Pulmonary Hypertension: State of the Art and Therapeutic Opportunities

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ABSTRACT Support is requested for a Keystone Symposia conference entitled Pulmonary Hypertension: State of the Art and Therapeutic Opportunities, organized by Drs. Marlene Rabinovitch and Kurt Stenmark. The conference will be held in Santa Fe, New Mexico from June 25 - 28, 2023. Pulmonary arterial hypertension is a progressive condition in which narrowing and obliteration of blood vessels results in elevated resistance to flow that culminates in heart failure. Current approved therapies improve survival and quality of life but new research approaches that tackle the complexities of pulmonary hypertension will allow us to identify, develop and pursue new agents that reverse disease. Therefore, this conference is designed to showcase the scientific advances in six areas that impact vascular and immune cell function: i) mitochondrial dynamics (ii) epigenomics and integrated omics (iii) aging and sex determinants (iv) genetics and data science (v) bioengineering and regeneration and (vi) inflammation. The conference program will cover the future of gene editing in pulmonary hypertension and heart failure. Speakers were invited with expertise in the above areas of interest, along with those who work on related aspects of pulmonary hypertension, in order to engage both seasoned and young investigators in a way that will catalyze innovative scientific approaches. Additionally, speakers will be challenged to relate their research to others in the field, to establish relationships and bridge gaps that will identify therapeutic possibilities beyond targeting one pathway or molecule. The program will also cover the pitfalls of current animal models and culture systems, in light of the complexities of the disease. There are also two workshops being planned. The first will highlight novel imaging technology in the field. The second is designed around the process of moving basic discovery to the patient. Finally, this conference will be held jointly with the Keystone Symposia meeting on Heart Failure. Attendees will share joint sessions, workshops, poster sessions, and mealtimes.