BoostOne

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PROJECT SUMMARY Individuals with opioid user disorder (OUD) face both short-term and long-horizon challenges to healthy and productive decision-making. Recovery, particularly in the setting of MAT (but also more generally), is deeply affected by phasic/psychological cravings and impaired long-horizon decision-making. Current cravings- avoidance tools suffer from limited usability and restricted utility in common environmental/social contexts. In addition, the majority of introspective or self-control improvement strategies (mindfulness, CBT) are unsuited for uptake during moments of vulnerability, while clinical counseling or peer support suffer from scale/access limitations. In response, we propose a field-deployable (mobile smartphone), automated intervention for acute cravings in OUD which simultaneously addresses neurobiological drivers of long-term impulsive decision- making. The innovation (“BoostONE”) comprises a system for just-in-time cravings management (Boost-C) and impulsivity mitigation (Boost-I) and includes a framework for psychometric measurement of executive function for outcomes tracking. Predicted effects of usage by individuals in MAT will be evaluated in a feasibility study of the validated package. We anticipate this Phase I SBIR will provide the foundation for deployment of BoostONE in active treatment settings and for broader extensions of the underlying technology framework.