Targeted drug discovery against blood-feeding parasite nematodes of animals

针对动物吸血寄生虫线虫的靶向药物发现

• 批准号: DP210101500
• 负责人: Prof Nicola Harris
• 金额: $ 31.3万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-08-31 至 2025-05-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210101500
• 关键词: Targeted; drug; discovery; against; blood

This project aims to identify more sustainable control strategies of nematode parasites of livestock, which cost more than 400 million yearly to the Australian wool and meat industry. The project expects to identify novel nematicides and generate knowledge of the parasite biology using a combination of high-throughput drug discovery screens with cutting-edge OMICs approaches to target a key molecular pathway of importance to the survival of nematodes, namely their blood-feeding behaviour. Expected outcomes of this project include a likely enhancement of international efforts in controlling these parasites as well as nematicides commercialisation. This should provide significant benefits to agricultural producers in Australia and worldwide.

该项目旨在确定牲畜线虫寄生虫的更可持续的控制策略，这对澳大利亚羊毛和肉类行业每年的成本超过4亿美元。该项目预计将确定新型杀线虫剂，并使用高通量药物发现筛选与尖端OMIC方法相结合来产生寄生虫生物学知识，以靶向对线虫生存具有重要意义的关键分子途径，即其吸血行为。该项目的预期成果包括可能加强控制这些寄生虫的国际努力以及杀线虫剂的商业化。这将为澳大利亚和世界各地的农业生产者带来巨大利益。