Administration and Data Integration Core

管理和数据集成核心

基本信息

批准号：
10172232
负责人：
Hui Zheng
金额：
$ 24.08万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-06-01 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10172232
关键词：
Aging Agreement Alzheimer&apos s Disease Atlases Award Bioinformatics Biology Brain Businesses ChIP-seq Collaborations Communication Communities Conflict (Psychology)Consult Consultations Data Data Analyses Data Set Ensure Evaluation Funding Human Resources Individual Infrastructure Leadership Licensing Lysosomes Medicine Molecular and Cellular Biology Multiomic Data Notification Occupational activity of managing finances Online Systems Output Process Program Research Project Grants Proteome Proteomics Reagent Regulation Reporting Research Research Personnel Resources Sampling Scientist Signal Transduction Site Tauopathies Time United States National Institutes of Health Universities Videoconferencing Visualization Washington Work college conflict resolution data integration data resource data sharing lectures medical schools meetings member metabolome metabolomics mid-career faculty multiple omics programs recruit success synergism transcriptome sequencing

项目摘要

The objectives of the Administration and Data Integration Core (Core A) are three-fold: first, the Core will provide administrative support and financial management of the Program Project Grant (PPG); second, the Core will support cross-platform bioinformatics integration and sharing of multi-omic datasets generated by the Cores and Projects; third, the Core will facilitate interactions between the Cores and Projects, as well as between Baylor College of Medicine (BCM) and Washington University School of Medicine (WU), and will also provide overall scientific leadership of the PPG. The Core will be led by Dr. Hui Zheng, Director of the Huffington Center on Aging (HCOA) at BCM, and housed within the HCOA administrative unit. The Core will be co-led by Dr. Cristian Coarfa, Associate Professor of Molecular and Cellular Biology and an expert in integrative analysis and visualization of multi-omic data, who will oversee the bioinformatics and data sharing aspects of the PPG. To ensure effective management and successful execution of the objectives, a Scientific Advisory Board (SAB) will be formed upon notification of award that will be composed of three members with established leadership and scientific expertise in AD, tauopathy, aging, lysosomal biology, proteomics, and metabolomics. The Core will consult with the SAB for overall program management and scientific direction. The Core has also recruited individuals from BCM and WU who will offer support on institutional resources and advice on conflict resolution if needed. The specific aims of the Administration and Data Integration Core are as follows: 1) Provide overall scientific leadership; 2) Provide financial, administrative, and organizational support; 3) Perform multi-omics data analysis and integration and ensure rapid public access to the datasets; 4) Generate a web-based first-in-class Aging- and Tauopathy-associated Lysosomal atlas (ATLas) of the lysosomal proteome and metabolome. Overall, the core is ultimately responsible for the PPG’s success, and will work with NIH and SAB closely to ensure that the team as a whole achieves its milestones and deliverables.

管理和数据集成核心（核心A）的对象是三倍：首先，核心将提供计划项目赠款（PPG）的行政支持和财务管理；第二，核心将支持跨平台的生物信息学集成和共享由核心和项目；第三，核心将在核心和项目之间喜欢的互动以及在贝勒医学院（BCM）和华盛顿大学医学院（WU）之间，也将提供PPG的总体科学领导。核心将由Zheng博士领导赫芬顿老化中心（HCOA）位于BCM，并安置在HCOA行政部门内。核心意愿由分子和细胞生物学副教授Cristian Coarfa博士共同领导，专家多运动数据的综合分析和可视化，他们将监督生物信息学和数据共享 PPG的各个方面。为了确保有效的管理和成功执行目标，科学咨询委员会（SAB）将在通知颁奖后成立，该奖项由三名成员组成在AD，Tauopathy，衰老，溶酶体生物学，蛋白质组学和代谢组学。核心将咨询SAB，以获取整体计划管理和科学方向。核心还招募了来自BCM和WU的个人，他们将在机构资源和如果需要，有关冲突解决方案的建议。管理和数据集成核心的具体目的是如下：1）提供整体的科学领导； 2）提供财务，行政和组织支持; 3）执行多摩斯数据分析和集成，并确保公众对数据集的快速访问； 4）生成基于网络的一流的老化和陶氏病相关的溶酶体图集（地图集）溶酶体蛋白质组和代谢组。总体而言，核心最终对PPG的成功负责，并且将与NIH和SAB合作，以确保整个团队都实现了其里程碑，并且可交付成果。