Consequences of Persistent Immune Activation among ART-treated Women with HIV

接受抗逆转录病毒治疗的艾滋病毒女性持续免疫激活的后果

• 批准号: 10669637
• 负责人: Markella V. Zanni
• 金额: $ 18.16万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10669637
• 关键词: Affect; Ancillary Study; Attention; Award; Biological; Biomedical Research; Biometry; Blood Vessels; Brain; CD8-Positive T-Lymphocytes; Cardiology; Cardiometabolic Disease; Cardiovascular system; Center for Translational Science Activities; Chronic; Clinical Investigator; Collaborations; Communities; Complement; Coronary; Dendritic Cells; Discipline; Disease; Dreams; Education; Educational workshop; Endocrine; Endocrinology; Enrollment; Environment; Epidemiology; Epigenetic Process; Event; Exhibits; Functional disorder; Funding; General Hospitals; Generations; Genes; Goals; HIV; HIV-1; Heart; Hormonal; Immune; Immune response; Immunology; Inflammation; Institution; Interferon alpha; Interferons; Kidney; Kidney Diseases; Lead; Leadership; Learning; Letters; Liver diseases; Lung; Massachusetts; Medicine; Mentors; Mentorship; Metabolism; Microvascular Dysfunction; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Neurocognitive; Organ; Outcome; Participant; Pathology; Patients; Pattern; Physiology; Public Health; Research; Research Institute; Research Personnel; Research Project Grants; Research Training; Risk; Risk Reduction; SARS-CoV-2 infection; Services; Sex Differences; T-Cell Activation; TLR7 gene; Testing; Time; Training; United States National Institutes of Health; Up-Regulation; Viral; Viremia; Virus; Woman; Women' s Health; Work; antiretroviral therapy; cardiovascular disorder risk; career; career development; catalyst; clinical translation; comorbidity; coronavirus disease; cytokine release syndrome; experience; faculty mentor; frailty; healthspan; immune activation; immunoregulation; insight; medical schools; men; mid-career faculty; patient oriented research; prevent; programs; randomized trial; reproductive senescence; research facility; response; risk selection; sex; skills; success

7. Project Summary The NIH Midcareer Investigator Award in Patient-Oriented Research (POR) (K24) will enable me to advance research on consequences of persistent immune activation among ART-treated women with HIV (WWH) while developing my mentoring leadership skills and providing research mentorship to a diverse, interdisciplinary group of clinical investigators. My overall career goals are to continue to lead a robust research program with a newly expanded scope: investigating not only how persistent systemic immune activation among ART-treated WWH influences cardiometabolic disease, but also how this phenomenon influences diverse end-organ comorbidities - including end-organ disease incurred in the context of superimposed SARS-CoV-2 infection. As an Associate Professor at Harvard Medical School (HMS) and the Director of Women’s Health Research in Massachusetts General Hospital (MGH) Metabolism Unit, I lead NIH R01-funded projects which will serve as an outstanding platform for mentoring. The collaborative research environment at MGH/HMS supports my work in this interdisciplinary field, permitting me to synthesize insights from outstanding colleagues expert in HIV medicine, immunology, cardiology, endocrinology, and women’s health. Facilities, curricular offerings, and consultative services sponsored by the Mass General Research Institute and the Harvard Catalyst Clinical Translational Science Center contribute to the success of collaborative research. The career development aims of this proposal are to pursue advanced didactic training in immunology and biostatistics, as well as advanced didactic training in mentoring leadership. These efforts will help me expand my research program and build on my longstanding commitment to mentoring - a commitment reflected in •successful 1:1 mentoring of trainees •contributions to MGH/HMS POR- training efforts •Co-Direction of the MGH Endocrine Division Faculty Mentoring Initiative •Co- Sponsorship of the Mentoring the Mentors Workshop at HMS and •receipt of formal recognition for excellence in mentoring. The primary mentoring aim of this proposal is to nurture and support the career development of a diverse, interdisciplinary group of clinical investigators, all committed to POR relevant to the health of WWH. I also aspire to promote a culture of supportive, inclusive mentoring through leadership in mentoring programming. The K24 award will offer me protected time to achieve the aforementioned goals. MGH leadership has pledged to protect my time so as to allow me to focus on POR and POR mentoring. Support from mentors has helped me follow my dream of becoming an independent clinical investigator. Through this award, I seek to support the career development of a new generation of clinical investigators who will catalyze ground-breaking advances in biomedical research -- all for the benefit of patients.

7。项目摘要 NIH中级护理研究员授予患者研究（POR）（K24）将使我能够 对经艺术治疗的妇女持续的免疫激活后果的提前研究 艾滋病毒（WWH）在发展我的心理领导能力时，并为 潜水员，跨学科的临床研究者小组。我的整体职业目标是继续领导 具有新扩展范围的强大研究计划：不仅要调查持久性 ART处理的WWH中的全身免疫激活会影响心脏代谢疾病，但也会影响 这种现象如何影响潜水员最终器官合并症 - 包括最终器官疾病 在叠加的SARS-COV-2感染的背景下发生。作为哈佛大学的副教授 医学院（HMS）和马萨诸塞州妇女健康研究主任 医院（MGH）代谢部门，我领导NIH R01资助的项目，该项目将成为一个杰出的项目 心理平台。 MGH/HMS的协作研究环境支持我的工作 跨学科领域，允许我综合杰出同事艾滋病毒专家的见解 医学，免疫学，心脏病学，内分泌学和妇女健康。设施，课程提供， 和大众研究所和哈佛催化剂赞助的咨询服务 临床转化科学中心为合作研究的成功做出了贡献。职业 该提案的发展目的是进行免疫学的先进教学培训和 生物统计学以及心理领导中的先进教学培训。这些努力会帮助我 扩大我的研究计划并以我对心理的长期承诺为基础 - •成功的1：1心理•对MGH/HMS的贡献 - 培训工作•MGH内分泌部教师指导倡议的共同指导•共同 在HMS的指导导师研讨会的赞助和•获得正式认可的 卓越的心理。该提议的主要心理目的是护理和支持 临床研究人员的潜水员跨学科小组的职业发展都承诺 与WWH的健康有关。我也渴望促进一种支持性，包容性的文化 通过领导力指导编程指导。 K24奖将为我提供受保护的时间 MGH领导人一直在保护我的时间，以便让我 专注于POR和POR心理。 Mentals的支持帮助我遵循了我的梦想 成为独立的临床研究者。通过这个奖项，我寻求支持职业 开发新一代的临床研究人员，他们将催化突破性的进步 在生物医学研究中 - 全部用于患者的好处。

项目成果

Atherosclerosis With Immune Checkpoint Inhibitor Therapy: Evidence, Diagnosis, and Management: JACC: CardioOncology State-of-the-Art Review.

• DOI: 10.1016/j.jaccao.2022.11.011
• 发表时间: 2022-12
• 期刊: JACC: CARDIOONCOLOGY
• 影响因子: 11.1
• 作者: Suero-Abreu, Giselle Alexandra;Zanni, Markella, V;Neilan, Tomas G.
• 通讯作者: Neilan, Tomas G.