Evaluating Chinese-speaking community-dwelling elders in the United States with the Uniform Data Set

项目摘要 痴呆症是65岁或以上成年人的常见疾病。认知测试可以提高诊断 老年痴呆症华裔老年人诊断不准确或延误的风险很高 由于缺乏认知测试的规范性数据而诊断为痴呆。阿尔茨海默病 美国各地的ADC评估正常衰老、轻度认知障碍（MCI）、阿尔茨海默氏症（AD） 疾病（AD）和其他类型的老年人痴呆症使用国家阿尔茨海默氏症协调中心的 统一数据集（NACC UDS）评价。评估包括临床面试，体检， 认知测试和功能评估用于载脂蛋白E ε4（APOE ε4）基因分型的血液采集是 通常作为标准痴呆症评估的一部分完成。来自几种文化和人群的数据 在UDS认知测试中已有报道，但在讲汉语的个体中的报道很少。的 NACC正在努力收集中国人口的UDS数据。然而，认知数据 在中国的中国人可能不会被推广到在美国的中国人。鉴于美国经济增长 中国人口，以及他们对痴呆症护理的需求日益增加，开发规范性数据至关重要， 为认知缺陷的确定提供精确度。拟议的研究旨在生成UDS 认知数据使用了一组年龄和教育程度范围广泛的健康老年华裔美国人。 成就为了证明认知测试的敏感性，我们将评估认知功能与认知功能之间的关系。 性能与人口统计（例如，年龄、性别和教育），经验（例如，年和年龄到达 美国），临床（例如，认知状态、日常生活活动和行为症状），以及 遗传变量（例如，APOE ε4）。参与者必须认知正常，主要讲中文， 65岁或以上。所有参与者将接受3小时的NACC UDS评估。中国 NACC UDS文件的翻译将由中英双语工作人员在 西奈山伊坎医学院阿尔茨海默病研究中心（ADRC）。基于 根据我们之前招募老年华裔美国人进行临床研究的经验，我们预计将招募150名 正常对照组在2年内。回归模型将被用来检查认知的关系， 与人口统计学，经验，临床和遗传变量的性能。ISMMS的ADRC已经 在美国成功招募和评估讲西班牙语的长者。本项目建立在此基础上 经验来评估老年华裔美国人，在美国增长最快的少数群体。我们的结果 将支持开发用于检测和诊断认知衰退的规范性数据， 老年痴呆症的发病率这些数据还将提供有价值的跨国比较， 为NACC数据库增加价值。

Project Summary Dementia is a common disorder in adults aged 65 or above. Cognitive tests can improve the diagnosis of dementia in older adults. Elderly Chinese Americans have a high risk of inaccurate diagnosis or delayed diagnosis of dementia due to the absence of normative data on cognitive tests. The Alzheimer Disease Centers (ADCs) around the United States assess normal aging, Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD), and other types of dementia in older adults using the National Alzheimer's Coordinating Center's Uniform Data Set (NACC UDS) evaluation. The evaluation consists of a clinical interview, medical exam, cognitive testing, and functional assessment. Blood collection for Apolipoprotein E ε4 (APOE ε4) genotyping is commonly completed as part of the standard dementia evaluation. Data from several cultures and populations have been reported for UDS cognitive tests but few reports in Chinese speaking individuals are available. The NACC is working to collect UDS data for the Chinese population in China. However, cognitive data for Chinese in China might not be generalized to the Chinese population in the US. Given the growing US Chinese population, and their increasing need for dementia care, it is critical to develop normative data to provide precision in the determination of cognitive deficit. The proposed study is designed to generate UDS cognitive data using a cohort of healthy elderly Chinese Americans with a wide range of age and educational attainment. To demonstrate the sensitivity of the cognitive tests, we will assess the relationship of cognitive performance with demographic (e.g., age, gender, and education), experiential (e.g., year and age arrived at the United States), clinical (e.g., cognitive status, activities of daily living, and behavioral symptoms), and genetic variables (e.g., APOE ε4). Participants must be cognitively normal, primarily Chinese speaking, and aged 65 or above. All enrollees will undergo a 3-hour in-person NACC UDS evaluation. The Chinese translation of the NACC UDS instruments will be administered by the bilingual English/Chinese staff at the Alzheimer's Disease Research Center (ADRC) at Icahn School of Medicine at Mount Sinai (ISMMS). Based on our prior recruitment experience of elderly Chinese Americans for clinical study, we expect to enroll 150 normal controls in a 2-year period. Regression models will be used to examine the relationship of cognitive performance with demographic, experiential, clinical, and genetic variables. The ADRC at ISMMS has been successful in recruiting and evaluating Spanish speaking elders in the US. This project builds on this experience to evaluate elderly Chinese Americans, the fastest growing minority group in the US. Our results will support the development of normative data for the detection and diagnosis of cognitive decline and dementia in this underserved population. The data will also provide valuable cross-country comparison and add value to the NACC database.