Improving Physical Functioning in Older Cancer Survivors Through Light-Intensity Physical Activity

老年癌症幸存者面临着年龄和治疗相关的合并症，包括身体功能障碍。 身体活动不足和久坐行为会加剧这种损害。迫切需要掌握 对来自不同背景的老年幸存者有效和可获得的身体活动干预措施， 对他们来说是可行的、相关的和有意义的。此K 07辅导职业的目标 发展奖是协助辛迪布莱尔博士，成为一个独立的调查员，专门从事 以家庭为基础的干预措施，以改善得不到充分服务的癌症幸存者的健康和福祉。 具体而言，布莱尔博士将发展在设计和传播家庭干预措施方面的专业知识， 在老年癌症幸存者中采用全天体力活动的方法。这种方法侧重于 增加全天的光强度活动，同时减少和破坏久坐不动的活动。她的短- 长期目标包括以下方面的专门培训：1）与服务不足的癌症幸存者群体--老年人，农村， 2）现有和新兴的远程评估身体表现的技术;以及 3)设计、实施和评价家庭行为随机对照试验（RCT）。到 实现她的目标，提高她的专业知识，布莱尔博士将获得重点指导，从建立 研究人员和参加正式的课程和讲习班，指导学习经验，研讨会， 国家会议。研究：研究计划包括验证研究和可行性RCT。第一、 我们将评估使用视频会议远程评估身体表现的准确性和可靠性。 第二，我们将研究一种新的以家庭为基础的干预措施的可行性和可接受性， 使用全天方法进行高强度活动并减少久坐活动。64名老年癌症幸存者 (50%西班牙裔; 50%农村）将被随机分配到16周的基于理论的干预或修改后的等待名单 控制该干预使用电子活动监视器，与智能手机应用程序配对，以促进 意识，并能够自我监测活动和不活动。动机咨询将用于 为实现目标制定个性化战略。将在基线、干预后和6个月时收集数据 干预后。主要结局包括招募、保留、依从性和身体功能; 次要结果包括身体表现、身体活动的客观测量和久坐 行为和自我报告的生活质量。这项试验的结果将为最终的R 01资助的 RCT旨在检测具有临床意义和统计学显著性的效应。完成拟议的培训， 研究计划将准备布莱尔博士成功地竞争NIH R 01资金，并建立一个独立的 在老年癌症患者中使用全天方法促进（光强度）体力活动的研究计划 幸存者

Older cancer survivors are faced with age- and treatment-related comorbidities, including physical functional impairment, which are exacerbated by physical inactivity and sedentary behavior. There is a critical need for physical activity interventions that are effective and accessible to older survivors from diverse backgrounds that are designed to be feasible, relevant, and meaningful for them. The goal of this K07 Mentored Career Development Award is to assist Cindy Blair, PhD, with becoming an independent investigator, specializing in home-based interventions to improve the health and well-being of underserved cancer survivor populations. Specifically, Dr. Blair will develop expertise in the design and dissemination of home-based interventions that utilize a whole-of-day approach to physical activity in older cancer survivors. This approach focuses on increasing light-intensity activity throughout the day, while reducing and disrupting sedentary activity. Her short- term goals include specialized training in 1) working with underserved cancer survivor populations – older, rural, and ethnic minority; 2) existing and emerging technology for remote assessment of physical performance; and 3) design, implementation, and evaluation of home-based behavioral randomized controlled trials (RCT). To achieve her goals and enhance her expertise, Dr. Blair will receive focused mentorship from established investigators and participate in formal coursework and workshops, directed learning experiences, seminars, and national conferences. RESEARCH: The research plan includes a validation study and a feasibility RCT. First, we will evaluate the accuracy and reliability of using videoconferencing to remotely assess physical performance. Second, we will examine the feasibility and acceptability of a novel home-based intervention to promote light- intensity activity and reduce sedentary activity using a whole-of-day approach. Sixty-four older cancer survivors (50% Hispanic; 50% rural) will be randomized to either a 16-week theory-based intervention or a modified waitlist control. The intervention uses an electronic activity monitor that pairs with a smartphone app to promote awareness and enable self-monitoring of both activity and inactivity. Motivational counseling will be used to individually tailor strategies to achieve goals. Data will be collected at baseline, post-intervention, and 6-months post-intervention. The primary outcomes include recruitment, retention, adherence and physical function; secondary outcomes include physical performance, objective measures of physical activity and sedentary behavior, and self-reported quality of life. The results of this trial will inform the design of a definitive R01-funded RCT to detect clinically meaningful and statistically significant effects. Completion of the proposed training and research plan will prepare Dr. Blair to successfully compete for NIH R01 funding and establish an independent research program to promote (light-intensity) physical activity using a whole-of-day approach in older cancer survivors.