Training in Molecular and Systems Toxicology

摘要 拟议的科罗拉多大学安舒茨医学院T32级分子和 系统毒理学(MST)提供以培训为中心的多学科研究指导计划 系统毒理学包括基因组学/表观遗传学、蛋白质组学、代谢组学以及分子毒理学 了解潜在毒性机制的方法。拟议的T32培训计划将是 在多机构毒理学和药学研究生课程下提供住房，这些课程是 总部设在斯卡格斯药学院药学系内，但包括 安舒茨医学院和公共卫生学院的教员，还包括 来自国家犹太人健康中心的教员。建议的MST培训计划要求2名博士后 2年支持职位/年(第3年和第4年，共8名博士前实习生，为期5年)。这个 拟议的科罗拉多大学安舒茨医学院MST培训计划将由16人支持 专注于系统毒理学研究的学院，并被列为T32应用程序的导师。 该培训计划的主要目标和责任是将博士后培养成 独立和成功的环境健康科学家，具有系统毒理学方面的专业知识。这一目标将 通过利用：1)国际公认的、资金充足的系统毒理学研究导师；2) 加州大学安舒茨分校杰出的机构支持；3)有针对性的教学方法；4) 在研究、赠款编写和职业发展方面负责任的行为培训；5)继续在 招聘和加强多样性；6)继续让学生参与研究、教育和职业生涯 通过各种项目进行开发；7)系统毒理学相关课程的持续开发 和经验；8)评估指标，以持续改进加州大学安舒茨MST培训计划。 最终，我们希望我们的受训人员发展成为拥有以下知识和技能的独立科学家 利用尖端的“组学”和“大数据”应对毒理学和环境健康领域的挑战 接近了。

Abstract The proposed University of Colorado Anschutz Medical Campus T32 training program in Molecular and Systems Toxicology (MST) provides a multi-disciplinary research mentorship program centered around training in systems toxicology including genomics/epigenetics, proteomics, and metabolomics as well as molecular approaches to understand underlying mechanisms of toxicity. The proposed T32 training program will be housed under the multi-institutional Toxicology and Pharmaceutical Sciences graduate programs which are based within the Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, but which includes faculty from the Schools of Medicine and Public Health on the Anschutz Medical Campus and also includes faculty from National Jewish Health. The proposed MST training program is requesting 2 predoctoral positions/year for 2 years of support (in years 3 & 4 for a total of 8 predoctoral trainees over 5 years). The proposed University of Colorado Anschutz Medical Campus MST training program will be supported by 16 faculty which are focused on systems toxicology research and are listed as mentors on this T32 application. This training program has the primary goal and responsibility of developing predoctoral students into independent and successful environmental health scientists with expertise in systems toxicology. This goal will be achieved by utilizing: 1) internationally recognized, well-funded research mentors in systems toxicology; 2) outstanding institutional support from the UC Anschutz campus; 3) targeted didactic learning approaches; 4) training in responsible conduct in research, grant writing and career development; 5) continued excellence in recruitment and enhancement of diversity; 6) continued student engagement in research, education and career development through various programs; 7) continual development of systems toxicology related coursework and experiences; 8) evaluation metrics to continually improve the UC Anschutz MST training program. Ultimately, we expect our trainees to develop into independent scientists with the knowledge and skills to address challenges in toxicology and environmental health using cutting edge `omics' and `big data' approaches.