普遍），是深刻的 受阶段性/心理渴望和长期决策受损的影响。当前的渴望- 回避工具在常见的环境/社会背景下受到有限的可用性和有限的效用的影响。在 此外，大多数内省或自我控制改善策略（正念，CBT）不适合 在脆弱的时刻吸收，而临床咨询或同行支持遭受规模/访问 局限性。作为回应，我们提出了一个现场部署（移动的智能手机），自动干预急性 OUD中的渴望同时解决了长期冲动决策的神经生物学驱动因素- 制作。创新（“BoostONE”）包括一个即时渴望管理系统（Boost-C）， 冲动缓解（Boost-I），包括执行功能的心理测量框架， 成果跟踪。在MAT中个人使用的预测效果将在一项可行性研究中进行评估， 验证包。我们预计，第一阶段SBIR将为部署BoostONE提供基础， 积极的治疗环境和更广泛的扩展基础技术框架。