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Improving Physical Functioning in Older Cancer Survivors Through Light-Intensity Physical Activity

通过低强度的身体活动改善老年癌症幸存者的身体机能

基本信息

批准号：
10170287
负责人：
Cindy Kay Blair
金额：
$ 15.44万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-06-08 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10170287
关键词：
Accelerometer Adherence Adopted Adoption Adverse event Age Age-Years Attenuated Awareness Behavioral Cancer Survivor Cardiovascular Diseases Chronic Clinic Clinical Counseling Data Diabetes Mellitus Dissemination and Implementation Doctor of Philosophy Educational workshop Elderly Emerging Technologies Evaluation Exercise Funding Future Goals Guidelines Health Health Benefit Hispanics Home Impairment Individual Intervention K-Series Research Career Programs Learning Life Style Maintenance Malignant Neoplasms Measures Mentors Mentorship Methods Monitor Morbidity - disease rate Motivation Older Population Osteoporosis Outcome Participant Patient Self-Report Personal Satisfaction Phase Physical Function Physical Performance Physical activity Physical assessment Pilot Projects Policies Population Process Quality of life Randomized Randomized Controlled Trials Recording of previous events Research Research Personnel Resources Risk Rural Rural Minority Sampling Self Administration Surveys Survivors Target Populations Training United States National Institutes of Health Videoconferencing Vulnerable Populations Waiting Lists acceptability and feasibility adherence rate adverse event monitoring arm base comorbidity design effective intervention ethnic minority population exercise intervention experience functional decline functional disability improved light intensity moderate-to-vigorous physical activity novel performance tests physical inactivity post intervention primary endpoint primary outcome programs psychosocial recruit rural area satisfaction secondary endpoint secondary outcome sedentary sedentary activity sedentary lifestyle smartphone Application symposium theories trial design validation studies

项目摘要

Older cancer survivors are faced with age- and treatment-related comorbidities, including physical functional impairment, which are exacerbated by physical inactivity and sedentary behavior. There is a critical need for physical activity interventions that are effective and accessible to older survivors from diverse backgrounds that are designed to be feasible, relevant, and meaningful for them. The goal of this K07 Mentored Career Development Award is to assist Cindy Blair, PhD, with becoming an independent investigator, specializing in home-based interventions to improve the health and well-being of underserved cancer survivor populations. Specifically, Dr. Blair will develop expertise in the design and dissemination of home-based interventions that utilize a whole-of-day approach to physical activity in older cancer survivors. This approach focuses on increasing light-intensity activity throughout the day, while reducing and disrupting sedentary activity. Her short- term goals include specialized training in 1) working with underserved cancer survivor populations – older, rural, and ethnic minority; 2) existing and emerging technology for remote assessment of physical performance; and 3) design, implementation, and evaluation of home-based behavioral randomized controlled trials (RCT). To achieve her goals and enhance her expertise, Dr. Blair will receive focused mentorship from established investigators and participate in formal coursework and workshops, directed learning experiences, seminars, and national conferences. RESEARCH: The research plan includes a validation study and a feasibility RCT. First, we will evaluate the accuracy and reliability of using videoconferencing to remotely assess physical performance. Second, we will examine the feasibility and acceptability of a novel home-based intervention to promote light- intensity activity and reduce sedentary activity using a whole-of-day approach. Sixty-four older cancer survivors (50% Hispanic; 50% rural) will be randomized to either a 16-week theory-based intervention or a modified waitlist control. The intervention uses an electronic activity monitor that pairs with a smartphone app to promote awareness and enable self-monitoring of both activity and inactivity. Motivational counseling will be used to individually tailor strategies to achieve goals. Data will be collected at baseline, post-intervention, and 6-months post-intervention. The primary outcomes include recruitment, retention, adherence and physical function; secondary outcomes include physical performance, objective measures of physical activity and sedentary behavior, and self-reported quality of life. The results of this trial will inform the design of a definitive R01-funded RCT to detect clinically meaningful and statistically significant effects. Completion of the proposed training and research plan will prepare Dr. Blair to successfully compete for NIH R01 funding and establish an independent research program to promote (light-intensity) physical activity using a whole-of-day approach in older cancer survivors.

老年癌症幸存者面临着与年龄和治疗相关的合并症，包括身体功能