Improving Physical Functioning in Older Cancer Survivors Through Light-Intensity Physical Activity

老年癌症幸存者面临与年龄和治疗相关的并发症，包括身体功能 身体不活动和久坐行为会加剧损伤。迫切需要 对来自不同背景的老年幸存者有效和可获得的体力活动干预措施 对他们来说是可行的、相关的和有意义的。这个K07指导生涯的目标是 发展奖是帮助辛迪·布莱尔博士成为一名独立调查员，专门从事 以家庭为基础的干预措施，以改善未得到充分服务的癌症幸存者群体的健康和福祉。 具体地说，布莱尔博士将发展以家庭为基础的干预措施的设计和传播方面的专业知识， 对老年癌症幸存者采用全天体力活动的方法。此方法侧重于 增加全天的光强度活动，同时减少和破坏久坐不动的活动。她的短裤- 学期目标包括1)与服务不足的癌症幸存者群体合作的专门培训-老年、农村、 和少数民族；2)现有和新兴的体能远程评估技术；以及 3)基于家庭的行为随机对照试验(RCT)的设计、实施和评价。至 实现她的目标并增强她的专业知识，布莱尔博士将得到来自STORDING的重点指导 调查人员，并参加正式的课程和研讨会，指导学习经验，研讨会，以及 全国会议。研究：研究计划包括一项验证研究和一项可行性随机对照试验。第一, 我们将评估使用视频会议远程评估体能表现的准确性和可靠性。 第二，我们将研究一种新的以家庭为基础的干预措施的可行性和可接受性，以促进 全天强化运动，减少久坐不动。64名老年癌症幸存者 (50%西班牙裔；50%农村人)将随机接受为期16周的基于理论的干预或修改后的等待名单 控制力。这项干预活动使用了一个电子活动监测器，与智能手机应用程序配对以促进 了解并启用对活动和不活动的自我监控。激励咨询将被用来 个人量身定做战略以实现目标。数据将在基线、干预后和6个月内收集 干预后。主要结果包括招募、保留、坚持和身体机能； 次要结果包括体能、体力活动的客观测量和久坐不动 行为和自我报告的生活质量。该试验的结果将为最终的R01资助的设计提供参考 随机对照试验检测有临床意义和统计学意义的影响。完成拟议的培训和 研究计划将为布莱尔博士成功竞争NIH R01资金并建立一个独立的 在老年癌症患者中使用全天方法促进(光强度)体力活动的研究计划 幸存者。

Older cancer survivors are faced with age- and treatment-related comorbidities, including physical functional impairment, which are exacerbated by physical inactivity and sedentary behavior. There is a critical need for physical activity interventions that are effective and accessible to older survivors from diverse backgrounds that are designed to be feasible, relevant, and meaningful for them. The goal of this K07 Mentored Career Development Award is to assist Cindy Blair, PhD, with becoming an independent investigator, specializing in home-based interventions to improve the health and well-being of underserved cancer survivor populations. Specifically, Dr. Blair will develop expertise in the design and dissemination of home-based interventions that utilize a whole-of-day approach to physical activity in older cancer survivors. This approach focuses on increasing light-intensity activity throughout the day, while reducing and disrupting sedentary activity. Her short- term goals include specialized training in 1) working with underserved cancer survivor populations – older, rural, and ethnic minority; 2) existing and emerging technology for remote assessment of physical performance; and 3) design, implementation, and evaluation of home-based behavioral randomized controlled trials (RCT). To achieve her goals and enhance her expertise, Dr. Blair will receive focused mentorship from established investigators and participate in formal coursework and workshops, directed learning experiences, seminars, and national conferences. RESEARCH: The research plan includes a validation study and a feasibility RCT. First, we will evaluate the accuracy and reliability of using videoconferencing to remotely assess physical performance. Second, we will examine the feasibility and acceptability of a novel home-based intervention to promote light- intensity activity and reduce sedentary activity using a whole-of-day approach. Sixty-four older cancer survivors (50% Hispanic; 50% rural) will be randomized to either a 16-week theory-based intervention or a modified waitlist control. The intervention uses an electronic activity monitor that pairs with a smartphone app to promote awareness and enable self-monitoring of both activity and inactivity. Motivational counseling will be used to individually tailor strategies to achieve goals. Data will be collected at baseline, post-intervention, and 6-months post-intervention. The primary outcomes include recruitment, retention, adherence and physical function; secondary outcomes include physical performance, objective measures of physical activity and sedentary behavior, and self-reported quality of life. The results of this trial will inform the design of a definitive R01-funded RCT to detect clinically meaningful and statistically significant effects. Completion of the proposed training and research plan will prepare Dr. Blair to successfully compete for NIH R01 funding and establish an independent research program to promote (light-intensity) physical activity using a whole-of-day approach in older cancer survivors.