Examining Sleep Health and Adherence Outcomes Among Older HIV-Positive Men

检查老年艾滋病毒阳性男性的睡眠健康和依从性结果

• 批准号: 10170571
• 负责人: Brett M Millar
• 金额: $ 15.83万
• 依托单位: HUNTER COLLEGE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10170571
• 关键词: AIDS/HIV problem; Address; Adherence; Affect; Affective; Aging; Alcohol or Other Drugs use; Alcohols; Anal Sex; Anti-Retroviral Agents; Behavior; Bisexual; Chronic Disease; Cognition; Cognitive; Comparative Study; Complex; Continuity of Patient Care; Data; Decision Making; Distress; Drug usage; Elderly; Emotions; Enrollment; Epidemic; Exercise; Feedback; Future; Gays; Gender; General Population; Glean; Goals; HIV; HIV Seropositivity; Health; Health behavior; Heterosexuals; Impairment; Individual; Influentials; Informal Social Control; Intervention; Link; Literature; Measures; Mental Health; Meta-Analysis; Nature; Outcome; Participant; Personal Satisfaction; Pharmaceutical Preparations; Phase; Population; Predictive Factor; Process; Public Health; Quality of life; Recommendation; Reporting; Research; Research Design; Risk; Risk Factors; Role; Sample Size; Sampling; Sampling Studies; Science; Self Efficacy; Self-control as a personality trait; Sex Behavior; Sex Orientation; Sexual Partners; Sleep; Sleep Deprivation; Sleep disturbances; Testing; Time; Viral; Woman; Work; actigraphy; age group; aged; base; behavioral outcome; comparative; condoms; design; diaries; experience; follow up assessment; improved; interdisciplinary approach; men; multidisciplinary; negative mood; novel; physical conditioning; positive mood; racial diversity; recruit; response; sexual minority; sexual risk behavior; sleep behavior; sleep health; sleep quality; transmission process

Project Summary Sleep deficiency, given its impairing effects on emotion, cognition, and decision-making, is likely a key risk factor contributing to non-adherence to antiretroviral (ART) medications in older HIV-positive gay and bisexual men (GBM). However, research on sleep deficiency’s effect on ART adherence and on self-efficacy regarding adherence is very limited, has been mostly cross-sectional in nature, and has not focused on older adults. We are submitting this application in response to PAR-17-320, with the aim of conducting novel, hypothesis-driven exploratory research into sleep deficiency among older HIV-positive GBM within a daily diary study design. We propose to recruit and enroll a racially-diverse sample of 100 HIV-positive GBM, aged 50 or older, who report suboptimal adherence at baseline. Gathering 21 days of twice-daily diary data and wristwatch actigraphy data for objective sleep indicators, we will work to achieve three primary aims: SPECIFIC AIM 1: To test the direct effect of day-level sleep quality ART adherence on a given day. SPECIFIC AIM 2: To examine whether a potential mechanism by which day-level sleep quality affects ART adherence is through its direct effect on day-level self-efficacy for adherence. SPECIFIC AIM 3: To gather qualitative feedback from participants about sleep, ART adherence, barriers to improving both, and recommendations for how sleep health interventions could be tailored to this population. By exploring the role of sleep deficiency in ART adherence among older GBM, as well as gleaning qualitative feedback from participants in the follow-up assessment regarding sleep health, perceived barriers, and intervention possibilities, the proposed project has high potential to improve adherence interventions aimed at achieving viral suppression and improved wellbeing among this population, with potential future applications to other groups.

项目摘要 考虑到睡眠不足对情绪、认知和决策的损害作用，睡眠不足可能是一个关键风险 导致老年艾滋病毒阳性同性恋和双性恋者不依从抗逆转录病毒（ART）药物治疗的因素 男性（GBM）。然而，关于睡眠不足对ART依从性和自我效能的影响的研究表明， 坚持的情况非常有限，而且大多是跨部门性质的，并没有把重点放在老年人身上。 我们提交此申请是为了响应PAR-17-320，目的是进行新颖的， 在每日日记中对老年HIV阳性GBM睡眠不足的假设驱动的探索性研究 研究设计.我们建议招募100名年龄在50岁或50岁以下的HIV阳性GBM， 年龄较大，报告基线时依从性不佳。收集21天每天两次的日记数据和手表 为了获得客观的睡眠指标，我们将努力实现三个主要目标： 具体目标1：测试在给定的一天，白天睡眠质量ART依从性的直接影响。 具体目标2：研究日间睡眠质量是否影响ART的潜在机制 坚持是通过其对坚持的日常自我效能的直接影响。 具体目标3：从参与者那里收集关于睡眠、ART依从性、 改善两者，并建议如何睡眠健康干预措施可以适合这一人群。 通过探索睡眠不足在老年GBM中ART依从性中的作用，以及收集 来自参与者在后续评估中关于睡眠健康，感知障碍， 和干预的可能性，拟议的项目有很大的潜力，以改善遵守干预措施 旨在实现病毒抑制和改善这一人群的福祉，具有潜在的未来 应用到其他群体。