Training in Molecular and Systems Toxicology

分子和系统毒理学培训

• 批准号: 10415885
• 负责人: Jared Michael Brown
• 金额: $ 13.68万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415885
• 关键词: Molecular; System; Toxicology; Training

Abstract The proposed University of Colorado Anschutz Medical Campus T32 training program in Molecular and Systems Toxicology (MST) provides a multi-disciplinary research mentorship program centered around training in systems toxicology including genomics/epigenetics, proteomics, and metabolomics as well as molecular approaches to understand underlying mechanisms of toxicity. The proposed T32 training program will be housed under the multi-institutional Toxicology and Pharmaceutical Sciences graduate programs which are based within the Department of Pharmaceutical Sciences, Skaggs School of Pharmacy, but which includes faculty from the Schools of Medicine and Public Health on the Anschutz Medical Campus and also includes faculty from National Jewish Health. The proposed MST training program is requesting 2 predoctoral positions/year for 2 years of support (in years 3 & 4 for a total of 8 predoctoral trainees over 5 years). The proposed University of Colorado Anschutz Medical Campus MST training program will be supported by 16 faculty which are focused on systems toxicology research and are listed as mentors on this T32 application. This training program has the primary goal and responsibility of developing predoctoral students into independent and successful environmental health scientists with expertise in systems toxicology. This goal will be achieved by utilizing: 1) internationally recognized, well-funded research mentors in systems toxicology; 2) outstanding institutional support from the UC Anschutz campus; 3) targeted didactic learning approaches; 4) training in responsible conduct in research, grant writing and career development; 5) continued excellence in recruitment and enhancement of diversity; 6) continued student engagement in research, education and career development through various programs; 7) continual development of systems toxicology related coursework and experiences; 8) evaluation metrics to continually improve the UC Anschutz MST training program. Ultimately, we expect our trainees to develop into independent scientists with the knowledge and skills to address challenges in toxicology and environmental health using cutting edge `omics' and `big data' approaches.

抽象的 拟议的科罗拉多大学Anschutz大学医学校园T32分子和 系统毒理学（MST）提供了一个围绕培训的多学科研究指导计划 在系统毒理学中，包括基因组/表观遗传学，蛋白质组学和代谢组学以及分子 了解毒性的潜在机制的方法。拟议的T32培训计划将是 在多机构的毒理学和药学科学研究生课程下安置 基于制药科学系，斯卡格斯药学院，但其中包括 Anschutz医疗校园的医学和公共卫生学院的教职员工，还包括 来自国家犹太人健康的教师。拟议的MST培训计划要求2个 两年支持的职位/年（在3年级和4年中，共5年，总共有8个占主导地位的学员）。这 拟议的科罗拉多大学Anschutz大学医学校园MST培训计划将得到16 专注于系统毒理学研究的教师被列为T32应用程序的导师。 该培训计划的主要目标和责任是将前学生发展成 具有系统毒理学专业知识的独立和成功的环境健康科学家。这个目标将 可以通过使用以下方式来实现：1）系统毒理学中的国际认可，资金充足的研究导师； 2） UC Anschutz校园的杰出机构支持； 3）有针对性的教学学习方法； 4） 在研究，授予写作和职业发展方面负责任的培训； 5）持续卓越 招募和增强多样性； 6）继续学生参与研究，教育和职业 通过各种计划开发； 7）系统毒理学相关课程的持续发展 和经验； 8）评估指标以不断改进UC Anschutz MST培训计划。 最终，我们希望我们的学员能够发展成具有知识和技能的独立科学家 使用最先进的“ Omics”和“大数据”解决毒理学和环境健康方面的挑战 方法。