Lysosome Regulation and Signaling in Aging and Alzheimer's Disease

衰老和阿尔茨海默病中的溶酶体调节和信号传导

• 批准号: 10172231
• 负责人: Hui Zheng
• 金额: $ 263.3万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10172231
• 关键词: Adult; Age; Aging; Alzheimer' s Disease; Atlases; Autophagocytosis; Biological Process; Biological Response Modifier Therapy; Biology; Brain; Cell Nucleus; Cell physiology; Characteristics; Collaborations; Data; Degenerative Disorder; Etiology; Functional disorder; Genes; Genetic Transcription; Goals; Hippocampus (Brain); Histones; Homeostasis; Image; Impairment; Knock-in Mouse; Lysosomes; Measures; Metabolism; Modeling; Modification; Molecular; Mus; Nerve Degeneration; Neurodegenerative Disorders; Neurons; Nuclear Translocation; Online Systems; Organelles; Output; Pathway interactions; Pattern; Positioning Attribute; Post-Translational Modification Site; Post-Translational Protein Processing; Property; Proteome; Proteomics; Regulation; Regulatory Pathway; Research Support; Risk Factors; Signal Pathway; Signal Transduction; Signaling Molecule; Site; Specificity; Stress; Tauopathies; Technology; Testing; Time; Transcriptional Activation; Ursidae Family; biological adaptation to stress; brain health; combat; detection of nutrient; functional decline; genetic risk factor; hyperphosphorylated tau; in vivo; insight; interest; metabolome; metabolomics; preservation; programs; protein aggregation; tau Proteins; therapeutic target; tool; transcriptome; vacuolar H+-ATPase