Consequences of Persistent Immune Activation among ART-treated Women with HIV

接受抗逆转录病毒治疗的艾滋病毒女性持续免疫激活的后果

• 批准号: 10161223
• 负责人: Markella V. Zanni
• 金额: $ 18.16万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10161223
• 关键词: Affect; Ancillary Study; Attention; Award; Biological; Biomedical Research; Biometry; Blood Vessels; Brain; CD8-Positive T-Lymphocytes; Cardiology; Cardiometabolic Disease; Cardiovascular system; Center for Translational Science Activities; Chronic; Clinical; Clinical Investigator; Communities; Complement; Consultations; Coronary; Dendritic Cells; Discipline; Disease; Dreams; Educational workshop; Endocrine; Endocrinology; Enrollment; Environment; Epidemiology; Epigenetic Process; Event; Exhibits; Functional disorder; Funding; General Hospitals; Generations; Genes; Goals; HIV; HIV-1; Heart; Hormonal; Immune; Immune response; Immunology; Inflammation; Interferon-alpha; Interferons; Kidney; Kidney Diseases; Lead; Leadership; Learning; Letters; Liver diseases; Lung; Massachusetts; Medicine; Mentors; Mentorship; Metabolism; Microvascular Dysfunction; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Neurocognitive; Organ; Outcome; Participant; Pathology; Patients; Pattern; Physiology; Public Health; Research; Research Institute; Research Personnel; Research Project Grants; Research Training; Risk; Risk Reduction; SARS-CoV-2 infection; Services; Sex Differences; T-Cell Activation; TLR7 gene; Testing; Time; Training; United States National Institutes of Health; Up-Regulation; Viral; Viremia; Virus; Woman; Women' s Health; Work; antiretroviral therapy; cardiovascular disorder risk; career; career development; catalyst; comorbidity; coronavirus disease; cytokine release syndrome; experience; faculty mentor; frailty; healthspan; immune activation; immunoregulation; insight; medical schools; men; mid-career faculty; patient oriented research; prevent; programs; randomized trial; reproductive senescence; research facility; response; sex; skills; success

7. Project Summary The NIH Midcareer Investigator Award in Patient-Oriented Research (POR) (K24) will enable me to advance research on consequences of persistent immune activation among ART-treated women with HIV (WWH) while developing my mentoring leadership skills and providing research mentorship to a diverse, interdisciplinary group of clinical investigators. My overall career goals are to continue to lead a robust research program with a newly expanded scope: investigating not only how persistent systemic immune activation among ART-treated WWH influences cardiometabolic disease, but also how this phenomenon influences diverse end-organ comorbidities - including end-organ disease incurred in the context of superimposed SARS-CoV-2 infection. As an Associate Professor at Harvard Medical School (HMS) and the Director of Women’s Health Research in Massachusetts General Hospital (MGH) Metabolism Unit, I lead NIH R01-funded projects which will serve as an outstanding platform for mentoring. The collaborative research environment at MGH/HMS supports my work in this interdisciplinary field, permitting me to synthesize insights from outstanding colleagues expert in HIV medicine, immunology, cardiology, endocrinology, and women’s health. Facilities, curricular offerings, and consultative services sponsored by the Mass General Research Institute and the Harvard Catalyst Clinical Translational Science Center contribute to the success of collaborative research. The career development aims of this proposal are to pursue advanced didactic training in immunology and biostatistics, as well as advanced didactic training in mentoring leadership. These efforts will help me expand my research program and build on my longstanding commitment to mentoring - a commitment reflected in •successful 1:1 mentoring of trainees •contributions to MGH/HMS POR- training efforts •Co-Direction of the MGH Endocrine Division Faculty Mentoring Initiative •Co- Sponsorship of the Mentoring the Mentors Workshop at HMS and •receipt of formal recognition for excellence in mentoring. The primary mentoring aim of this proposal is to nurture and support the career development of a diverse, interdisciplinary group of clinical investigators, all committed to POR relevant to the health of WWH. I also aspire to promote a culture of supportive, inclusive mentoring through leadership in mentoring programming. The K24 award will offer me protected time to achieve the aforementioned goals. MGH leadership has pledged to protect my time so as to allow me to focus on POR and POR mentoring. Support from mentors has helped me follow my dream of becoming an independent clinical investigator. Through this award, I seek to support the career development of a new generation of clinical investigators who will catalyze ground-breaking advances in biomedical research -- all for the benefit of patients.

7.项目总结 NIH以患者为中心的研究(POR)职业中期研究员奖(K24)将使我能够 抗逆转录病毒治疗妇女慢性粒细胞白血病持续免疫激活后果的研究进展 HIV(WWH)，同时发展我的指导领导技能，并为 不同的、跨学科的临床研究人员小组。我整个职业生涯的目标是继续领导 具有新扩展范围的强有力的研究计划：不仅调查如何持久 经ART治疗的WWH患者的系统免疫激活影响心脏代谢性疾病，但也 这种现象如何影响各种终末器官合并症--包括终末器官疾病 在SARS-CoV-2重叠感染的背景下发生的。作为哈佛大学的副教授 马萨诸塞州医学院(HMS)和妇女健康研究主任 医院(MGH)新陈代谢部门，我领导的NIH R01资助的项目将成为杰出的 指导的平台。MGH/HMS的协作研究环境支持我在这方面的工作 跨学科领域，使我能够综合来自艾滋病专家的杰出同事的见解 医学、免疫学、心脏病学、内分泌学和妇女健康。设施、课程设置、 和咨询服务，由大众综合研究所和哈佛大学促进会赞助 临床转化科学中心为合作研究的成功做出了贡献。职业生涯 这项建议的发展目标是在免疫学和 生物统计学，以及指导领导力的高级教学培训。这些努力将帮助我 扩大我的研究计划，并在我长期致力于指导的基础上-a 承诺体现在·对学员的成功1：1指导·对MGH/HMS POR的贡献- 培训努力·MGH内分泌部教授指导计划的共同指导·共同- 赞助HMS的导师讲习班，并·收到以下项目的正式认可 在指导方面表现出色。这项建议的主要指导目标是培养和支持 不同的、跨学科的临床研究人员小组的职业发展，都致力于 与WWH的健康相关的POR。我还渴望促进一种支持性、包容性的文化 通过指导编程方面的领导力进行指导。K24奖将为我提供受保护的时间 实现上述目标。MGH领导层承诺保护我的时间，以便让我 专注于POR和POR指导。导师的支持帮助我实现了我的梦想 成为一名独立的临床研究员。通过这个奖项，我寻求支持我的职业生涯 开发将催化突破性进展的新一代临床研究人员 在生物医学研究方面--所有这些都是为了病人的利益。