Lead Optimization and Mechanisms of Action of Dual-Acting Antitrypanosomal Agents
双效抗锥虫药物的先导化合物优化及作用机制
基本信息
- 批准号:10172488
- 负责人:
- 金额:$ 35.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-09 至 2025-06-30
- 项目状态:未结题
- 来源:
- 关键词:AffectAfricaAfrican TrypanosomiasisBenznidazoleBindingBiological AvailabilityCaringCathepsin LCathepsinsCathepsins BCentral AmericaChagas DiseaseChemicalsClinicalCommunicable DiseasesCommunitiesComputersContractsCountryDeveloping CountriesDiagnosticDiseaseDrug resistanceEconomic DevelopmentEconomically Deprived PopulationEconomicsEtiologyEvaluationFundingFutureGenerationsGoalsHealth care facilityHealthcareHumanIn VitroIndividualKnowledgeLaboratoriesLeishmaniaLife ExpectancyMedicalMetabolicModelingMolecular TargetMusNitroreductasesNorth AmericaParasitesParasitic DiseasesPathogenicityPharmaceutical ChemistryPharmaceutical PreparationsPlasmodiumPreclinical Drug DevelopmentProductivityPropertyProtozoaPublic HealthResearchResearch Project GrantsRiskSecureSeriesSideSolubilitySouth AmericaSoutheastern AsiaSouthern EuropeStructureStructure-Activity RelationshipStudentsSupervisionTropical DiseaseTrypanocidal AgentsTrypanosomaTrypanosoma brucei gambienseTrypanosoma cruziUnited StatesUnited States National Institutes of HealthWorld Health OrganizationX-Ray Crystallographyacute infectionanalogaqueousbasebiophysical techniqueschemotherapyclimate changecytotoxicdrug developmenteffective therapyefficacy studyexperiencefexinidazoleimprovedin vivoin vivo evaluationinhibitor/antagonistinnovationlead optimizationlow income countrymigrationmolecular modelingneglectnovelpathogenpreclinical studyquinolinetooltool developmentvector
项目摘要
Project Summary
Pathogenic protozoans cause several neglected, persistent, and emerging tropical diseases. These
diseases impact hundreds of millions of people worldwide, and they pose significant threat to
global public health, including that of the United States. The key problems of tropical diseases
are limited access to effective drugs, inadequate diagnostic tools, and development of drug
resistance to existing drugs by the etiological agents. Hence, continued effort to control, eliminate,
and provide safe and effective treatment options is crucial. In this SC1 project, our efforts will be
devoted to investigating new chemical entities that can serve as drug leads for human African
trypanosomiasis (HAT) and Chagas disease. The main objective is to investigate chemical entities
that can suppress the development of drug resistance by protozoan parasites to clinically used
nitroaromatic drugs. We envision that the studies outlined in this project will propel preclinical
studies of new generation antitrypanosomal agents that possess multiple mechanisms of action.
In addition, we expect that successful implementation of the aims and objectives of this project
will produce innovative and fundamental knowledge on antitrypanosomal agents.
项目摘要
致病原生动物导致几种被忽视的、持久的和新出现的热带疾病。这些
疾病影响着全世界数以亿计的人,它们对
全球公共卫生,包括美国的公共卫生。热带病的关键问题
获得有效药物的机会有限、诊断工具不足以及药物开发
病原菌对现有药物的耐药性。因此,继续努力控制、消除、
并提供安全有效的治疗选择至关重要。在这个SC1项目中,我们将努力
致力于研究可作为人类非洲药物线索的新化学物质
锥虫病(HAT)和恰加斯病。主要目的是调查化学物质。
可抑制原虫对临床用寄生虫的耐药性发展
硝基芳香族药物。我们预计,该项目中概述的研究将推动临床前
具有多种作用机制的新一代抗锥虫药物的研究。
此外,我们期待这一项目目的和目的的成功实施
将产生关于抗锥虫药物的创新和基础知识。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ifedayo Victor Ogungbe其他文献
Ifedayo Victor Ogungbe的其他文献
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{{ truncateString('Ifedayo Victor Ogungbe', 18)}}的其他基金
Hit to Lead Optimization of Non-Peptidic Inhibitors of Alphaviral Cysteine Protease
甲病毒半胱氨酸蛋白酶非肽抑制剂的优化
- 批准号:
10196140 - 财政年份:2021
- 资助金额:
$ 35.75万 - 项目类别:
Lead Optimization and Mechanisms of Action of Dual-Acting Antitrypanosomal Agents
双效抗锥虫药物的先导化合物优化及作用机制
- 批准号:
10445231 - 财政年份:2021
- 资助金额:
$ 35.75万 - 项目类别:
Lead Optimization and Mechanisms of Action of Dual-Acting Antitrypanosomal Agents
双效抗锥虫药物的先导化合物优化及作用机制
- 批准号:
10655612 - 财政年份:2021
- 资助金额:
$ 35.75万 - 项目类别:
Identification, Optimization and Structural Investigation of Antiprotozoal Agents and Molecular Target
抗原虫剂和分子靶标的鉴定、优化和结构研究
- 批准号:
9767240 - 财政年份:2017
- 资助金额:
$ 35.75万 - 项目类别:
Identification, Optimization and Structural Investigation of Antiprotozoal Agents and Molecular Target
抗原虫剂和分子靶标的鉴定、优化和结构研究
- 批准号:
9278882 - 财政年份:2017
- 资助金额:
$ 35.75万 - 项目类别:
Identification, Optimization and Structural Investigation of Antiprotozoal Agents and Molecular Target
抗原虫剂和分子靶标的鉴定、优化和结构研究
- 批准号:
10001069 - 财政年份:2017
- 资助金额:
$ 35.75万 - 项目类别:
Solution Structure and Novel Inhibitors of T. brucei Cathepsin L
布氏锥虫组织蛋白酶 L 的溶液结构和新型抑制剂
- 批准号:
8664726 - 财政年份:2014
- 资助金额:
$ 35.75万 - 项目类别:
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