Evaluating Chinese-speaking community-dwelling elders in the United States with the Uniform Data Set

用统一数据集评估美国社区华语老年人

• 批准号: 10170514
• 负责人: Clara Li
• 金额: $ 12.74万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-15 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10170514
• 关键词: Activities of Daily Living; Adherence; Administrative Supplement; Adult; Affect; Age; Alzheimer' s Disease; Apolipoprotein E; Awareness; Behavior assessment; Behavioral Symptoms; Blood; COVID-19; COVID-19 pandemic; China; Chinese American; Chinese People; Clinical; Clinical Research; Cognition; Cognitive; Cognitive deficits; Cohort Studies; Collection; Communities; Contracts; Country; Data; Data Collection; Data Set; Databases; Dementia; Detection; Development; Diagnosis; Diagnostic; Disasters; Disease; Education; Elderly; Enrollment; Ensure; Evaluation; Exposure to; Funding; Gender; Genetic; Genotype; Goals; Handwashing; Health behavior; Hour; Impaired cognition; Individual; Interview; Knowledge; Language; Masks; Measures; Medical; Medical Genetics; Methodology; Methods; Minority Groups; Modeling; Morbidity - disease rate; Neuropsychological Tests; Normal Range; Participant; Persons; Population; Prevention; Reporting; Research; Risk; Risk Management; Sampling; Services; Shelter facility; Social Distance; Surveys; Techniques; Telephone; Test Result; Testing; Time; Translations; Travel; Underserved Population; United States; United States National Institutes of Health; Virus; aged; base; bilingualism; cognitive performance; cognitive testing; cohort; comparative; dementia care; design; ethnic minority population; experience; high risk; high risk population; improved; instrument; medical schools; mild cognitive impairment; mortality; normal aging; pandemic disease; parent grant; racial minority; recruit; response; risk mitigation; socioeconomic disadvantage; tool; uptake

Project Summary Dementia is a common disorder in adults aged 65 or above. Cognitive tests can improve the diagnosis of dementia in older adults. Elderly Chinese Americans have a high risk of inaccurate diagnosis or delayed diagnosis of dementia due to the absence of normative data on cognitive tests. The Alzheimer Disease Centers (ADCs) around the United States assess normal aging, Mild Cognitive Impairment (MCI), Alzheimer's Disease (AD), and other types of dementia in older adults using the National Alzheimer's Coordinating Center's Uniform Data Set (NACC UDS) evaluation. The evaluation consists of a clinical interview, medical exam, cognitive testing, and functional assessment. Blood collection for Apolipoprotein E ε4 (APOE ε4) genotyping is commonly completed as part of the standard dementia evaluation. Data from several cultures and populations have been reported for UDS cognitive tests but few reports in Chinese speaking individuals are available. The NACC is working to collect UDS data for the Chinese population in China. However, cognitive data for Chinese in China might not be generalized to the Chinese population in the US. Given the growing US Chinese population, and their increasing need for dementia care, it is critical to develop normative data to provide precision in the determination of cognitive deficit. The proposed study is designed to generate UDS cognitive data using a cohort of healthy elderly Chinese Americans with a wide range of age and educational attainment. To demonstrate the sensitivity of the cognitive tests, we will assess the relationship of cognitive performance with demographic (e.g., age, gender, and education), experiential (e.g., year and age arrived at the United States), clinical (e.g., cognitive status, activities of daily living, and behavioral symptoms), and genetic variables (e.g., APOE ε4). Participants must be cognitively normal, primarily Chinese speaking, and aged 65 or above. All enrollees will undergo a 3-hour in-person NACC UDS evaluation. The Chinese translation of the NACC UDS instruments will be administered by the bilingual English/Chinese staff at the Alzheimer's Disease Research Center (ADRC) at Icahn School of Medicine at Mount Sinai (ISMMS). Based on our prior recruitment experience of elderly Chinese Americans for clinical study, we expect to enroll 150 normal controls in a 2-year period. Regression models will be used to examine the relationship of cognitive performance with demographic, experiential, clinical, and genetic variables. The ADRC at ISMMS has been successful in recruiting and evaluating Spanish speaking elders in the US. This project builds on this experience to evaluate elderly Chinese Americans, the fastest growing minority group in the US. Our results will support the development of normative data for the detection and diagnosis of cognitive decline and dementia in this underserved population. The data will also provide valuable cross-country comparison and add value to the NACC database.

项目摘要 痴呆症是65岁或更高成年人的常见疾病。认知测试可以改善 老年人的痴呆症。中国美国人的诊断不准确或延迟的高风险 由于缺乏认知测试的正常数据，痴呆症的诊断。阿尔茨海默氏病 美国评估正常老化，轻度认知障碍（MCI），阿尔茨海默氏症的中心（ADC） 使用国家阿尔茨海默氏症协调中心的疾病（AD）和其他类型的痴呆症 统一数据集（NACC UDS）评估。评估包括临床访谈，体检， 认知测试和功能评估。载脂蛋白Eε4（APOEε4）基因分型的血液收集是 通常作为标准痴呆评估的一部分完成。来自几种文化和人群的数据 已经报告了UDS认知测试的报道，但是中文个人的报道很少。这 NACC正在努力为中国中国人口收集UDS数据。但是， 中国的中国人可能不会被普遍推广到美国的中国人口。鉴于我们正在成长 中国人口以及他们对痴呆症护理的日益增长的需求，开发正常数据至关重要 在确定认知缺陷的确定方面提供精度。拟议的研究旨在产生UDS 认知数据使用一系列健康的中年美国人，年龄和教育范围很广泛 素养。为了证明认知测试的敏感性，我们将评估认知的关系 人口统计学表现（例如，年龄，性别和教育），专家（例如，年龄和年龄到达 美国），临床（例如，认知状况，日常生活活动和行为症状），以及 遗传变量（例如APOEε4）。参与者必须在认知上是正常的，中文的话，并且 年龄65岁。所有注册者将接受3小时的面对面NACC UDS评估。中国人 NACC UDS仪器的翻译将由双语英语/中国员工管理 西奈山（ISMMS）的伊坎医学院的阿尔茨海默氏病研究中心（ADRC）。基于 关于我们以前在临床研究的中国美国人的招聘经验，我们预计将注册150 正常对照在2年内。回归模型将用于检查认知的关系 人口统计学，专家，临床和遗传变量的表现。 ISMM的ADRC已经 在美国成功招募和评估西班牙语长老。这个项目以此为基础 评估老年人的经验，即美国增长最快的少数群体。我们的结果 将支持开发正常数据，以检测和诊断认知能力下降和诊断 在这个服务不足的人群中的痴呆症。数据还将提供有价值的越野比较，并且 将值添加到NACC数据库中。