Examining Sleep Health and Adherence Outcomes Among Older HIV-Positive Men

检查老年艾滋病毒阳性男性的睡眠健康和依从性结果

• 批准号: 10170571
• 负责人: Brett M Millar
• 金额: $ 15.83万
• 依托单位: HUNTER COLLEGE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10170571
• 关键词: AIDS/HIV problem; Address; Adherence; Affect; Affective; Aging; Alcohol or Other Drugs use; Alcohols; Anal Sex; Anti-Retroviral Agents; Behavior; Bisexual; Chronic Disease; Cognition; Cognitive; Comparative Study; Complex; Continuity of Patient Care; Data; Decision Making; Distress; Drug usage; Elderly; Emotions; Enrollment; Epidemic; Exercise; Feedback; Future; Gays; Gender; General Population; Glean; Goals; HIV; HIV Seropositivity; Health; Health behavior; Heterosexuals; Impairment; Individual; Influentials; Informal Social Control; Intervention; Link; Literature; Measures; Mental Health; Meta-Analysis; Nature; Outcome; Participant; Personal Satisfaction; Pharmaceutical Preparations; Phase; Population; Predictive Factor; Process; Public Health; Quality of life; Recommendation; Reporting; Research; Research Design; Risk; Risk Factors; Role; Sample Size; Sampling; Sampling Studies; Science; Self Efficacy; Self-control as a personality trait; Sex Behavior; Sex Orientation; Sexual Partners; Sleep; Sleep Deprivation; Sleep disturbances; Testing; Time; Viral; Woman; Work; actigraphy; age group; aged; base; behavioral outcome; comparative; condoms; design; diaries; experience; follow up assessment; improved; interdisciplinary approach; men; multidisciplinary; negative mood; novel; physical conditioning; positive mood; racial diversity; recruit; response; sexual minority; sexual risk behavior; sleep behavior; sleep health; sleep quality; transmission process

Project Summary Sleep deficiency, given its impairing effects on emotion, cognition, and decision-making, is likely a key risk factor contributing to non-adherence to antiretroviral (ART) medications in older HIV-positive gay and bisexual men (GBM). However, research on sleep deficiency’s effect on ART adherence and on self-efficacy regarding adherence is very limited, has been mostly cross-sectional in nature, and has not focused on older adults. We are submitting this application in response to PAR-17-320, with the aim of conducting novel, hypothesis-driven exploratory research into sleep deficiency among older HIV-positive GBM within a daily diary study design. We propose to recruit and enroll a racially-diverse sample of 100 HIV-positive GBM, aged 50 or older, who report suboptimal adherence at baseline. Gathering 21 days of twice-daily diary data and wristwatch actigraphy data for objective sleep indicators, we will work to achieve three primary aims: SPECIFIC AIM 1: To test the direct effect of day-level sleep quality ART adherence on a given day. SPECIFIC AIM 2: To examine whether a potential mechanism by which day-level sleep quality affects ART adherence is through its direct effect on day-level self-efficacy for adherence. SPECIFIC AIM 3: To gather qualitative feedback from participants about sleep, ART adherence, barriers to improving both, and recommendations for how sleep health interventions could be tailored to this population. By exploring the role of sleep deficiency in ART adherence among older GBM, as well as gleaning qualitative feedback from participants in the follow-up assessment regarding sleep health, perceived barriers, and intervention possibilities, the proposed project has high potential to improve adherence interventions aimed at achieving viral suppression and improved wellbeing among this population, with potential future applications to other groups.

项目摘要 鉴于其对情绪，认知和决策的影响损害的影响，睡眠不足可能是关键风险 在较老的HIV阳性同性恋和双性恋中导致不遵守抗逆转录病毒（ART）药物的因素 男人（GBM）。但是，对睡眠不足对艺术依从性的影响以及对自我影响的研究 依从性非常有限，本质上是横截面的，并且没有集中于老年人。 我们正在按照17-320杆的响应提交此申请，目的是进行小说， 假设驱动的探索性研究每天日记中老年HIV阳性GBM睡眠不足的探索性研究 研究设计。我们建议招募和注册大约100个HIV阳性GBM的多样性样本，年龄在50岁或50岁或 年龄较大的人在基线报告次优的依从性。收集21天两次每日日记数据和手表 客观睡眠指标的行动图数据，我们将努力实现三个主要目的： 特定目的1：测试给定一天的日级睡眠质量艺术依从性的直接效果。 特定目标2：检查日间睡眠质量的潜在机制是否影响艺术 依从性是通过其直接影响遵守日级自我效能的。 特定目标3：收集参与者的定性反馈，涉及睡眠，艺术依从性，障碍 改善这两者，并建议如何为该人群量身定制睡眠健康干预措施。 通过探索睡眠不足在较旧的GBM中的艺术依从性中的作用以及收集 参与者的定性反馈有关睡眠健康，感知障碍的后续评估， 和干预的可能性，拟议的项目具有改善依从性干预措施的高潜力 旨在在该人群中实现病毒抑制和改善的福祉，并具有潜在的未来 申请其他群体。