A New Approach for Measurement of Electrical Conductivities of Cardiac Tissues

测量心脏组织电导率的新方法

基本信息

  • 批准号:
    10162414
  • 负责人:
  • 金额:
    $ 7.75万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-06-01 至 2023-03-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT The applicants’ long-term aim is to support the further advancement and clinical translation of computational models of cardiac tissues. Crucial parameters for computational models of tissue electrophysiology are the intra- and extracellular electrical conductivities. Currently, our knowledge about these conductivities originates from a small set of studies performed 40 years ago on ventricular tissue from animal hearts. Conductivities of human, aged and diseased tissues have still not been established. In this study, we will test the hypothesis that a novel computational approach and advanced 3D microelectrode arrays provide a means for accurate measurement of conductivities for modeling of cardiac tissue electrophysiology. Our approach will facilitate the measurement of conductivity tensors that comprehensively describe the anisotropic electrical properties of the extracellular and intracellular domains of biological tissue. In Specific Aim 1, we will use the computational approach to assess designs of 3D microelectrode arrays and current application protocols. We will vary the spacing of recording electrodes within the degrees of freedom for manufacturing of the microelectrode arrays. We will also investigate protocols and electrode locations for current application. The optimal array and current application protocol will be further assessed in studies on tissue surrogates. In these studies, we hypothesize that the modeling-based approach is capable of accurately measuring the conductivity of both isotropic and anisotropic media. We will determine the accuracy of the conductivity measurements. In Specific Aim 2, we will explore the utility of the modeling-based approach for measurement of conductivity in living cardiac tissues. Using tissues excised from the left ventricle of rat, we will test the hypothesis that the computational approach provides reliable measures of conductivity of living tissues. We will assess our measurements by comparison with prior studies. Subsequently, we will investigate the feasibility of the approach for conductivity measurements of the left ventricular free wall of the isolated rat heart. We will apply an established model of the isolated rat heart based on retrograde perfusion through the aorta. We will perfuse the hearts with solutions associated with normal, increased and decreased extracellular volume. We hypothesize that extracellular conductivities increase and decrease for the solutions that increase and decrease the extracellular volume, respectively, when compared to control. Together, the proposed studies constitute a crucial step towards establishing the proposed innovative approach for measurement of intra- and extracellular conductivities. Applications of the proposed framework include establishing conductivities of cardiac tissues at different sites of the human and aged heart. Also, application of the framework will facilitate the creation of a library of conductivity measurements for various cardiac diseases, for instance, hypertrophic cardiomyopathy and ventricular fibrosis. We suggest that such a library will have a sustained, powerful impact on computational cardiovascular research and medicine.
项目总结/摘要 申请人的长期目标是支持计算免疫球蛋白的进一步发展和临床转化。 心脏组织模型。组织电生理学的计算模型的关键参数是组织电生理学的内部参数。 和细胞外电导率。目前,我们对这些电导率的了解来自于 这是40年前对动物心脏的心室组织进行的一系列研究。人类的电导率, 衰老和病变的组织还没有建立起来。在这项研究中,我们将测试一个假设, 计算方法和先进的3D微电极阵列提供了一种精确测量 用于心脏组织电生理学建模的电导率。我们的方法将有助于衡量 电导率张量,全面描述了细胞外的各向异性电特性, 生物组织的细胞内区域。在具体目标1中,我们将使用计算方法来评估 3D微电极阵列的设计和当前的应用方案。我们将改变记录的间隔 用于制造微电极阵列的自由度内的电极。我们亦会研究 当前应用的协议和电极位置。最佳阵列和当前应用程序协议将 在组织替代物研究中进一步评估。在这些研究中,我们假设基于模型的 该方法能够准确测量各向同性和各向异性介质的电导率。我们将 确定电导率测量的准确性。在具体目标2中,我们将探讨 测量活体心脏组织电导率的基于建模的方法。利用从 大鼠左心室,我们将测试的假设,计算方法提供了可靠的措施, 活体组织的导电性。我们将通过与先前研究的比较来评估我们的测量结果。 随后,我们将调查的可行性的方法电导率测量的左 离体大鼠心脏的心室游离壁。我们将应用建立的离体大鼠心脏模型, 通过主动脉逆行灌注。我们会用正常的, 增加和减少细胞外容积。我们假设细胞外电导率增加, 与对照组相比,增加和减少细胞外容积的溶液分别减少 控制这些拟议的研究共同构成了建立拟议的创新机制的关键一步。 测量细胞内和细胞外电导率的方法。拟议框架的应用 包括在人和老年心脏的不同部位建立心脏组织的电导率。还有, 该框架的应用将有助于创建各种电导率测量的库 心脏疾病,例如肥厚型心肌病和心室纤维化。我们建议, 图书馆将对计算心血管研究和医学产生持续,强大的影响。

