Administration and Data Integration Core

管理和数据集成核心（核心A）的目标有三个方面：首先，核心将 提供行政支持和计划项目补助金（PPG）的财务管理;第二， 核心将支持跨平台的生物信息学集成和共享由 核心和项目;第三，核心将促进核心和项目之间的互动， 贝勒医学院（Baylor College of Medicine）和华盛顿大学医学院（Washington University School of Medicine）之间，还将 为PPG提供全面的科学领导。核心小组将由中国科学院环境与发展研究所所长郑惠博士领导。 赫芬顿老龄化中心（HCOA）在华盛顿，并设在HCOA行政单位。芯会 由分子和细胞生物学副教授， 多组学数据的综合分析和可视化，谁将监督生物信息学和数据共享 PPG的各个方面。为确保有效管理和成功执行目标， 咨询委员会（SAB）将成立后，通知授予，将由三名成员组成， 在AD、tau蛋白病、衰老、溶酶体生物学、蛋白质组学和 代谢组学核心将与SAB协商整体计划管理和科学指导。 核心小组还从联合国难民事务高级专员办事处和世界大学招募了人员，他们将提供机构资源方面的支助， 如有必要，提供解决冲突的建议。管理和数据集成核心的具体目标是 1）提供全面的科学领导; 2）提供财务，行政和组织 3）进行多组学数据分析和整合，并确保公众快速访问数据集; 4)生成一个基于网络的一流的老化和Tauopathy-associated溶酶体图谱（ATLas）， 溶酶体蛋白质组和代谢组。总的来说，核心是最终负责PPG的成功， 我将与NIH和SAB密切合作，以确保整个团队实现其里程碑， 可交付成果。

The objectives of the Administration and Data Integration Core (Core A) are three-fold: first, the Core will provide administrative support and financial management of the Program Project Grant (PPG); second, the Core will support cross-platform bioinformatics integration and sharing of multi-omic datasets generated by the Cores and Projects; third, the Core will facilitate interactions between the Cores and Projects, as well as between Baylor College of Medicine (BCM) and Washington University School of Medicine (WU), and will also provide overall scientific leadership of the PPG. The Core will be led by Dr. Hui Zheng, Director of the Huffington Center on Aging (HCOA) at BCM, and housed within the HCOA administrative unit. The Core will be co-led by Dr. Cristian Coarfa, Associate Professor of Molecular and Cellular Biology and an expert in integrative analysis and visualization of multi-omic data, who will oversee the bioinformatics and data sharing aspects of the PPG. To ensure effective management and successful execution of the objectives, a Scientific Advisory Board (SAB) will be formed upon notification of award that will be composed of three members with established leadership and scientific expertise in AD, tauopathy, aging, lysosomal biology, proteomics, and metabolomics. The Core will consult with the SAB for overall program management and scientific direction. The Core has also recruited individuals from BCM and WU who will offer support on institutional resources and advice on conflict resolution if needed. The specific aims of the Administration and Data Integration Core are as follows: 1) Provide overall scientific leadership; 2) Provide financial, administrative, and organizational support; 3) Perform multi-omics data analysis and integration and ensure rapid public access to the datasets; 4) Generate a web-based first-in-class Aging- and Tauopathy-associated Lysosomal atlas (ATLas) of the lysosomal proteome and metabolome. Overall, the core is ultimately responsible for the PPG’s success, and will work with NIH and SAB closely to ensure that the team as a whole achieves its milestones and deliverables.