Unified Program for Therapeutics in Children (UPTiC)

儿童治疗统一计划 (UPTiC)

• 批准号: 10159122
• 负责人: Ian J Davis
• 金额: $ 50.71万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10159122
• 关键词: Child; Therapeutic; programs

The development pipeline for prophylactics and therapeutics that target pediatric diseases is sparse compared to that of adults. A gap in the understanding of pediatric physician-scientists regarding how to span this translational divide compromises the development of promising therapies. The primary goal of this Unified Program for Therapeutics in Children (UPTiC) is to train young pediatric physician-scientists with strong academic potential to lead the development of novel therapeutics and prophylactics for children and be thought- leaders in the field of pediatric drug development. The program will train subspecialty pediatric fellows in 3 tracks that span the full pipeline of clinical development: 1) discovery-based research (preclinical/translational pediatric drug development), 2) clinical pediatric trials, and 3) outcomes/real world evidence. The program will cover three major training aims, including: 1) individualized didactic and degree-oriented course work in pediatric drug development, 2) mentored training in preclinical, clinical trials, and outcomes research, and 3) grant-writing training and mock review. The training of these pediatric research fellows will be through a combined effort bringing together the Duke University School of Medicine, including the Department of Pediatrics and the Duke Clinical Research Institute, and the University of North Carolina at Chapel Hill, including the Department of Pediatrics, School of Pharmacy, and School of Public Health. UPTiC will be led by a team of multi- university, multi-disciplinary, well-funded, and experienced faculty members, including 39 full-time Duke and UNC faculty members in Pediatrics and other basic, translational, and clinical science departments. This application requests support for six postdoctoral pediatric trainees (three new fellows per year, 2 years of support each). Trainees will be nationally recruited through established pediatric clinical trials networks led by the Duke Clinical Research Institute and Duke/UNC pediatric fellowship program directors and subsequently drawn from the pool of pediatric fellows at Duke and UNC. Individuals appointed to the training program will be named Katz- Denny Fellows. The training will center on research ongoing in the various faculty members' research groups across the Duke Medical Center and the University of North Carolina and a joint didactic program focusing on the therapeutic development pipeline for children. Upon completion of this training program, these pediatrician- scientists will be capable of not only leading translational and clinical pediatric-focused therapeutic development research, but also mentoring the next generation of pediatricians in the fundamentals of pediatric clinically- oriented research. Fulfillment of the program's objective would directly or indirectly address two imperatives: 1) the need for more full-time academic pediatric physician-researchers and mentors in medical schools throughout the country and 2) the unmet need for innovations and clinical translation of novel pediatric prevention and treatment strategies to improve the health of the youngest and most vulnerable members of our society.

相比之下 对成年人的。在理解小儿医师科学家如何跨越此事的差距 翻译划分损害了有前途的疗法的发展。这个统一的主要目标 儿童治疗计划（UPTIT）是培训年轻的儿科医师科学家 领导新的治疗学和预防药物的学术潜力，并被思考 - 小儿药物开发领域的领导者。该计划将在三首曲目中训练亚专科小儿研究员 跨越临床发展的完整管道：1）基于发现的研究（临床前/翻译 小儿药物开发），2）临床小儿试验和3）结果/现实世界证据。这 计划将涵盖三个主要的培训目标，包括：1）个性化的教学课程和以学位为导向的课程 小儿药物开发的工作，2）临床前，临床试验和结果研究的指导培训， 3）授予写作培训和模拟审查。这些小儿研究研究员的培训将是通过 将杜克大学医学院（包括儿科系）汇集在一起​​的共同努力 以及杜克临床研究所以及北卡罗来纳大学教堂山的大学，包括 儿科，药学院和公共卫生学院。 UPTIC将由一个多人团队领导 大学，多学科，资金丰富且经验丰富的教职员工，包括39名专职公爵和 UNC的儿科以及其他基本，转化和临床科学部门的教师。这 申请请求支持六名博士后小儿学员（每年三名新研究员，2年的支持 每个）。学员将通过由公爵领导的既定儿科临床试验网络招募全国招募 临床研究所和杜克/UNC儿科奖学金计划主管，随后从 杜克和UNC的小儿研究员池。任命为培训计划的个人将被任命为Katz- 丹尼家伙。该培训将在各个教师研究小组中正在进行的研究中心 在杜克大学医学中心和北卡罗来纳大学以及一个关注的联合教学计划 儿童的治疗发展管道。完成该培训计划后，这些儿科医生 - 科学家将不仅能够领导转化和临床儿科的治疗发展 研究，但也指导下一代儿科医生在儿科临床的基本面 定向研究。实现该计划的目标将直接或间接解决两个要塞：1） 需要更多的全职学术儿科医师研究者和医学院的导师 国家和2）未满足的创新需求和新型儿科预防和临床翻译 改善我们社会中最年轻，最脆弱的成员的健康的治疗策略。