Mechanisms and Platforms for Acoustomicrofluidic Intracellular Delivery

声微流控细胞内输送的机制和平台

• 批准号: DP210101720
• 负责人: Prof Leslie Yeo
• 金额: $ 31.65万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-03-31 至 2024-03-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210101720
• 关键词: Mechanisms; Platforms; Acoustomicrofluidic; Intracellular; Delivery

This project aims to advance a novel platform to facilitate faster and more effective molecular transport into cells as a means for enhancing cell engineering. Besides elucidating the fundamental physicochemical and biological mechanisms underpinning this new method of intracellular transport through a combination of theoretical modelling and advanced imaging and neutron diffraction, the project aims to show the scalability of the technology for high throughput processing to handle the large cell numbers typically required for doses to be effective in practice. Given recent breakthroughs in cell therapies, it is expected that translation of the technology in the longer term will improve treatments for cancer and other infectious diseases.

该项目旨在推进一个新的平台，以促进更快、更有效的分子转运到细胞中，作为增强细胞工程的一种手段。除了通过理论建模、先进成像和中子衍射相结合，阐明支撑这种细胞内运输新方法的基本物理化学和生物机制外，该项目还旨在展示该技术的可扩展性，用于高通量处理，以处理实际中剂量有效所需的大细胞数量。鉴于最近在细胞疗法方面取得的突破，预计从长远来看，这项技术的转化将改善癌症和其他传染病的治疗。