Identifying risk factors of Alzheimer's disease and related dementias in older Chinese immigrants

识别老年中国移民阿尔茨海默病和相关痴呆症的危险因素

• 批准号: 10448917
• 负责人: Clara Li
• 金额: $ 49.51万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-01 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10448917
• 关键词: Acculturation; Activities of Daily Living; Affect; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Apolipoproteins; Area; Asia; Asian Americans; Assessment tool; Attention; Blood Vessels; Characteristics; Chinese; Chinese American; Chinese population; Cities; Cognition; Cognitive; Cohort Studies; Country; Data; Dementia; Development; Disease; Education; Elderly; Empirical Research; Evaluation; Fibrinogen; Gender; Genetic Risk; Goals; Health; Health Policy; Heterogeneity; Hispanic; Hispanic Populations; Immigrant; Immigration; Impaired cognition; Impairment; Individual; Intervention; Investigation; Language; Length of Stay; Life; Link; Literature; Measurement; Measures; Mediating; Mediator of activation protein; Medical; Memory; Mental Depression; New York City; Older Population; Outcome; Play; Policies; Population; Prevalence; Recording of previous events; Registries; Reporting; Research; Risk; Role; Screening procedure; Shapes; Subgroup; Testing; Work; bilingualism; clinical practice; cognitive change; cognitive function; cohort; demographics; design; disorder risk; disparity reduction; executive function; experience; follow-up; functional status; genetic risk factor; global health; health care disparity; high risk; modifiable risk; prevent; programs; psychologic; racial and ethnic disparities; recruit; risk variant; sex

Project Summary Chinese immigrant population has been increasing for the last few decades. Despite their increasing numbers, very little is known about the health of Chinese immigrants. As the immigrant population becomes older, there is a pressing need to understand their cognitive health and risk of developing Alzheimer’s Disease and Related disorder (AD/ADRD), a common health problem in older individuals. AD/ADRD is a loss of cognitive function – ability to think, remember, or reason – to such an extent that it interferes with an individual’s day-to-day life and activities. Among all the study on immigration and cognition, only a few of them was focused specifically on Chinese immigrants. To date, existing findings on the linkages of immigration and cognition are mixed. Some studies reported worse cognitive function in immigrants than the US-born, whereas others found better cognitive function or no difference. In terms of measurement, immigration measures were limited to country born, age at immigration, and length of stay. Very little attention has been given to the influence of pre-immigration (e.g., reasons for immigration and early-life conditions) and post-immigration experiences (e.g., acculturation) on cognitive changes. In addition, cognitive function was largely defined by global cognition. Little is known regarding the effect of immigration on changes in specific cognitive domains, including areas of memory, executive function, and language (known as early cognitive markers of AD/ADRD). Previous studies have reported clusters of factors which explain the relationship between immigration and cognition, including: age, gender, education, depression, vascular health, and genetic risk factors. New York City has by far the highest Chines population of any city outside Asia. The Alzheimer’s Disease Research Center (ADRC) at Mount Sinai, located in New York City, has a successful record of engaging and evaluating Chinese American older adults, with an existing cohort of over 200 older Chinese immigrants who were fully characterized according to demographic variables, medical illnesses, psychological conditions, functional status, and genetic risks following a standard dementia evaluation. The purpose of this study is to expand the dementia evaluation to include measures of pre- and post-immigration experiences. We aim to: (1) elucidate the associations between immigration and cognition using comprehensive measures of immigration history along with a cognitive re- evaluation; and (2) identify potential mediators and moderators influencing such associations by leveraging the fullness of the baseline data. 100 well-characterized older Chinese immigrants will be recruited from the ADRC at Mount Sinai for the proposed study. This study will provide preliminary data for a larger study to examine the associations between immigration and cognition among older Chinese immigrants. Understanding mechanisms through which immigration experiences influence cognitive outcomes among the immigrant population will guide the development of tailored interventions to prevent AD/ADRD.

项目摘要 过去几十年来，中国移民人口一直在增加。尽管它们的数量在不断增加， 人们对中国移民的健康状况知之甚少。随着移民人口的老龄化，出现了 迫切需要了解他们的认知健康和患阿尔茨海默病及相关疾病的风险 精神障碍(AD/ADRD)，老年人常见的健康问题。AD/ADRD是认知功能的丧失- 思考、记忆或推理的能力--在某种程度上干扰个人的日常生活和 活动。在所有关于移民和认知的研究中，只有少数几个是专门关注的 中国移民。到目前为止，关于移民和认知之间联系的现有研究结果喜忧参半。一些人 研究报告说，移民的认知功能比美国出生的人差，而其他研究发现他们的认知能力更好 功能或无差别。就衡量标准而言，移民措施仅限于在以下国家出生、年龄 移民和居留时间。很少有人注意到移民前的影响(例如， 移民原因和早期生活条件)和移民后经历(例如，文化适应) 认知变化。此外，认知功能在很大程度上是由全局认知来定义的。鲜为人知 关于移民对特定认知领域的变化的影响，包括记忆领域， 执行功能和语言(被称为AD/ADRD的早期认知标记)。之前的研究已经 已报道的解释移民和认知之间关系的因素包括：年龄， 性别、教育程度、抑郁、血管健康和遗传风险因素。到目前为止，纽约市是最高的 亚洲以外任何城市的中国人口。西奈山的阿尔茨海默病研究中心(ADRC)， 位于纽约市，在吸引和评估华裔美国老年人方面有着成功的记录， 现有200多名年长的中国移民，他们的特征完全符合 人口学变量、医学疾病、心理状况、功能状态和遗传风险 标准的痴呆症评估。这项研究的目的是将痴呆症评估扩展到包括 衡量移民前和移民后的经历。我们的目标是：(1)阐明两者之间的联系 移民与认知--移民历史的综合测量与认知再认识 评估；以及(2)确定潜在的调解人和主持人，通过利用 基线数据的完整性。100名性格较好的老年中国移民将从ADRC招募 在西奈山进行拟议的研究。这项研究将为更大规模的研究提供初步数据，以检查 中国老年移民中移民与认知之间的联系。了解机制 通过移民经历影响移民人口的认知结果将指导 制定有针对性的干预措施，以预防AD/ADRD。