Developmental Determinants of Cardiovascular Disease

心血管疾病的发育决定因素

• 批准号: 10164843
• 负责人: H Scott Baldwin
• 金额: $ 34.95万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10164843
• 关键词: Cardiovascular Diseases; Development

This is the first renewal of the T32 application from Division of Pediatric Cardiology, Vanderbilt University School of Medicine. By advancing a program that integrates formal training in research on developmental determinants of cardiovascular disease with clinical training in pediatric cardiology, we will provide a unique training environment that will foster development of academic pediatric cardiologists. This training program will not only focus on the molecular and genetic etiologies of congenital heart disease, but will also emphasize the impact of pre- and postnatal development in defining the manifestations of cardiovascular pathology after birth. In addition to trainees in the Pediatric Cardiology, clinical or Ph.D. post-doctoral fellows who have an expressed interest in investigating development mechanisms of cardiovascular disease will be eligible for support. We are requesting continued support for 3 trainees / year for two years for a total of 6 trainees / year for a five year period. This program will provide a unique opportunity for trainees to study the recapitulation of normal developmental processes in the ontogeny of cardiovascular pathology presenting later in childhood or adulthood. The program will be composed of two tracks optimized either for pursuit of preparation for (1) basic science investigation or (2) clinical or translational research. A focused, mentored, laboratory experience with targeted didactic interactions will be tailored to meet the needs of those pursing a more basic science career. For trainees pursuing a career in clinical or translational medicine, the Vanderbilt Master of Science in Clinical Investigation (MSCI) program will be an integral part of the training program. Candidates will be identified from the pool of applicants applying for a pediatric cardiology fellowship (112 applicants for 3 positions in 2017) as well as from talented clinical and post-doctoral fellows throughout Vanderbilt University. During a first clinical year of pediatric cardiology fellowship (PGY-4) the candidates will be matched with mentors and together, they will decide upon a research project. During the second and third years of a four year fellowship, trainees will carry out a mentored research project. During the fourth year, the trainee will complete clinical training with the option of advanced training in a sub-subspecialty as well as continued research and submission of a K08 or K23 application. This grant will provide support for the second and third years of protected research training. The Department of Pediatrics is committed to complete support of fellows during the first and fourth years as well as supplementing support provided by this grant in years two and three. Using the unique strengths of Vanderbilt University in the areas of cardiac development and regeneration, myocardial biology, pulmonary biology and pulmonary hypertension, cardiovascular genetics and pharmacogenomics, vascular biology and atherosclerosis, as well as cardiovascular outcomes based research and bioinformatics, the program will help train the next generation of physician scientists focused on pediatric cardiovascular disease.

这是范德比尔特大学儿科心脏病学分部首次更新T32申请 医学院。通过推进一项将正规培训与发展研究相结合的计划， 心血管疾病的决定因素与儿科心脏病学的临床培训，我们将提供一个独特的 培训环境，将促进学术儿科心脏病专家的发展。该培训计划将 不仅关注先天性心脏病的分子和遗传病因， 产前和产后发育对确定出生后心血管病理表现的影响。 除了儿科心脏病学，临床或博士学位的受训者外，博士后研究员谁有一个 表示有兴趣研究心血管疾病的发展机制将有资格获得 支持.我们要求继续支持每年3名受训人员，为期两年，每年总共6名受训人员 为期五年。该计划将为学员提供一个独特的机会，学习概括的 在儿童期后期出现的心血管病理学个体发育中的正常发育过程，或 成年该计划将由两个轨道优化要么追求准备（1）基本 科学研究或（2）临床或转化研究。一个专注的，指导，实验室经验， 有针对性的教学互动将根据那些追求更基础的科学事业的需要而调整。 对于追求临床或转化医学职业生涯的学员，范德比尔特临床科学硕士 调查（MSCI）计划将是培训计划的一个组成部分。候选人将被确定为 申请儿科心脏病学奖学金的申请人（2017年3个职位的112名申请人）， 以及来自范德比尔特大学有才华的临床和博士后研究员。在第一次临床 一年的儿科心脏病学奖学金（PGY-4）的候选人将与导师匹配，他们一起， 将决定一个研究项目。在为期四年的研究金的第二年和第三年，学员将 开展一个有指导的研究项目。在第四年，受训者将完成临床培训， 选择子专业的高级培训以及继续研究和提交K 08或 K23应用这笔赠款将为第二年和第三年的受保护研究培训提供支持。 儿科系致力于在第一年和第四年为研究员提供全面的支持， 以及在第二年和第三年由该赠款提供的补充支助。利用其独特的优势， 范德比尔特大学在心脏发育和再生，心肌生物学，肺 生物学和肺动脉高压，心血管遗传学和药物基因组学，血管生物学和 动脉粥样硬化，以及心血管结果为基础的研究和生物信息学，该计划将有助于 培养下一代专注于儿科心血管疾病的医生科学家。