Administration and Data Integration Core

行政和数据集成核心(核心A)的目标有三个：第一，核心将 提供方案项目赠款(PPG)的行政支持和财务管理； CORE将支持跨平台生物信息学集成和共享由 核心和项目；第三，核心将促进核心和项目之间的互动，以及 贝勒医学院(BCM)和华盛顿大学医学院(WU)之间的合作，还将 为PPG提供全面的科学领导。核心将由郑辉博士领导，该中心主任 位于BCM的赫芬顿老龄中心(HCOA)，位于HCOA行政单位内。核心意志 由Cristian Coarfa博士共同领导，他是分子和细胞生物学副教授和 多组数据的综合分析和可视化，谁将监督生物信息学和数据共享 关于PPG的一些方面。为确保目标的有效管理和成功执行，科学的 顾问委员会将在获奖通知后成立，由三名成员组成，成员包括 在AD、肌萎缩侧索硬化症、衰老、溶酶体生物学、蛋白质组学和 代谢组学。CORE将与SAB就整体计划管理和科学指导进行磋商。 核心还从BCM和Wu招聘了人员，他们将在机构资源和 如有需要，可就冲突解决提供建议。管理和数据集成核心的具体目标是 1)提供全面的科学领导；2)提供财务、行政和组织 支持；3)进行多组学数据分析和集成，并确保公众快速访问数据集； 4)生成一份基于网络的一流的与衰老和肌萎缩侧索硬化症相关的溶酶体图集(Atlas) 溶酶体蛋白质组和代谢组。总体而言，核心是PPG成功的最终责任，并且 将与NIH和SAB密切合作，以确保整个团队实现其里程碑并 可交付成果。

The objectives of the Administration and Data Integration Core (Core A) are three-fold: first, the Core will provide administrative support and financial management of the Program Project Grant (PPG); second, the Core will support cross-platform bioinformatics integration and sharing of multi-omic datasets generated by the Cores and Projects; third, the Core will facilitate interactions between the Cores and Projects, as well as between Baylor College of Medicine (BCM) and Washington University School of Medicine (WU), and will also provide overall scientific leadership of the PPG. The Core will be led by Dr. Hui Zheng, Director of the Huffington Center on Aging (HCOA) at BCM, and housed within the HCOA administrative unit. The Core will be co-led by Dr. Cristian Coarfa, Associate Professor of Molecular and Cellular Biology and an expert in integrative analysis and visualization of multi-omic data, who will oversee the bioinformatics and data sharing aspects of the PPG. To ensure effective management and successful execution of the objectives, a Scientific Advisory Board (SAB) will be formed upon notification of award that will be composed of three members with established leadership and scientific expertise in AD, tauopathy, aging, lysosomal biology, proteomics, and metabolomics. The Core will consult with the SAB for overall program management and scientific direction. The Core has also recruited individuals from BCM and WU who will offer support on institutional resources and advice on conflict resolution if needed. The specific aims of the Administration and Data Integration Core are as follows: 1) Provide overall scientific leadership; 2) Provide financial, administrative, and organizational support; 3) Perform multi-omics data analysis and integration and ensure rapid public access to the datasets; 4) Generate a web-based first-in-class Aging- and Tauopathy-associated Lysosomal atlas (ATLas) of the lysosomal proteome and metabolome. Overall, the core is ultimately responsible for the PPG’s success, and will work with NIH and SAB closely to ensure that the team as a whole achieves its milestones and deliverables.