Consequences of Persistent Immune Activation among ART-treated Women with HIV

接受抗逆转录病毒治疗的艾滋病毒女性持续免疫激活的后果

• 批准号: 10669637
• 负责人: Markella V. Zanni
• 金额: $ 18.16万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10669637
• 关键词: Affect; Ancillary Study; Attention; Award; Biological; Biomedical Research; Biometry; Blood Vessels; Brain; CD8-Positive T-Lymphocytes; Cardiology; Cardiometabolic Disease; Cardiovascular system; Center for Translational Science Activities; Chronic; Clinical Investigator; Collaborations; Communities; Complement; Coronary; Dendritic Cells; Discipline; Disease; Dreams; Education; Educational workshop; Endocrine; Endocrinology; Enrollment; Environment; Epidemiology; Epigenetic Process; Event; Exhibits; Functional disorder; Funding; General Hospitals; Generations; Genes; Goals; HIV; HIV-1; Heart; Hormonal; Immune; Immune response; Immunology; Inflammation; Institution; Interferon alpha; Interferons; Kidney; Kidney Diseases; Lead; Leadership; Learning; Letters; Liver diseases; Lung; Massachusetts; Medicine; Mentors; Mentorship; Metabolism; Microvascular Dysfunction; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Neurocognitive; Organ; Outcome; Participant; Pathology; Patients; Pattern; Physiology; Public Health; Research; Research Institute; Research Personnel; Research Project Grants; Research Training; Risk; Risk Reduction; SARS-CoV-2 infection; Services; Sex Differences; T-Cell Activation; TLR7 gene; Testing; Time; Training; United States National Institutes of Health; Up-Regulation; Viral; Viremia; Virus; Woman; Women' s Health; Work; antiretroviral therapy; cardiovascular disorder risk; career; career development; catalyst; clinical translation; comorbidity; coronavirus disease; cytokine release syndrome; experience; faculty mentor; frailty; healthspan; immune activation; immunoregulation; insight; medical schools; men; mid-career faculty; patient oriented research; prevent; programs; randomized trial; reproductive senescence; research facility; response; risk selection; sex; skills; success

7. Project Summary The NIH Midcareer Investigator Award in Patient-Oriented Research (POR) (K24) will enable me to advance research on consequences of persistent immune activation among ART-treated women with HIV (WWH) while developing my mentoring leadership skills and providing research mentorship to a diverse, interdisciplinary group of clinical investigators. My overall career goals are to continue to lead a robust research program with a newly expanded scope: investigating not only how persistent systemic immune activation among ART-treated WWH influences cardiometabolic disease, but also how this phenomenon influences diverse end-organ comorbidities - including end-organ disease incurred in the context of superimposed SARS-CoV-2 infection. As an Associate Professor at Harvard Medical School (HMS) and the Director of Women’s Health Research in Massachusetts General Hospital (MGH) Metabolism Unit, I lead NIH R01-funded projects which will serve as an outstanding platform for mentoring. The collaborative research environment at MGH/HMS supports my work in this interdisciplinary field, permitting me to synthesize insights from outstanding colleagues expert in HIV medicine, immunology, cardiology, endocrinology, and women’s health. Facilities, curricular offerings, and consultative services sponsored by the Mass General Research Institute and the Harvard Catalyst Clinical Translational Science Center contribute to the success of collaborative research. The career development aims of this proposal are to pursue advanced didactic training in immunology and biostatistics, as well as advanced didactic training in mentoring leadership. These efforts will help me expand my research program and build on my longstanding commitment to mentoring - a commitment reflected in •successful 1:1 mentoring of trainees •contributions to MGH/HMS POR- training efforts •Co-Direction of the MGH Endocrine Division Faculty Mentoring Initiative •Co- Sponsorship of the Mentoring the Mentors Workshop at HMS and •receipt of formal recognition for excellence in mentoring. The primary mentoring aim of this proposal is to nurture and support the career development of a diverse, interdisciplinary group of clinical investigators, all committed to POR relevant to the health of WWH. I also aspire to promote a culture of supportive, inclusive mentoring through leadership in mentoring programming. The K24 award will offer me protected time to achieve the aforementioned goals. MGH leadership has pledged to protect my time so as to allow me to focus on POR and POR mentoring. Support from mentors has helped me follow my dream of becoming an independent clinical investigator. Through this award, I seek to support the career development of a new generation of clinical investigators who will catalyze ground-breaking advances in biomedical research -- all for the benefit of patients.

7.项目摘要 NIH职业中期研究者奖以患者为导向的研究（POR）（K24）将使我能够 关于ART治疗女性中持续免疫激活后果的进一步研究 艾滋病毒（WWH），同时发展我的指导领导技能，并提供研究指导，以 多元化的跨学科临床研究者团队。我的总体职业目标是继续领导 一个强大的研究计划，新扩大的范围：调查不仅如何持久 ART治疗的WWH中的全身免疫激活影响心脏代谢疾病，但也 这种现象如何影响各种终末器官合并症-包括终末器官疾病 在叠加SARS-CoV-2感染的情况下发生。作为哈佛的副教授 医学院（HMS）和妇女健康研究主任在马萨诸塞州一般 医院（MGH）代谢单位，我领导NIH R 01资助的项目，这将作为一个杰出的 指导的平台。MGH/HMS的合作研究环境支持我在这方面的工作。 跨学科领域，使我能够综合艾滋病毒专家杰出同事的见解 医学、免疫学、心脏病学、内分泌学和妇女健康。设施，课程设置， 由麻省总研究所和哈佛催化剂赞助的咨询服务 临床转化科学中心有助于合作研究的成功。职业 该提案的发展目标是追求免疫学的高级教学培训， 生物统计学，以及指导领导方面的高级教学培训。这些努力将帮助我 扩大我的研究计划，并建立在我长期致力于指导- a 承诺反映在·成功的1：1指导学员·对MGH/HMS POR的贡献- 培训工作·MGH内分泌部教师指导计划的共同方向·共同- 赞助HMS的导师工作坊，并获得 卓越的指导。本提案的主要指导目标是培养和支持 一个多元化的，跨学科的临床研究者群体的职业发展，所有致力于 与WWH的健康相关的POR。我还渴望促进一种支持、包容、 通过在指导方案编制方面的领导作用进行指导。K24奖将为我提供受保护的时间 实现上述目标。麻省总医院的领导保证保护我的时间 专注于POR和POR指导。导师们的支持帮助我实现了我的梦想， 成为一名独立的临床研究者。通过这个奖项，我寻求支持职业生涯 培养新一代的临床研究人员，他们将促进突破性的进展 都是为了病人的利益。

项目成果

Atherosclerosis With Immune Checkpoint Inhibitor Therapy: Evidence, Diagnosis, and Management: JACC: CardioOncology State-of-the-Art Review.

• DOI: 10.1016/j.jaccao.2022.11.011
• 发表时间: 2022-12
• 期刊: JACC: CARDIOONCOLOGY
• 影响因子: 11.1
• 作者: Suero-Abreu, Giselle Alexandra;Zanni, Markella, V;Neilan, Tomas G.
• 通讯作者: Neilan, Tomas G.