项目成果

期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Approaches for determining cardiac bidomain conductivity values: progress and challenges.
A modified approach to determine the six cardiac bidomain conductivities.
Confocal microscopy-based estimation of intracellular conductivities in myocardium for modeling of the normal and infarcted heart.
Improving the accuracy of retrieved cardiac electrical conductivities.
  • DOI:
    10.21914/anziamj.v63.17148
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
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Derek J Dosdall其他文献

Cardiac ECV is more robust than post-contrast cardiac T<sub>1</sub> for evaluating temporal changes in LV fibrosis
  • DOI:
    10.1186/1532-429x-16-s1-p25
  • 发表时间:
    2014-01-16
  • 期刊:
  • 影响因子:
  • 作者:
    Kyungpyo Hong;Matthias Koopmann;Eugene G Kholmovski;Eric C Huang;Nan Hu;Richard Levenson;Sathya Vijayakumar;Derek J Dosdall;Ravi Ranjan;Daniel Kim
  • 通讯作者:
    Daniel Kim
Inter-subject variation in partition coefficient is largely due to variation in LGE blood T1
  • DOI:
    10.1186/1532-429x-15-s1-p48
  • 发表时间:
    2013-01-30
  • 期刊:
  • 影响因子:
  • 作者:
    Kyung P Hong;Eugene Kholmovski;Sathya Vijayakumar;Derek J Dosdall;Christopher McGann;Ravi Ranjan;Nassir F Marrouche;Daniel Kim
  • 通讯作者:
    Daniel Kim

Derek J Dosdall的其他文献

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{{ truncateString('Derek J Dosdall', 18)}}的其他基金

Novel lead for selective His bundle sensing and low-threshold pacing
用于选择性希束传感和低阈值起搏的新型导线
  • 批准号:
    10421275
  • 财政年份:
    2021
  • 资助金额:
    $ 7.75万
  • 项目类别:
Antitachycardia pacing and improved lead for ventricular conduction system stimulation
抗心动过速起搏和改善心室传导系统刺激的导联
  • 批准号:
    10478220
  • 财政年份:
    2015
  • 资助金额:
    $ 7.75万
  • 项目类别:
His-Purkinje Pacing for Low Energy Implantable Cardioverter Defibrillators
用于低能量植入式心脏复律除颤器的希氏浦肯野起搏
  • 批准号:
    8944632
  • 财政年份:
    2015
  • 资助金额:
    $ 7.75万
  • 项目类别:
Antitachycardia pacing and improved lead for ventricular conduction system stimulation
抗心动过速起搏和改善心室传导系统刺激的导联
  • 批准号:
    10677873
  • 财政年份:
    2015
  • 资助金额:
    $ 7.75万
  • 项目类别:
Antitachycardia pacing and improved lead for ventricular conduction system stimulation
抗心动过速起搏和改善心室传导系统刺激的导联
  • 批准号:
    10298724
  • 财政年份:
    2015
  • 资助金额:
    $ 7.75万
  • 项目类别:
Role of the Purkinje System in Long Duration Ventricular Fibrillation
浦肯野系统在长时心室颤动中的作用
  • 批准号:
    8437167
  • 财政年份:
    2010
  • 资助金额:
    $ 7.75万
  • 项目类别:
Role of the Purkinje System in Long Duration Ventricular Fibrillation
浦肯野系统在长时心室颤动中的作用
  • 批准号:
    8119222
  • 财政年份:
    2010
  • 资助金额:
    $ 7.75万
  • 项目类别:
Role of the Purkinje System in Long Duration Ventricular Fibrillation
浦肯野系统在长时心室颤动中的作用
  • 批准号:
    8135290
  • 财政年份:
    2010
  • 资助金额:
    $ 7.75万
  • 项目类别:
Role of the Purkinje System in Long Duration Ventricular Fibrillation
浦肯野系统在长时心室颤动中的作用
  • 批准号:
    7662604
  • 财政年份:
    2009
  • 资助金额:
    $ 7.75万
  • 项目类别:

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